吳偉立（Wei-Li Wu）助理教授

學經歷：

中山大學 學士 1997-2001

中山大學 碩士 2001-2003

國防醫學院 生命科學所 （國防醫、國衛院、中研院三院合辦）2005-2011

中研院 博士後研究 2011-2012

加州理工學院 博士後學者 2012-2018

加州理工學院 訪問學者 2018-迄今

成大生理所 助理教授 2018-迄今

專長學科 ：

腸-腦軸研究、腸道微生物與宿主交互關係、行為生理學、神經精神失調動物模式

獎勵事項 ：

2012：最佳壁報論文 National Institutes of Health (NIH) Silvio O. Conte Centers for Basic and Translational Mental Health Retreat, Denver, CO, USA

2011：國科會補助博士後赴國外研究

E-mail

wlwu@mail.ncku.edu.tw

辦公室

82-0717 分機：5458

實驗室

82-0753 分機：5435

嗜好：美食、旅遊、游泳、潛水

研究方向及興趣(影音)：

1.探討腸道微生物對自閉症的影響

2.探討腸道微生物代謝物對壓力的影響

3.利用化學遺傳學探討腸-腦軸的關聯

實驗室成員：

現在成員

博士班：劉嘉瑋（博三）

碩士班： 林元元（碩二） （ ）

助理： 賴姿廷

畢業生

武若婷（M.S.‘21, physiology）、賴姿廷（M.S.‘21, physiology）

相關著作（PubMed連結）

研究論文

Wu, W.L. (Corresponding author), Adame, M.D., Liou, C.W., Barlow, J.T., Lai, T.T., Sharon G., Schretter, C.E., Needham, B.D., Wang, M., Tang, W., Ousey, J., Lin, Y.Y., Yao, T.H., Abdel-Haq, R., Beadle, K., Gradinaru, V., Ismagilov, R.F., Mazmanian, S.K.*, Microbiota regulate social behavior via stress response neurons in the brain. (Nature: Accepted)

Wu, W.L. (Corresponding author), Cheng, S.J., Lin, S.H., Chuang, Y.C., Huang, E.Y., Chen, C.C.*, 2019.The effect of ASIC3 knockout on corticostriatal circuit and mouse self-grooming behavior. Frontiers in Cellular Neuroscience: 13:86. doi: 10.3389/fncel.2019.00086.eCollection 2019.

Lee, Y.K., Mehrabian, P., Boyajian, S., Wu, W.L., Selicha, J., Vonderfecht, S., Mazmanian, S.K.*, 2018. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere, 3(6). pii: e00587-18. doi: 10.1128/mSphere.00587-18..

Ko, J., Isas, J.M., Sabbaugh, A., Yoo, J.H., Pandey, N.K., Chongtham, A., Ladinsky, M., Wu, W.L., Rohweder, H., Weiss, A., Macdonald, D., Munoz-Sanjuan, I., Langen, R., Patterson, P.H., Khoshnan, A., 2018. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human molecular genetics, 27, 2330-2343.

Needham, B.D., Tang, W., Wu, W.L. (Corresponding author), 2017. Searching for the gut microbial contributing factors to social behavior in rodent models.Developmental Neurobiology,78, 474-499.

Wu, W.L. (Corresponding author), 2017. Association among gut microbes, intestinal physiology, and autism.EBioMedicine,25. 11-12.

Chan, K.Y., Jang, M.J., Yoo, B.B., Greenbaum, A., Ravi, N., Wu, W.L.,Óscar Sánchez-Guardado, L., Lois, C., Mazmanian, S.K., Deverman, B.E.*, Gradinaru, V.*, 2017. Engineered adeno-associated viruses for efficient and noninvasive gene delivery throughout the central and peripheral nervous systems.Nature Neuroscience,20, 1172-1179.

