楊尚訓（Shang-Hsun Yang）教授 (Google Scholar) (Research NCKU)

學經歷：

中興大學 學士，1994-1998

台灣大學 碩士，1998-2000

美國艾默里(Emory)大學 博士，2005-2008

成大生理所 助理教授，2009-2013

成大生理所 副教授，2013-2017

成大生理所 教授，2017-迄今

專長學科 ：

神經退化性疾病、神經科學、分子生物學、繁殖生理學、胚胎學

獎勵事項 ：

2019: 成杏優秀論文獎

2018: 成杏優秀論文獎

2017: 科技部未來科技突破獎

2016: 科技部吳大猶先生紀念獎

2016 : 李國鼎研究獎

2015 : 第10屆永信李天德醫藥青年醫藥科技獎

2014 : 成杏優秀論文獎

2014 : 國立成功大學 校教學傑出教師

2014 : 國立成功大學 醫學院 基礎醫學組 最佳論文獎

2013 : 國立成功大學 醫學院 基礎醫學研究獎

2013 : 臺綜大「臺綜大年輕學者創意競賽」優等獎

E-mail

syang@mail.ncku.edu.tw

辦公室

82-0712 分機：5453

實驗室

82-0751 分機：5433

嗜好：旅遊，運動，陪小孩玩

研究方向及興趣：

1. 利用新穎基因轉殖技術建立人類疾病動物模式

2. 探討microRNA於神經退化性疾病的影響，及其對神經保護的調控機制與應用於基因治療的可行性

3. 應用胚胎及幹細胞探討神經發育及保護機制

4. 利用基因轉殖小鼠探討microRNA 的基因調控機制

實驗室成員：

現在成員

徵博士後研究員（面試通過起聘）

博士班：童志偉（2022,2-）、曾秀珍（2022,8-）

碩士班：陳憶晴（碩二）、蘇靖淳（碩一）

助理：鄭佩薰

過去成員

博士後：許哲裕(2022)

博士班：李佳玲（2010,9-2015,1）、Issa Olakunle Yusuf(2015,9-2019,1)

碩士班：童筠璇（2022-2024）、黃品優（2020-2022）、曾秀珍（2019-2021）、楊涵茵（2016-2018）、林佳葳（2016-2018）、毛姝涵（2014-2016）、湯婷羽（2013-2015）、張玉綾（2013-2015）、張智怡（2012-2014）、施孟奇（2012-2014）、林建宇（2011-2013）

助理：張于凡（2011-2017）、陳秀梅（2017-2018）、張智怡（2017-2019）、林冠妤(2020)

相關著作（PubMed連結）

Chan SC, Tung CW, Lin CW, Tung YS, Wu PM, Cheng PC, Chen CM, Yang SH*. 2023. miR-196a provides antioxidative neuroprotection via USP15/Nrf2 regulation in Huntington's disease. Free Radic Biol Med. 209(Pt 2):292-300.

Chang MM, Weng HY, Lai MS, Wang LW, Yang SH, Wu CC, Wang CY, Huang BM. 2022. FGF9 promotes cell proliferation and tumorigenesis in TM3 mouse Leydig progenitor cells. Am J Cancer Res. 12(12):5613-5630.

Lin CC, Chuang KC, Chen SW, Chao YH, Yen CC, Yang SH, Chen W, Chang KH, Chang YK, Chen CM. 2022. Lactoferrin Ameliorates Ovalbumin-Induced Asthma in Mice through Reducing Dendritic-Cell-Derived Th2 Cell Responses. Int J Mol Sci. ;23(22):14185.

Yang HI, Huang PY, Chan SC, Tung CW, Cheng PC, Chen CM, Yang SH*. 2022. miR-196a enhances polymerization of neuronal microfilaments through suppressing IMP3 and upregulating IGF2 in Huntington’s disease. Mol Ther Nucleic Acids. 30: 286-299.

Ching SH, Chiu YC, Liao YC, Yang SH*, Tsai YJ. 2022. A new mouse model of ankle instability induced by multiple mechanical sprains with controlled inversion angle and speed. Front Bioeng Biotechnol.10:927987.

Chan AW, Cho IK, Li CX, Zhang X, Patel S, Rusnak R, Raper J, Bachevalier J, Moran SP, Chi T, Cannon KH, Hunter CE, Martin RC, Xiao H, Yang SH, Gumber S, Herndon JG, Rosen RF, Hu WT, Lah JJ, Levey AI, Smith Y, Walker LC. 2022. Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey. Aging Brain. 2, 100044.

Ou-Yang H, Yang SH, Chen W, Yang SH, Cidem A, Sung LY, Chen CM. 2022. Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals. Int J Mol Sci. 23(7):3973.

