Wei-Li Wu

Wei-Li Wu, Associate professor
		Education and Experience: B.S., National Sun Yat-sen University, 1997-2001 M.S., National Sun Yat-sen University, 2001-2003 Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center (co-sponsored by Academia Sinica, National Defense Medical Center, and National Health Research Institutes), 2005-2011 Postdoctoral Scholar, Academia Sinica, 2011-2012 Postdoctoral Scholar, California Institute of Technology, 2012-2018 Visiting Associate, California Institute of Technology, 2018-2021 Assistant Professor, National Cheng Kung University, 2018-2023 Associate Professor, National Cheng Kung University, 2023-now
Specialty: Neuropsychiatric disorder; Gut-Brain axis; Neuroimmunology; Host and gut microbes interaction; Behavioral physiology
Award: 2012. Best Poster Presentation Award, National Institutes of Health (NIH) Silvio O. Conte Centers for Basic and Translational Mental Health Retreat, Denver, CO, USA 2011. Postdoctoral Scholar Fellowship. Postdoctoral Research Abroad Program sponsored by National Science Council, Taiwan
E-mail	wlwu@ncku.edu.tw
Office	82-0717 ext. 5458		Laboratory	82-0753 ext. 5435
Hobbies: Gourmet food; Traveling
Research interests：
1.Investigate the role of gut microbiota in autism spectrum disorders (ASD). 2.Examine the effect of gut microbial metabolites in stress response. 3.Understand the mechanism of gut-brain axis.
Lab website:https://sites.google.com/view/wlwu/home
People:
Current member PhD student: Tzu-Ting Lai, Yu-Hsuan Tsai MS student: Tzu-Hsuan Yao, Shin-Mei Wen, Ru-Qing Zheng Assistant： Former member PhD student: Chia-Wei Liou MS student: Jo-Ting Wu, Tzu-Ting Lai, Yuan-Yuan Lin, Yu-Hsuan Tsai, Jia-Ying Xue
Publication list（PubMed Link）
PUBLICATIONS * corresponding author Lai TT, Tsai YH, Liou CW, Fan CH, Hou YT, Yao TH, Chuang HL, Wu WL. The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling. NPJ Biofilms and Microbiomes. 2024 Jan 16;10(1):2. doi: 10.1038/s41522-024-00477-w. PMID: 38228675. SpringerNature Research Communities Blog Post/Behind the paper: New research unveiling the invisible puppeteers: how our gut microbiota pulls the strings on host locomotion. https://go.nature.com/3tYXa6j Lai TT, Liou CW, Tsai YH, Lin YY, Wu WL. Butterflies in the gut: the interplay between intestinal microbiota and stress. Journal of Biomedical Science. 2023 Nov 28;30(1):92. doi: 10.1186/s12929-023-00984-6. PMID: 38012609; PMCID: PMC10683179. Liou CW, Cheng SJ, Yao TH, Lai TT, Tsai YH, Chien CW, Kuo YL, Chou SH, Hsu CC, Wu WL. Microbial metabolites regulate social novelty via CaMKII neurons in the BNST. Brain Behavior and Immunity. 2023 Oct;113:104-123. doi: 10.1016/j.bbi.2023.06.029. Epub 2023 Jun 29. PMID: 37393058. Liou, C.W., Yao, Z.H., Wu, W.L., 2022. Intracerebroventricular delivery of gut-derived microbial metabolites in mice. Journal of Visualized Experiments : JoVE. Jun 2;(184). doi: 10.3791/63972. PMID: 35723471. Wu, J.T., Sun, C.L., Lai, T.T., Liou, C.W., Lin, Y.Y., Xue, J.Y., Wang, H.W., Chai, L.M.X., Lee, Y.J., Chen, S.L., Chang, A.Y.W., Hung, J.H., Hsu, C.C., Wu, W.L., 2022. Oral short-chain fatty acids administration regulates innate anxiety in adult microbiome-depleted mice. Neuropharmacology. Aug 15;214:109140. doi: 10.1016/j.neuropharm.2022.109140. Epub 2022 May 22. PMID: 35613660. Needham, B.D., Funabashi, M., Adame, M.D., Wang, Z., Boktor, J., Haney, J., Wu, W.L., Rabut, C., Ladinsky, M.S., Hwang, S.J., Guo, Y., Griffiths, J.A., Knight, R., Bjorkman, P.J., Shapiro, M.G., Geschwind, D.H., Holschneider, D.P., Fischbach, M.A., Mazmanian, S.K., 2022. A gut-derived metabolite alters brain activity and anxiety behavior in mice. Nature 602, 647–653 https://doi.org/10.1038/s41586-022-04396-8 Wu, W.L., Adame, M.D., Liou, C.W., Barlow, J.T., Lai, T.T., Sharon G., Schretter, C.E., Needham, B.D., Wang, M.I., Tang, W., Ousey, J., Lin, Y.Y., Yao, T.H., Abdel-Haq, R., Beadle, K., Gradinaru, V., Ismagilov, R.F., Mazmanian, S.K., 2021. Microbiota regulate social behavior via stress response neurons in the brain. Nature 595, 409-414 https://doi.org/10.1038/s41586-021-03669-y Wu, W.L., Cheng, S.J., Lin, S.H., Chuang, Y.C., Huang, E.Y., Chen, C.C., 2019. The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Frontiers in Cellular Neuroscience, 13:86. doi: 10.3389/fncel.2019.00086.eCollection 2019. Lee YK, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK., 2018. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere, 3, e00587-18. doi: 10.1128/mSphere.00587-18. Ko, J., Isas, J.M., Sabbaugh, A., Yoo, J.H., Pandey, N.K., Chongtham, A., Ladinsky, M., Wu, W.L., Rohweder, H., Weiss, A., Macdonald, D., Munoz-Sanjuan, I., Langen, R., Patterson, P.H., Khoshnan, A., 2018. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human molecular genetics, 27, 2330-2343. Needham, B.D., Tang, W., Wu, W.L., 2018. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Developmental Neurobiology, 78, 474-499. Wu, W.L., 2017. Association among gut microbes, intestinal physiology, and autism. EBioMedicine, 25. 11-12. Chan, K.Y., Jang, M.J., Yoo, B.B., Greenbaum, A., Ravi, N., Wu, W.L., Óscar Sánchez-Guardado, L., Lois, C., Mazmanian, S.K., Deverman, B.E., Gradinaru, V., 2017. Engineered adeno-associated viruses for efficient and noninvasive gene delivery throughout the central and peripheral nervous systems. Nature Neuroscience, 20, 1172-1179. Wu, W.L., Hsiao, E.Y., Yan, Z., Mazmanian, S.K., Patterson, P.H., 2017. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain, Behavior, and Immunity. 62, 11-23 (Highlighted in: Brain, Behavior, and Immunity. 62: 9-10.) Chu, H., Khosravi, A., Kusumawardhani, I.P., Kwon, A.H., Vasconcelos, A.C., Cunha, L.D., Mayer, A.E., Shen, Y., Wu, W.L., Kambal, A., Targan, S.R., Xavier, R.J., Ernst, P.B., Green, D.R., McGovern, D.P., Virgin, H.W., Mazmanian, S.K., 2016. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science, 352, 1116-1120. Chow, K.H., Yan, Z., Wu, W.L., 2016. Induction of maternal immune activation in mice at mid-gestation stage with viral mimic poly(I:C). Journal of Visualized Experiments : JoVE, e53643. Deverman, B.E., Pravdo, P.L., Simpson, B.P., Kumar, S.R., Chan, K.Y., Banerjee, A., Wu, W.L., Yang, B., Huber, N., Pasca, S.P., Gradinaru, V., 2016. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nature Biotechnology, 34, 204-209. Wu, W.L., Adams, C.E., Stevens, K.E., Chow, K.H., Freedman, R., Patterson, P.H., 2015. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain, Behavior, and Immunity, 46, 192-202. Wu, W.L., Cheng, C.F., Sun, W.H., Wong, C.W., Chen, C.C., 2012. Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacology & Therapeutics, 134, 127-138. Wu, W.L., Lin, Y.W., Min, M.Y., Chen, C.C., 2010. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes, Brain and Behavior, 9, 603-614. Wu, W.L., Wang, C.H., Huang, E.Y., Chen, C.C., 2009. Asic3(-/-) female mice with hearing deficit affects social development of pups. PLoS One, 4, e6508. Lin, Y.W., Min, M.Y., Lin, C.C., Chen, W.N., Wu, W.L., Yu, H.M., Chen, C.C., 2008. Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3. Neuroscience, 151, 544-557. Liu, R.T., Chen, Y.J., Chou, F.F., Li, C.L., Wu, W.L., Tsai, P.C., Huang, C.C., Cheng, J.T., 2005. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clinical Endocrinology, 63, 461-466. BOOK Malkova N., Wu, W.L. (Co-first author), Hsiao, E. Y., 2015. Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. Modeling the Psychopathological Dimensions of Schizophrenia, eds Pletnikov, M., Waddington, J. (Elsevier). CONFERENCE PAPERS Deverman, B.E. and Pravdo, P.L. and Simpson, B.P. and Kumar, S.R. and Luo, Y. and Chan, K.Y. and Banerjee, A. and Wu, W.L. and Yang, B. and Huber, N. and Pasca, S.P. and Gradinaru, V. (2016) Using Cre-Dependent In Vivo Selection to Identify AAV Variants That Enable Efficient and Widespread Gene Transfer to the Adult Central Nervous System. Molecular Therapy, 24 (S1). S99. ISSN 1525-0016. Wu, W.L. and Hsiao, E.Y. and Yan, Z. and Mazmanian, S.K. and Patterson, P.H. (2015) Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation. Schizophrenia Bulletin, 41 (S1). Art. No. S216. ISSN 0586-7614. Wu, W.L. and Adams, C. E. and Stevens, K.E. and Freedman, R. and Patterson, P.H. (2015) Nicotinic Cholinergic Modulation of the Fetal Brain Response to Maternal Immune Activation. Schizophrenia Bulletin, 41 (S1). S216. ISSN 0586-7614.
Laboratory View
Laboratory activities