Wu, W.L. (Corresponding author), Hsiao, E.Y., Yan, Z., Mazmanian, S.K., Patterson, P.H., 2017. The placental interleukin-6 signaling controls fetal brain development and behavior.Brain, Behavior, and Immunity. 62, 11-23

Highlighted in: Brain, Behavior, and Immunity. 62: 9-10.

Chu, H.*, Khosravi, A., Kusumawardhani, I.P., Kwon, A.H., Vasconcelos, A.C., Cunha, L.D., Mayer, A.E., Shen, Y., Wu, W.L., Kambal, A., Targan, S.R., Xavier, R.J., Ernst, P.B., Green, D.R., McGovern, D.P., Virgin, H.W., Mazmanian, S.K.*, 2016. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.Science, 352, 1116-1120.

Chow, K.H., Yan, Z., Wu, W.L. (Corresponding author), 2016. Induction of maternal immune activation in mice at mid-gestation stage with viral mimic poly(I:C). Journal of Visualized Experiments : JoVE, e53643.

Deverman, B.E.*, Pravdo, P.L., Simpson, B.P., Kumar, S.R., Chan, K.Y., Banerjee, A., Wu, W.L., Yang, B., Huber, N., Pasca, S.P., Gradinaru, V.*, 2016. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.Nature Biotechnology, 34, 204-209.

Wu, W.L. (Corresponding author), Adams, C.E., Stevens, K.E., Chow, K.H., Freedman, R., Patterson, P.H., 2015. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring.Brain, Behavior, and Immunity, 46, 192-202.

Wu, W.L., Cheng, C.F., Sun, W.H., Wong, C.W., Chen, C.C.*, 2012. Targeting ASIC3 for pain, anxiety, and insulin resistance.Pharmacology & Therapeutics, 134, 127-138.

Wu, W.L., Lin, Y.W., Min, M.Y., Chen, C.C.*, 2010. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression.Genes, Brain and Behavior, 9, 603-614.

Wu, W.L., Wang, C.H., Huang, E.Y., Chen, C.C.*, 2009. Asic3(-/-) female mice with hearing deficit affects social development of pups.PLoS One, 4, e6508.

Lin, Y.W., Min, M.Y., Lin, C.C., Chen, W.N., Wu, W.L., Yu, H.M., Chen, C.C.*, 2008. Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3.Neuroscience, 151, 544-557.

Liu, R.T., Chen, Y.J., Chou, F.F., Li, C.L., Wu, W.L., Tsai, P.C., Huang, C.C., Cheng, J.T.*, 2005. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan.Clinical Endocrinology, 63, 461-466.

書本章節

Malkova N., Wu, W.L. (Co-first author), Hsiao, E. Y., 2015. Modeling the Maternal Immune Activation Risk Factor for Schizophrenia.Modeling the Psychopathological Dimensions of Schizophrenia, eds Pletnikov, M., Waddington, J. (Elsevier).

研討會論文

Deverman, B.E. and Pravdo, P.L. and Simpson, B.P. and Kumar, S.R. and Luo, Y. and Chan, K.Y. and Banerjee, A. and Wu, W.L. and Yang, B. and Huber, N. and Pasca, S.P. and Gradinaru, V. (2016) Using Cre-Dependent In Vivo Selection to Identify AAV Variants That Enable Efficient and Widespread Gene Transfer to the Adult Central Nervous System.Molecular Therapy, 24 (S1). S99. ISSN 1525-0016.

Wu, W.L. and Hsiao, E.Y. and Yan, Z. and Mazmanian, S.K. and Patterson, P.H. (2015) Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation.Schizophrenia Bulletin, 41 (S1). Art. No. S216. ISSN 0586-7614.

Wu, W.L. and Adams, C. E. and Stevens, K.E. and Freedman, R. and Patterson, P.H. (2015) Nicotinic Cholinergic Modulation of the Fetal Brain Response to Maternal Immune Activation.Schizophrenia Bulletin, 41 (S1). S216. ISSN 0586-7614.

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