Chen CF, Li HP, Chao YH, Tu MY, Yen CC, Lan YW, Yang SH, Chong KY, Lin CC, Chen CM. 2021. Suppression of Dendritic Cell Maturation by Kefir Peptides Alleviates Collagen-Induced Arthritis in Mice. Front Pharmacol. 12:721594.

Tung CW, Huang PY, Chan SC, Cheng PH, Yang SH*. 2021. The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease. J Biomed Sci. 28(1):59.

Chen YY, Chen CH, Lin WC, Tung CW, Chen YC, Yang SH*, Huang BM*, Chen RJ*. 2021. The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin. Molecules. 26(16): 4954.

Ou-Yang H, Wu SC, Sung LY, Yang SH, Yang SH, Chong KY, Chen CM. 2021. STAT3 Is an Upstream Regulator of Granzyme G in the Maternal-To-Zygotic Transition of Mouse Embryos. Int J Mol Sci. 5;22(1):460.

Yusuf IO, Chen HM, Cheng PH, Chang CY, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Chen CM, Yang SH*. 2021. Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington's Disease Models. Mol Neurobiol. 58(5):2396-2406.

Yusuf IO, Chen HM, Cheng PH, Chang CY, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Chen CM, Yang SH*. 2021. FGF9 induces neurite outgrowth upon ERK signaling in knock-in striatal Huntington's disease cells. Life Sci. 267:118952.

Chang MM, Hong SY, Yang SH, Wu CC, Wang CY, Huang BM. 2020. Anti-Cancer Effect of Cordycepin on FGF9-Induced Testicular Tumorigenesis. Int J Mol Sci. 21(21):8336.

Li YH, Chen TM, Huang BM, Yang SH, Wu CC, Lin YM, Chuang JI, Tsai SJ, Sun HS. 2020. FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture. Biol Reprod. 103(6):1300-1313.

Yang SH, Huang CY, Hsieh CY, Chuang JI. 2020. CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP. Mol Neurobiol. 57(10):4090-4105.

Huang CW, Lu SY, Huang TC, Huang BM, Sun HS, Yang SH, Chuang JI, Hsueh YY, Wu YT, Wu CC. 2020. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics 10(6):2817-2831.

Yen CC, Chang WH, Tung MC, Chen HL, Liu HC, Liao CH, Lan YW, Chong KY, Yang SH, Chen CM. 2019. Lactoferrin Protects Hyperoxia-Induced Lung and Kidney Systemic Inflammation in an In Vivo Imaging Model of NF-κB/Luciferase Transgenic Mice. Mol Imaging Biol. 22(3):526-538.

Yusuf IO, Chen HM, Cheng PH, Chang CY, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Yang SH*. 2019. Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease. Free Radic Biol Med. 130: 256-266.

Chang MM, Lai MS, Hong SY, Pan BS, Huang HY, Yang SH, Wu CC, Sun H, Chuang JI, Wang CY, Huang BM. 2018. FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1 and cell cycle pathways in mouse Leydig tumor cells. Cancer Science. 109(11):3503-3518

Yusuf IO, Cheng PH, Chen HM, Chang YF, Chang CY, Yang HI, Lin CW, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Yang SH*. 2018. Fibroblast growth factor 9 suppresses striatal cell death dominantly through ERK signaling in Huntington's Disease. Cell Physiol Biochem. 48(2):605-617.

Lai HY, Hsu LW, Tsai HH, Lo YC, Yang SH, Liu PY, Wang JM. 2017. CCAAT/enhancer-binding protein delta promotes intracellular lipid accumulation in M1 macrophages of vascular lesions. Cardiovasc Res. 113(11):1376-1388.

Her LS, Mao SH, Chang CY, Cheng PH, Chang YF, Yang HI, Chen CM, Yang SH*. 2017. miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington’s disease. Theranostics. 7(9):2452-2462.

Hsu JY, Jhang YL, Cheng PC, Chang YF, Mao SH, Yang HI, Lin CW, Chen CM, Yang SH*. 2017. The truncated C-terminal fragment of mutant ATXN3 disrupts mitochondria dynamics in Spinocerebellar ataxia type 3 models. Front Mol Neurosci 10:196.

Lai CW, Chen HL, Tu MY, Lin WY, Röhrig T, Yang SH, Lan YW, Chong KY, Chen CM. 2017. A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice. Oncotarget. 8(5):7357-7369.

Cheng PH, Chang YF, Mao SH, Lin HL, Chen CM, Yang SH*. 2016. Lentiviral transgenesis in mice via a simple method of viral concentration. Theriogenology. 86(6):1427-35.

