吳偉立副教授

吳偉立（Wei-Li Wu）副教授
		學經歷：中山大學學士 1997-2001 中山大學碩士 2001-2003 國防醫學院生命科學所（國防醫、國衛院、中研院三院合辦）2005-2011 中研院博士後研究 2011-2012 加州理工學院博士後學者 2012-2018 加州理工學院訪問學者 2018-2021 成大生理所助理教授 2018-2023 成大生理所副教授 2023
專長學科：腸-腦軸研究、腸道微生物與宿主交互關係、行為生理學、神經精神失調動物模式
獎勵事項： 2023.04 國立成功大學醫學院「2021年最佳論文獎」；2022.12 財團法人成杏文教基金會「成杏優秀論文獎特別獎」；2022.1 國立成功大學醫學系「醫學系教學優良教師」；2022.09 國立成功大學「111學年度國際頂尖期刊獎」；2021.12 台灣生技醫藥發展基金會「第一屆吳火獅醫學獎」； 2021.09 國立成功大學「110學年度國際頂尖期刊獎」；110學年度國立成功大學醫學院生理所「教學優良教師」；；109學年度國立成功大學醫學院生理所「教學優良教師」
E-mail	wlwu@ncku.edu.tw
辦公室	82-0717 分機：5458		實驗室	82-0753 分機：5435
嗜好：美食、旅遊
研究方向及興趣(影音)：
1.探討腸道微生物對自閉症的影響 2.探討腸道微生物代謝物對壓力的影響 3.探討腸-腦軸的連結
實驗室網站：https://sites.google.com/view/wlwu/home
實驗室成員：
現在成員博士班：賴姿廷、蔡于宣碩士班：姚子宣、文心玫、鄭如晴、李家維畢業生劉嘉瑋 (Ph.D. ‘24, Basic Medical Sciences)、武若婷（M.S.‘21, physiology）、賴姿廷（M.S.‘21, physiology）、林元元（M.S.‘21, physiology）、蔡于宣（M.S.‘23, physiology）、薛家滎（M.S.‘23, physiology）
相關著作（PubMed連結）
研究論文 PUBLICATIONS * corresponding author Lai TT, Tsai YH, Liou CW, Fan CH, Hou YT, Yao TH, Chuang HL, Wu WL. The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling. NPJ Biofilms and Microbiomes. 2024 Jan 16;10(1):2. doi: 10.1038/s41522-024-00477-w. PMID: 38228675. SpringerNature Research Communities Blog Post/Behind the paper: New research unveiling the invisible puppeteers: how our gut microbiota pulls the strings on host locomotion. https://go.nature.com/3tYXa6j Lai TT, Liou CW, Tsai YH, Lin YY, Wu WL. Butterflies in the gut: the interplay between intestinal microbiota and stress. Journal of Biomedical Science. 2023 Nov 28;30(1):92. doi: 10.1186/s12929-023-00984-6. PMID: 38012609; PMCID: PMC10683179. Liou CW, Cheng SJ, Yao TH, Lai TT, Tsai YH, Chien CW, Kuo YL, Chou SH, Hsu CC, Wu WL. Microbial metabolites regulate social novelty via CaMKII neurons in the BNST. Brain Behavior and Immunity. 2023 Oct;113:104-123. doi: 10.1016/j.bbi.2023.06.029. Epub 2023 Jun 29. PMID: 37393058. Liou, C.W., Yao, Z.H., Wu, W.L., 2022. Intracerebroventricular delivery of gut-derived microbial metabolites in mice. Journal of Visualized Experiments : JoVE. Jun 2;(184). doi: 10.3791/63972. PMID: 35723471. Wu, J.T., Sun, C.L., Lai, T.T., Liou, C.W., Lin, Y.Y., Xue, J.Y., Wang, H.W., Chai, L.M.X., Lee, Y.J., Chen, S.L., Chang, A.Y.W., Hung, J.H., Hsu, C.C., Wu, W.L., 2022. Oral short-chain fatty acids administration regulates innate anxiety in adult microbiome-depleted mice. Neuropharmacology. Aug 15;214:109140. doi: 10.1016/j.neuropharm.2022.109140. Epub 2022 May 22. PMID: 35613660. Needham, B.D., Funabashi, M., Adame, M.D., Wang, Z., Boktor, J., Haney, J., Wu, W.L., Rabut, C., Ladinsky, M.S., Hwang, S.J., Guo, Y., Griffiths, J.A., Knight, R., Bjorkman, P.J., Shapiro, M.G., Geschwind, D.H., Holschneider, D.P., Fischbach, M.A., Mazmanian, S.K., 2022. A gut-derived metabolite alters brain activity and anxiety behavior in mice. Nature 602, 647–653 https://doi.org/10.1038/s41586-022-04396-8 Wu, W.L., Adame, M.D., Liou, C.W., Barlow, J.T., Lai, T.T., Sharon G., Schretter, C.E., Needham, B.D., Wang, M.I., Tang, W., Ousey, J., Lin, Y.Y., Yao, T.H., Abdel-Haq, R., Beadle, K., Gradinaru, V., Ismagilov, R.F., Mazmanian, S.K., 2021. Microbiota regulate social behavior via stress response neurons in the brain. Nature 595, 409-414 https://doi.org/10.1038/s41586-021-03669-y Wu, W.L., Cheng, S.J., Lin, S.H., Chuang, Y.C., Huang, E.Y., Chen, C.C., 2019. The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Frontiers in Cellular Neuroscience, 13:86. doi: 10.3389/fncel.2019.00086.eCollection 2019. Lee YK, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK., 2018. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere, 3, e00587-18. doi: 10.1128/mSphere.00587-18. Ko, J., Isas, J.M., Sabbaugh, A., Yoo, J.H., Pandey, N.K., Chongtham, A., Ladinsky, M., Wu, W.L., Rohweder, H., Weiss, A., Macdonald, D., Munoz-Sanjuan, I., Langen, R., Patterson, P.H., Khoshnan, A., 2018. