顏賢章（Shian-Jang Yan）副教授

學經歷：

台灣大學 動物系/生命科學系 學士，1995

美國羅徹斯特大學（University of Rochester）博士，2005

成大生理所 助理教授2012-2020，

成大生理所 副教授2020-迄今

專長學科 ：

分子老年學、表觀遺傳學、奈米毒理學

獎勵事項 ：

2009-2012 Ruth L. Kirschstein National Research Service Award, NIH, USA

2012-2015 Ministry of Science and Technology (MOST, Taiwan) Highly Recruited Outstanding Scientist Award科技部/國科會延攬特殊優秀人才

2016 NCKU Excellent Teaching Award國立成功大學教學優良教師

2018 Ministry of Science and Technology (MOST) Mentor Award for Outstanding Undergraduate Research 科技部指導大專學生研究計畫研究創作獎

2019 NCKU Dept. of Medicine Excellent Teaching Award國立成功大學醫學系教學優良教師

2020 NCKU Dept. of Medicine Excellent Mentor Award國立成功大學醫學系優良導師

E-mail

johnyan@mail.ncku.edu.tw

辦公室

82-0732 分機：5437

實驗室

82-0739 分機：5444

嗜好：戶外活動，超級馬拉松/越野跑，登山，自行車，旅遊，籃球

研究方向及興趣：

1.   為何不同類型功能的細胞使用相同的基因組涉及表觀遺傳過程（epigenetics process)。這些過程必須受到嚴格的監管，以防止不適當的細胞行為可能導致的人類疾病如癌症和過早老化。

2.   本實驗室利用遺傳、 生化、 分子和細胞生物、 藥理、 和高解析度即時成像技術，並結合果蠅和哺乳動物系統上有效的遺傳學工具，研究抗老及抗癌的機制。

3.   我們的工作側重於信號傳遞 (signaling transduction pathways) 和染色質因子 (chromatin factors） 之間的網路 (network)，研究表觀遺傳的信號傳遞和染色質因子網路與環境疾病之間的連接。隨著我們更加地瞭解表觀遺傳機制，希望可以提供新的方法及藥物以預防治療癌症和老年疾病。

4 利用「果蠅」研究奈米物質毒性以避免奈米物質毒性，目前研究重心特別放在奈米銀對活體生物的影響及其細胞與分子機制。奈米銀是在日常生活中被廣泛使用的材質，主要因為奈米銀有殺菌的效果，然而這樣的應用對活體生物的安全性及作用機制有待進一步探討。我們發現奈米銀在不同劑量的清況下，可籍由活性氧物種（ROS）的產生及其誘導的氧化壓力反應，破壞動物發育、縮減動物壽命及其抗氧化的耐受度。

實驗室成員：

現在成員

博士後：陳姿羽

博士班：吳博仁、張哲維、Ali Zain (展阿利)

碩士班：陳嘉緹 (碩二)、宋承翰 (碩二)、胡雅媛 (碩一)、曾靖雯 (碩一)

過去成員

博士班：陳姿羽 (2022)、毛彬旭 (2021)

碩士班：秦玉萱（2021)、蘇裕宸（2020)、譚永鈺（2020)、劉孟璇（2019)、賴冠榮（2018)、劉嘉瑋（2018)、張哲維（2017)、陳姿羽（2016)、吳博仁（2015)、陳玉庭（2015)、沈郁家（2015)、黃巧君（2015）

大學部：李登宏（醫學)、陳俞璇（護理)、李冠儀（醫學）

學生獎勵事項 ：

2022成功大學Grand Review學術競賽博士生傑出獎 (陳姿羽)

2021成功大學醫學院基醫所研究日甲等 (張哲維)

2021成功大學醫學院基醫所優秀論文 (張哲維)

2021成功大學醫學院研究日口頭報告佳作 (張哲維)

2021中國生理學會年會暨學術研討會壁報論文競賽第3名 (秦玉萱)

2019全國3分鐘生科論文口說競賽南區優勝 (陳姿羽)

2019第一屆毒理學會墾丁冬令營英文口頭論文競賽第一名 (陳姿羽)

2018 科技部大專學生研究計畫研究創作獎（李登宏）

2017&2018 科技部大專生暑期研究計劃（李登宏）

2017成功大學醫學院大生理所英文口頭進度報告第一名 (張哲維)

2016成功大學醫學院學生暑期研究優秀獎（李登宏）

2015科技部大專生暑期研究計劃（陳俞璇）

2015成功大學醫學院學生暑期研究佳作獎（李冠儀）

2014成功大學醫學院學生暑期研究第二名（陳俞璇）

相關著作（PubMed連結）

(5 year IFs and ranking by JIF (R/C) are based on the latest JCR 2021)

1.Po-Jen Wu, Shian-Jang Yan* (2022, Oct). HP1a-mediated heterochromatin formation promotes  antimicrobial responses against Pseudomonas aeruginosa infection. BMC Biology, 20(234):1-16. London, United Kingdom. 5 year IF=8.641. R/C=10/94, BIOLOGY.

