研究經歷：

國立成功大學生理所, 台灣 / 副教授 / 2023-

國立成功大學生理所, 台灣 / 助理教授 / 2018-2023

加州理工學院, 美國 / 訪問學者 / 2018-2021

加州理工學院, 美國 / 博士後研究 / 2012-2018

中央研究院生醫所, 台灣 / 博士後研究 / 2011-2012

學會：

EMBO 全球研究學者 / 成員 / 2025-2028

台灣基礎神經科學學會 / 理事 / 2022-2026

中國生理學會 (CPS) / 國際事務暨生理醫學教育委員會 / 2020-2026

中國生理學會 (CPS) / 學術委員會 / 2020-2024

學歷：

博士 / 國防醫學院, 台灣

碩士 / 國立中山大學, 台灣

學士 / 國立中山大學, 台灣

專長學科 ：

神經生物學、腸-腦軸研究、腸道微生物體學、行為生理學

研究方向 (介紹影片)：

1. 解碼腸腦軸中的微生物訊號

2. 探討腸道微生物如何透過腸-腦軸在壓力及威脅反應的調控

研究榮譽/獎項：

2024 財團法人成杏文教基金會「成杏優秀論文獎」

2024 歐洲分子生物學組織 (EMBO) 全球研究學者 (2025-2028)

2023 國科會 2030跨世代年輕學者方案 - 國際年輕傑出學者 (2023-2027)

2012 國科會 千里馬計畫 補助赴國外從事博士後研究

教學榮譽/獎項：

2022 國立成功大學醫學系 「醫學系教學優良教師」

2021 國立成功大學醫學院生理所「教學優良教師」

2020 國立成功大學醫學院生理所「教學優良教師」

E-mail

  wlwu@ncku.edu.tw

辦公室

  82-0717 分機：5458

實驗室

  82-0753 分機：5435

住址 ：

701 台灣臺南市大學路1號 成杏校區醫學院研究大樓7樓生理學科暨研究所 82-0717

嗜好 ：

美食、廚藝、旅遊

實驗室成員：想了解目前組成及畢業論文請點我 

目前成員

畢業生

劉嘉瑋 (PhD‘24, Basic Medical Sciences) (2018.09-2024.02)

康恩宇 (PhD‘22, TIGP-INS) (與陳志成老師共同指導) (2018-2022)

實驗室發表文獻連結： 論文連結請點我 (PubMed)