Lai CW, Chen HL, Yen CC, Wang JL, Yang SH, Chen CM. 2016. Using Dual Fluorescence Reporting Genes to Establish an In Vivo Imaging Model of Orthotopic Lung Adenocarcinoma in Mice. Mol Imaging Biol. 18(6):849-859

Lai CW, Chen HL, Tsai TC, Chu TW, Yang SH, Chong KY, Chen CM. 2016. Sexually Dimorphic Expression of eGFP Transgene in the Akr1A1 Locus of Mouse Liver Regulated by Sex Hormone-Related Epigenetic Remodeling. Sci Rep. 6:24023.

Lai MS, Wang CY, Yang SH, Wu CC, Sun HS, Tsai SJ, Chuang JI, Chen YC, Huang BM. 2016. The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis. 14:1-17.

Tsai SW, Tung YT, Chen HL, Yang SH, Liu CY, Lu M, Pai HJ, Lin CC, Chen CM. 2016. Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation. Life Sci. 146:15-23.

Fu MH, Li CL, Lin HL, Chen PC, Calkins MJ, Chang YF, Cheng PH, Yang SH*. 2015. Stem cell transplantation therapy in Parkinson's disease. Springerplus; 4:597.

Hsueh YY, Chang YJ, Huang CW, Handayani F, Chiang YL, Fan SC, Ho CJ, Kuo YM, Yang SH, Chen YL, Lin SC, Huang CC, Wu CC. 2015. Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury. Sci Rep. 5:14985.

Hsiao KY, Wu MH, Chang N, Yang SH, Wu CW, Sun HS, Tsai SJ. 2015. Coordination of AUF1 and miR-148a to destabilize DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod. 21(12):894-904.

Chuang JI, Huang JY, Tsai SJ, Sun HS, Yang SH, Chuang PC, Huang BM, Ching CH. 2015. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med. 89:274-286.

Fu MH, Li CL, Lin HL, Tsai SJ, Lai YY, Chang YF, Cheng PH, Chen CM, Yang SH*. 2015. The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One. 10(9): e0137637.

Kuo CW, Shen CJ, Tung YT, Chen HL, Chen YH, Chang WH, Cheng KC, Yang SH, Chen CM. 2015. Extracellular superoxide dismutase ameliorates streptozotocin-induced rat diabetic nephropathy via inhibiting the ROS/ERK1/2 signaling. Life Sci. 135:77-86.

Her LS, Lin JY, Fu MH, Chang YF, Li CL, Tang TY, Jhang YL, Chang CY, Shih MC, Cheng PH, Yang SH*. 2015. The differential profiling of ubiquitin-proteasome and autophagy systems in different tissues before the onset of Huntington’s disease models. Brain Pathol. 25(4):481-90.

Chen Y, Zheng Y, Kang Y, Yang W, Niu Y, Guo X, Tu Z, Si C, Wang H, Xing R, Pu X, Yang SH, Li S, Ji W, Li XJ. 2015. Functional disruption of the dystrophin gene in Rhesus Monkey Using CRISPR/Cas9. Hum Mol Genet. 24(13):3764-74.

Niu Y, Guo X, Chen Y, Wang CE, Gao J, Yang W, Kang Y, Si W, Wang H, Yang SH, Li S, Ji W, Li XJ. 2015. Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. Hum Mol Genet. 15;24(8):2308-17

Wang CY, Yang SH, Tzeng SF. 2015. MicroRNA-145 as one negative regulator of astrogliosis. Glia. 63(2):194-205.

Chang WF, Xu J, Chang CC, Yang SH, Li HY, Hsieh-Li HM, Tsai MH, Wu SC, Cheng WT, Liu JL, Sung LY. 2015. SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice. Brain Struct. Funct. 220(3):1539-53

Liu HC, Pai SY, Chen HL, Lai CW, Tsai TC, Cheng WT, Yang SH, Chen CM. 2014. Recombinant Derp5 allergen with αS1-casein signal peptide secreted in murine milk protects against dust mite allergen-induced airway inflammation. J Dairy Sci. 97(11):6792-803.

Tung YT, Tang TY, Chen HL, Yang SH, Chong KY, Cheng WT, Chen CM. 2014. Lactoferrin protects against chemical-induced rat liver fibrosis through inhibiting stellate cells activation. J. Dairy Sci. 97(6):3281-91.

Cheng PH, Li CL, Chang YF, Tsai SJ, Lai YY, Chan AW, Chen CM, Yang SH*. 2013. MiR-196a ameliorates phenotypes of Huntington Disease in cell, transgenic mouse and induced pluripotent stem cell models. Am J Hum Genet. 93(2): 306–312.

Tung YT, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM. 2013. Therapeutic potential of andrographolide isolated from the leaves of andrographis paniculata nees for treating lung adenocarcinomas. Evid Based Complement Alternat Med: e305898.