2.Bin-Hsu Mao, Yi-Kai Luo, Bour-Jr Wang, Chun-Wan Chen, Fong-Yu Cheng, Yu-Hsuan Lee, Shian-Jang Yan*, Ying-Jan Wang* (2022, Jan). Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo. Particle and Fibre Toxicology, 19(6): 1-25. London, United Kingdom. 5 year IF=9.14. R/C=4/94, TOXICOLOGY.

3.Che-Wei Chang, Yu-Chia Shen, and Shian-Jang Yan* (2021, Dec). HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression. Cell Death & Disease, 12(1130), 1-12. London, United Kingdom. 5 year IF=9.62. R/C=36/195, CELL BIOLOGY.

4.Chia-Jung Yu^#, Dian W. Damaiyanti^#, Shian-Jang Yan, Chih-Hsing Wu, Ming-Jer Tang, Dar-Bin Shieh, Peter P. Liu and Ping-Yen Liu (2021, Dec). The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes. International Journal of Molecular Sciences, 22, 13281, 1-13. Basel, Switzerland. 5 year IF=6.628. R/C=69/297, BIOCHEMISTRY & MOLECULAR BIOLOGY.

5.Zi-Yu Chen, Yu-Chen Su, Fong-Yu Cheng, Shian-Jang Yan*, and Ying-Jan Wang* (2021, Dec). Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene. Environmental Science-Nano, 8, 3774-3791. London, United Kingdom. 5 year IF=9.35. R/C=29/279, ENVIRONMENTAL SCIENCES.

6.DJ Klionsky...Shian-Jang Yan...et al. (2021, Jan). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1):1-382. 5 year IF=16.142. R/C=22/195, CELL BIOLOGY.

7.Guan-Rong Lai, Yi-Fen Lee, Shian-Jang Yan*, Huei-Ju Ting* (2020, May). Active vitamin D induced gene-specific hypomethylation in prostate cancer cells developing vitamin D resistance. American Journal of Physiology-Cell Physiology, 318: C836-847. Bethesda, United States of America. 5 year IF=5.225, R/C=14/81, PHYSIOLOGY.

8.Zi-Yu Chen†, Nian-Jhen Li, Fong-Yu Cheng, Jian-Feng Hsueh, Chiao-Ching Huang, Fu-I Lu, Tzu-Fun Fu, Shian-Jang Yan†, Yu-Hsuan Lee*, and Ying-Jan Wang* (2020, Apr). The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos. International Journal of Molecular Sciences, 21(8), 2864: 1-20. Basel, Switzerland. 5 year IF=6.628. R/C=69/297, BIOCHEMISTRY & MOLECULAR BIOLOGY.

9.Rong-Jane Chen, Yu-Ying Chen, Mei-Yi Liao, Yu-Hsuan Lee, Zi-Yu Chen, Shian-Jang Yan, Ya-Ling Yeh, Li-Xing Yang, Yen-Ling Lee, Yuan-Hua Wu*, Ying-Jan Wang* (2020, Mar). The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies. International Journal of Molecular Sciences, 21(7), 2387: 1-24. Basel, Switzerland. 5 year IF=6.628. R/C=69/297, BIOCHEMISTRY & MOLECULAR BIOLOGY.

10.Bin-Hsu Mao, Zi-Yu Chen, Ying-Jang Wang* & Shian-Jang Yan* (2018, Feb). Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses. Scientific Reports, 8: 2445, 1-16. London, United Kingdom. 5 year IF=5.516. R/C=19/74, MULTIDISCIPLINARY SCIENCES.

11.Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, Hsin-Su Yu, Mami Noda, Chi-Yu Lu, Chu-Huang Chen, Shian-Jang Yan*, Tohru Yoshioka* (2017, Jun). Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. Scientific Reports, 7 (3606): 1-11. London, United Kingdom. 5 year IF=5.516. R/C=19/74, MULTIDISCIPLINARY SCIENCES.

12.Bin-Hsu Mao, Jui-Chen Tsai, Chun-Wan Chen, Shian-Jang Yan*, Ying-Jan Wang* (2016, Oct). Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy. Nanotoxicology, 10(8):1021-40. Milton Park, United Kingdom. 5 year IF=6.319. R/C=13/94, TOXICOLOGY.

13.Wen-Li Hsu, Jian-He Lu, Mami Noda, Ching-Ying Wu, Jia-dai Liu, Manabu Sakakibara, Ming-Hsien Tsai, Hsin-Su Yu, Ming-Wei Lin, Yaw-Bin Huang, Shian-Jang Yan*, Tohru Yoshioka* (2015, Nov). Derinat Protects Skin against Ultraviolet-B (UVB)-Induced Cellular Damage. Molecules, 20(11):20297-311. Basel, Switzerland. 5 year IF=5.11. R/C=65/179, CHEMISTRY, MULTIDISCIPLINARY.