* 通訊作者

SCI 論文著作

• Lai TT, Tsai YH, Liou CW, Fan CH, Hou YT, Yao TH, Chuang HL, Wu WL*. The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling. NPJ Biofilms and Microbiomes. 2024 Jan 16;10(1):2. doi: 10.1038/s41522-024-00477-w. PMID: 38228675.
  • SpringerNature Research Communities Blog Post/Behind the paper: New research unveiling the invisible puppeteers: how our gut microbiota pulls the strings on host locomotion. https://go.nature.com/3tYXa6j
• Lai TT, Liou CW, Tsai YH, Lin YY, Wu WL*. Butterflies in the gut: the interplay between intestinal microbiota and stress. Journal of Biomedical Science. 2023 Nov 28;30(1):92. doi: 10.1186/s12929-023-00984-6. PMID: 38012609; PMCID: PMC10683179.
• Liou CW, Cheng SJ, Yao TH, Lai TT, Tsai YH, Chien CW, Kuo YL, Chou SH, Hsu CC, Wu WL*. Microbial metabolites regulate social novelty via CaMKII neurons in the BNST. Brain Behavior and Immunity. 2023 Oct;113:104-123. doi: 10.1016/j.bbi.2023.06.029. Epub 2023 Jun 29. PMID: 37393058.
• Liou, C.W.*, Yao, Z.H., Wu WL*, 2022. Intracerebroventricular delivery of gut-derived microbial metabolites in mice. Journal of Visualized Experiments : JoVE. Jun 2;(184). doi: 10.3791/63972. PMID: 35723471.
• Wu, J.T., Sun, C.L., Lai, T.T., Liou, C.W., Lin, Y.Y., Xue, J.Y., Wang, H.W., Chai, L.M.X., Lee, Y.J., Chen, S.L., Chang, A.Y.W., Hung, J.H., Hsu, C.C., Wu WL*, 2022. Oral short-chain fatty acids administration regulates innate anxiety in adult microbiome-depleted mice. Neuropharmacology. Aug 15;214:109140. doi: 10.1016/j.neuropharm.2022.109140. Epub 2022 May 22. PMID: 35613660.
• Needham, B.D.*, Funabashi, M., Adame, M.D., Wang, Z., Boktor, J., Haney, J., Wu WL, Rabut, C., Ladinsky, M.S., Hwang, S.J., Guo, Y., Griffiths, J.A., Knight, R., Bjorkman, P.J., Shapiro, M.G., Geschwind, D.H., Holschneider, D.P., Fischbach, M.A., Mazmanian, S.K.*, 2022. A gut-derived metabolite alters brain activity and anxiety behavior in mice. Nature 602, 647–653 https://doi.org/10.1038/s41586-022-04396-8
• Wu WL*, Adame, M.D., Liou, C.W., Barlow, J.T., Lai, T.T., Sharon G., Schretter, C.E., Needham, B.D., Wang, M.I., Tang, W., Ousey, J., Lin, Y.Y., Yao, T.H., Abdel-Haq, R., Beadle, K., Gradinaru, V., Ismagilov, R.F., Mazmanian, S.K.*, 2021. Microbiota regulate social behavior via stress response neurons in the brain. Nature 595, 409-414 https://doi.org/10.1038/s41586-021-03669-y
• Wu WL*, Cheng, S.J., Lin, S.H., Chuang, Y.C., Huang, E.Y., Chen, C.C.*, 2019. The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior. Frontiers in Cellular Neuroscience, 13:86. doi: 10.3389/fncel.2019.00086.eCollection 2019.
• Lee YK, Mehrabian P, Boyajian S, Wu WL, Selicha J, Vonderfecht S, Mazmanian SK., 2018. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere, 3, e00587-18. doi: 10.1128/mSphere.00587-18.
• Ko, J., Isas, J.M., Sabbaugh, A., Yoo, J.H., Pandey, N.K., Chongtham, A., Ladinsky, M., Wu WL, Rohweder, H., Weiss, A., Macdonald, D., Munoz-Sanjuan, I., Langen, R., Patterson, P.H., Khoshnan, A., 2018. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human molecular genetics, 27, 2330-2343.
• Needham, B.D., Tang, W., Wu WL*, 2018. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Developmental Neurobiology, 78, 474-499.
• Wu WL*, 2017. Association among gut microbes, intestinal physiology, and autism. EBioMedicine, 25. 11-12.
• Chan, K.Y., Jang, M.J., Yoo, B.B., Greenbaum, A., Ravi, N., Wu WL, Óscar Sánchez-Guardado, L., Lois, C., Mazmanian, S.K., Deverman, B.E.*, Gradinaru, V.*, 2017. Engineered adeno-associated viruses for efficient and noninvasive gene delivery throughout the central and peripheral nervous systems. Nature Neuroscience, 20, 1172-1179.
• Wu WL*, Hsiao, E.Y., Yan, Z., Mazmanian, S.K., Patterson, P.H., 2017. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain, Behavior, and Immunity. 62, 11-23
  • Highlighted in: Brain, Behavior, and Immunity. 62: 9-10.
• Chu, H.*, Khosravi, A., Kusumawardhani, I.P., Kwon, A.H., Vasconcelos, A.C., Cunha, L.D., Mayer, A.E., Shen, Y., Wu WL, Kambal, A., Targan, S.R., Xavier, R.J., Ernst, P.B., Green, D.R., McGovern, D.P., Virgin, H.W., Mazmanian, S.K.*, 2016. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science, 352, 1116-1120.
• Chow, K.H., Yan, Z., Wu WL*, 2016. Induction of maternal immune activation in mice at mid-gestation stage with viral mimic poly(I:C). Journal of Visualized Experiments : JoVE, e53643.
• Deverman, B.E.*, Pravdo, P.L., Simpson, B.P., Kumar, S.R., Chan, K.Y., Banerjee, A., Wu WL, Yang, B., Huber, N., Pasca, S.P., Gradinaru, V.*, 2016. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nature Biotechnology, 34, 204-209.
• Wu WL*, Adams, C.E., Stevens, K.E., Chow, K.H., Freedman, R., Patterson, P.H., 2015. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain, Behavior, and Immunity, 46, 192-202.
• Wu WL, Cheng, C.F., Sun, W.H., Wong, C.W., Chen, C.C.*, 2012. Targeting ASIC3 for pain, anxiety, and insulin resistance. Pharmacology & Therapeutics, 134, 127-138.
• Wu WL, Lin, Y.W., Min, M.Y., Chen, C.C.*, 2010. Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. Genes, Brain and Behavior, 9, 603-614.
• Wu WL, Wang, C.H., Huang, E.Y., Chen, C.C.*, 2009. Asic3(-/-) female mice with hearing deficit affects social development of pups. PLoS One, 4, e6508.
• Lin, Y.W., Min, M.Y., Lin, C.C., Chen, W.N., Wu WL, Yu, H.M., Chen, C.C.*, 2008. Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3. Neuroscience, 151, 544-557.
• Liu, R.T., Chen, Y.J., Chou, F.F., Li, C.L., Wu WL, Tsai, P.C., Huang, C.C., Cheng, J.T.*, 2005. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clinical Endocrinology, 63, 461-466.