Kocerha J, Liu Y, Willoughby D, Chidamparam K, Benito J, Nelson K, Xu Y, Chi T, Engelhardt H, Moran S, Yang SH, Li SH, Li XJ, Larkin K, Neumann A, Banta H, Yang JJ, Chan AW. 2013. Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys. BMC Neurosci 14(1): 88.

Chen YK, Huang AH, Cheng PH, Yang SH*, Lin LM*. 2013. Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias. Clin Oral Investig. 17(3):921-32 (*Co-corresponding author)

Cheng PH, Li CL, Her LS, Chang YF, Chan AW, Chen CM, Yang SH*. 2013. Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein. Brain Struct. Funct. 218(1):283-94.

Lin SC, Wang CC, Wu MH, Yang SH, Li YH, Tsai SJ. 2012. Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab. 97(8):E1515-23

Shen CJ, Cheng WT, Wu SC, Chen HL, Tsai TC, Yang SH, Chen CM. 2012. Differential differences in methylation status of putative imprinted genes among cloned swine genomes. PLoS One 7(2):e32812.

Snyder BR, Cheng PH, Yang J, Yang SH, Huang AH, Chan AW. 2011. Characterization of dental pulp stem/stromal cells of huntington monkey tooth germs. BMC Cell Biol. 12(1):39.

Chen YK, Yang SH, Huang AH, Hsue SS, Lin LM. 2011. Aberrant expression in multiple components of the transforming growth factor-β1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell carcinogenesis. Oral Oncol. 47(4):262-267.

Yang SH, Chan AW.. 2011. Transgenic animal models of huntington's disease. Curr. Top. Behav. Neurosci. 7:61-85.

Tsai TC*, Lin W*, Yang SH*, Cheng WT, Cheng EH, Lee MS, Chong KY, Chen CM. 2010. Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition. BMC Dev. Biol. (10):88. (*Co-first author)

Laowtammathron C, Cheng ECH, Cheng PH, Snyder BR, Yang SH, Johnson Z, Lorthongpanich C, Kuo HC, Parnpai R, Chan AW. 2010. Monkey hybrid stem cells develop cellular features of Huntington's disease. BMC Cell Biol. (11):12.

Liu J, Cheng EC, Long RC, Yang SH, Wang L, Cheng PH, Yang J, Wu D, Mao H, Chan AW. 2009. Noninvasive Monitoring of Embryonic Stem Cells in vivo with MRI Transgene Reporter. Tissue Engineering. 15(4):739-747

Donaldson ZR, Yang SH, Chan AW, Young LJ. 2009. Production of germline transgenic prairie voles (Microtus ochrogaster) using lentiviral vectors. Biol. Reprod. 81(6):1189-1195

Chan AW, Yang SH. 2009. Generation of transgenic monkeys with human inherited genetic disease. Methods 49(1):78-84

Piotrowska-Nitsche K, Yang SH, Banta H, Chan AW. 2009. Assisted fertilization and embryonic axis formation in higher primates. RBM Online 18(3):382-90

Yang SH, Cheng PH, Sullivan RT, Thomas JW, Chan AW. 2008. Lentiviral Integration preferences in transgenic mice. Genesis 46(12):711-718.

Lorthongpanich C, Yang SH, Piotrowska-Nitsche K, Parnpai R, Chan AW. 2008. Chemical enhancement in embryo development and stem cell derivation from single blastomere. Cloning and Stem Cells 10(4):503-512.

Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ 2008. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington’s disease. Hum Mol Genet. 17(17):2738-2751.       

Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW. 2008. Towards a transgenic model of Huntington’s Disease in a non-human primate. Nature 453: 921-924.

Lorthongpanich C, Yang SH, Piotrowska-Nitsche K, Parnpai R, Chan AW. 2008. Development of single mouse blastomeres into blastocysts, outgrowths and the establishment of embryonic stem cells. Reproduction 135(6):805-813.

Yang SH, Agca Y, Cheng PH, Yang JJ, Agca C, Chan AW. 2007. Enhanced transgenesis by intracytoplasmic injection of envelope-free lentivirus. Genesis 45(4):177-83.

Yen CC, Yang SH, Lin CY, Chen CM. 2006. Stem cells in the lung parenchyma and prospects for lung injury therapy. Euro. J. Clin. Invest. 36:310-319

Chen HL, Lai YW, Yen CC, Lin YY, Lu CY, Yang SH, Tsai TC, Lin YJ, Lin CW, Chen CM. 2004. Production of recombinant porcine lactoferrin exhibiting antibacterial activity in methylotrophic yeast, Pichia pastoris. J. Mol. Microbiol. Biotechnol. 8: 141-149.

實驗室校園焦點連結（1)（2）(3) (4)

實驗室活動照片連結 (2011-2015) (2016-迄今)