14.Amy Tsurumi, Pranabanada Dutta, Shian-Jang Yan, Robin Sheng, Willis X. Li* (2013, Oct). Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Scientific Reports, 3:1-9. London, United Kingdom. 5 year IF=5.516. R/C=19/74, MULTIDISCIPLINARY SCIENCES.

15.Kriti Gaur, Jinghong Li, Dakun Wang, Pranabananda Dutta, Shian-Jang Yan, Amy Tsurumi, Hartmut Land, Guan Wu, Willis X. Li* (2013, Jan). The Birt-Hogg-Dube tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis. Human Molecular Genetics, 22(2), 284-299. Oxford, England. 5 year IF=5.999. R/C=36/175, GENETICS & HEREDITY.

16.Shian-Jang Yan^#, Yi-Fen Lee^#, Huei-Ju Ting^#, Ning-Chun Liu, Su Liu, Shin-Jen Lin, Shauh-Der Yeh, Gonghui Li, Chawnshang Chang* (2012, Jun). Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. CELLULAR & MOLECULAR BIOLOGY LETTERS, 17(2), 309-22. London, United Kingdom. 5 year IF=7.36, R/C=41/297, BIOCHEMISTRY & MOLECULAR BIOLOGY.

17.Huei-Ju Ting, Sayeda Yasmin-Karim, Shian-Jang Yan, Jong-Wei Hsu, Tzu-Hua Lin, Weisi Zeng, James Messing, Tzong-Jeng Sheu, Bo-Ying Bao, Willis X. Li, Edward Messing, Yi-Fen Lee* (2012, Feb). A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. CANCER RESEARCH, 72, 958-968. Philadelphia, United States of America. 5 year IF=13.678. R/C=20/245, ONCOLOGY.

18.Kimberly Larson^#, Shian-Jang Yan^#, Amy Tsurumi^#, Jacqueline Liu^#, Jun Zhou, Kriti Gaur, Dongdong Guo, Thomas H. Eickbush, Willis X. Li* (2012, Jan). Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genetics, 8(1): 1-10. San Francisco, United States of America. 5 year IF=6.514. R/C=27/175, GENETICS & HEREDITY.

19.Su Liu^#, Shian-Jang Yan^#, Yi-Fen Lee, Ning-Chun Liu, Huei-Ju Ting, Gonghui Li, Qiao Wu, Lu-Min Chen, Chawnshang Chang* (2011, Nov). The testicular nuclear receptor 4 (TR4) regulates UV-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(44):38103-8. Amsterdam, Netherlands. 5 year IF=5.294. R/C=94/297, BIOCHEMISTRY & MOLECULAR BIOLOGY.

20.Shian-Jang Yan, Su Jun Lim, Song Shi, Pranabananda Dutta, Willis X. Li* (2011, Jan). Unphosphorylated STAT and heterochromatin protect genome stability. FASEB JOURNAL, 25, 232-41. Hoboken, United States of America. 5 year IF=6.103. R/C=16/94, BIOLOGY.

21.Shian-Jang Yan, Jeremiah J Zartman, Minjie Zhang, Anthony Scott, Stanislav Y Shvartsman*, Willis X. Li* (2009, Jun). Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Molecular Systems Biology, 5 (278), 1-7. Hoboken, United States of America. 5 year IF=12.904, R/C=20/297, BIOCHEMISTRY & MOLECULAR BIOLOGY.

22.Fan Xia, Jinghong Li, Gavin W Hickey, Amy Tsurumi, Kimberly Larson, Dongdong Guo, Shian-Jang Yan, Louis Silver-Morse, Willis X. Li* (2008, May). Raf activation is regulated by Tyrosine 510 phosphorylation in Drosophila. PLoS Biology, 6, 1115-1129. San Francisco, United States of America. 5 year IF=10.462. R/C=6/94, BIOLOGY.

23.Song Shi, Kimberly Larson, Dongdong Guo, Su Jun Lim, Pranabananda Dutta1, Shian-Jang Yan, Willis X. Li* (2008, Mar). Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. NATURE CELL BIOLOGY, 10, 489-96. London, United Kingdom. 5 year IF=28.123. R/C=9/195, CELL BIOLOGY.

24.Shian-Jang Yan, Yi Gu, Willis X. Li*, Robert J Fleming* (2004, Jan). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development, 131, 285-98. Cambridge, United Kingdom. 5 year IF=7.795. R/C=5/39, DEVELOPMENTAL BIOLOGY.

25.Jiann-Horng Leu, Shian-Jang Yan, Tzuu-Fen Lee, Chih-Ming Chou, Shui-Tsung Chen, Pung-Pung Hwang, Chen-Kung Chou, Chang-Jen Huang* (2000, Jul). Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes. DNA AND CELL BIOLOGY, 19, 431-46. New Rochelle, United States of America. 5 year IF=3.557. R/C=85/175, GENETICS & HEREDITY.

實驗室特色連結

實驗室活動照片連結