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human molecular genetics, 27, 2330-2343. Needham, B.D., Tang, W., Wu, W.L., 2018. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Developmental Neurobiology, 78, 474-499. Wu, W.L., 2017. Association among gut microbes, intestinal physiology, and autism. EBioMedicine, 25. 11-12. Chan, K.Y., Jang, M.J., Yoo, B.B., Greenbaum, A., Ravi, N., Wu, W.L., Óscar Sánchez-Guardado, L., Lois, C., Mazmanian, S.K., Deverman, B.E., Gradinaru, V., 2017. Engineered adeno-associated viruses for efficient and noninvasive gene delivery throughout the central and peripheral nervous systems. Nature Neuroscience, 20, 1172-1179. Wu, W.L., Hsiao, E.Y., Yan, Z., Mazmanian, S.K., Patterson, P.H., 2017. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain, Behavior, and Immunity. 62, 11-23 (Highlighted in: Brain, Behavior, and Immunity. 62: 9-10.) Chu, H., Khosravi, A., Kusumawardhani, I.P., Kwon, A.H., Vasconcelos, A.C., Cunha, L.D., Mayer, A.E., Shen, Y., Wu, W.L., Kambal, A., Targan, S.R., Xavier, R.J., Ernst, P.B., Green, D.R., McGovern, D.P., Virgin, H.W., Mazmanian, S.K., 2016. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science, 352, 1116-1120. Chow, K.H., Yan, Z., Wu, W.L., 2016. Induction of maternal immune activation in mice at mid-gestation stage with viral mimic poly(I:C). Journal of Visualized Experiments : JoVE, e53643. Deverman, B.E., Pravdo, P.L., Simpson, B.P., Kumar, S.R., Chan, K.Y., Banerjee, A., Wu, W.L., Yang, B., Huber, N., Pasca, S.P., Gradinaru, V., 2016. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nature Biotechnology, 34, 204-209. Wu, W.L., Adams, C.E., Stevens, K.E., Chow, K.H., Freedman, R., Patterson, P.H., 2015. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain, Behavior, and Immunity, 46, 192-202. Wu, W.L., Cheng, C.F., Sun, W.H., Wong, C.W., Chen, C.C., 2012. Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacology & Therapeutics, 134, 127-138. Wu, W.L., Lin, Y.W., Min, M.Y., Chen, C.C., 2010. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes, Brain and Behavior, 9, 603-614. Wu, W.L., Wang, C.H., Huang, E.Y., Chen, C.C., 2009. Asic3(-/-) female mice with hearing deficit affects social development of pups. PLoS One, 4, e6508. Lin, Y.W., Min, M.Y., Lin, C.C., Chen, W.N., Wu, W.L., Yu, H.M., Chen, C.C., 2008. Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3. Neuroscience, 151, 544-557. Liu, R.T., Chen, Y.J., Chou, F.F., Li, C.L., Wu, W.L., Tsai, P.C., Huang, C.C., Cheng, J.T., 2005. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clinical Endocrinology, 63, 461-466. BOOK Malkova N., Wu, W.L. (Co-first author), Hsiao, E. Y., 2015. Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. Modeling the Psychopathological Dimensions of Schizophrenia, eds Pletnikov, M., Waddington, J. (Elsevier). CONFERENCE PAPERS Deverman, B.E. and Pravdo, P.L. and Simpson, B.P. and Kumar, S.R. and Luo, Y. and Chan, K.Y. and Banerjee, A. and Wu, W.L. and Yang, B. and Huber, N. and Pasca, S.P. and Gradinaru, V. (2016) Using Cre-Dependent In Vivo Selection to Identify AAV Variants That Enable Efficient and Widespread Gene Transfer to the Adult Central Nervous System. Molecular Therapy, 24 (S1). S99. ISSN 1525-0016. Wu, W.L. and Hsiao, E.Y. and Yan, Z. and Mazmanian, S.K. and Patterson, P.H. (2015) Maternal Immune Activation Perturbs Fetal Brain Development and Adult Behaviors Through Placental Trophoblast IL-6 Activation. Schizophrenia Bulletin, 41 (S1). Art. No. S216. ISSN 0586-7614. Wu, W.L. and Adams, C. E. and Stevens, K.E. and Freedman, R. and Patterson, P.H. (2015) Nicotinic Cholinergic Modulation of the Fetal Brain Response to Maternal Immune Activation. Schizophrenia Bulletin, 41 (S1). S216. ISSN 0586-7614.
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