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孫宏羽 助理教授

孫宏羽（Hung-Yu Sun）助理教授
10

學經歷：

中興大學 動物系 學士 1998-2002

成功大學 分子醫學研究所 碩士 2002-2004

成功大學 基礎醫學研究所 博士2004-2011

成功大學 博士後研究 2012-2018

渥太華大學 訪問學者 2016-2016

成功大學 分子醫學研究所 兼任助理教授 2018-2022

湖南大學 生物學院 教授 2018-2022

成功大學 生理學研究所 助理教授 2022-迄今

專長學科 ：

脂蛋白生理學；非酒精性脂肪肝；宿主代謝與病毒感染；病毒致病機轉

獎勵事項 ：

2017：財團法人肝病防治學術基金會肝病防治優秀論文獎

2013：行政院國家科學委員會博士後研究人員學術著作獎

2012: 台灣微生物學會第二十屆第三次年會口頭發表論文獎（病毒學組）

2011：台灣微生物學會嚴智鍾教授獎學金

E-mail

z11108042@ncku.edu.tw; s5893149@gmail.com

辦公室

82-0705 分機：5420

實驗室

82-0755 

嗜好：慢跑、登山、旅遊、健身

研究方向及興趣(影音)：

1.探討載脂蛋白對代謝性疾病及病毒感染的影響

2.研究壓力誘導載脂蛋白J伴護蛋白對於脂肪代謝的影響

3.開發緩解細胞內脂肪異位沈積的多肽
實驗室網站：

實驗室成員：王欣慈（碩一）

現在成員

博士班：

碩士班： 王欣慈（碩一）

助理： 

畢業生

 

相關著作（PubMed連結）

研究論文(2017-2022)

  1. Cong Wang, Xue Li, Changping Yu, Luoling Wang, Rilin Deng, Yan Xu, Renyun Tian, Shengwen Wen, Hui Liu, Zihao Chen, yingdan zhang, Hungyu Sun, Haizhen Zhu, Jianli Wang, Songqing Tang. RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth. Nature Communications. (Under review)
  2. Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Yen-Cheng Chiu, Sin-Tian Wang, Dyoness Charmaine Tan, Hung-Chih Chiu1, Shih-Chih Chien, Kung-Chia Young. Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. J Microbiol Immunol Infect. S1684-1182(22)00095-0 (Co-first author)
  3. Shu-Fang Hsieh, Hung-Yu Sun, Sin-Tian Wan, Sin-Syue Li, Ya-Ting Hsu, Kung-Chia Young. Plasma lipid profiling increased cardiometabolic risks in acute myeloid leukaemia patients pre- and postchemotherapy. J. Biomed. Lab. Sci. 2022;34(2).
  4. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Sterol O-acyltransferase 2 chaperoned by Apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses. Commun Biol. 2021;4(1):564.
  5. Li Y, Wang X, Han Y, Sun HY, Hilborn J, Shi L. Click chemistry-based biopolymeric hydrogels for regenerative medicine. Biomed Mater. 2021;16;16(2):022003.
  6. Pinals RL, Ledesma F, Yang D, Navarro N, Jeong S, Pak JE, Kuo L, Chuang YC, Cheng YW, Sun HY, Landry MP. Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors. Nano Lett. 2021;10;21(5):2272-2280.
  7. Tsai P, Lin TY, Cheng SL, Sun HY, Chen SF, Young KC. Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection. J Microbiol Immunol Infect. 2020;53(5):715-723.
  8. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chang HA, Chong LW, Chang HC, Young KC, Bai CH, Tsao CW. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation. Biomed Res Int. 2019; 3102414.
  9. Wang MY, Huang HY, Kuo YL, Lo C, Sun HY, Lyu YJ, Chen BR, Li JN, Chen PS. TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer. Cancers (Basel). 2019;11(2):210.
  10. Lai HH, Li CW, Hong CC, Sun HY, Chiu CF, Ou DL, Chen PS. TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Mol Oncol. 2019;13(4):928-945.
  11. Tsai P, Lin CC, Sun HY, Lee JC, Chang TT, Young KC. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia. J Microbiol Immunol Infect. 2018;51(4):446-455.
  12. Sun HY, Cheng PN, Tseng CY, Tsai WJ, Chiu YC, Young KC. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018;67(7):1342-1350.
  13. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chong LW, Chang HC, Bai CH, Young KC, Tsao CW. Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses. 2018;10(2):57.
  14. Sun HY, Lin CC, Tsai PJ, Tsai WJ, Lee JC, Tsao CW, Cheng PN, Wu IC, Chiu YC, Chang TT, Young KC. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cell Microbiol. 2017;19(4):e12673

專利

2021, 一種應用於抑制細胞內脂質積累的多肽及其合成方法，發明人: 孫宏羽(1)、秦儂(2)、莊詠鈞(3)、鄭又瑋(4) (Patent No. ZL 2021 1 0245720.4, 已授權).

研討會論文 (2017-2022)

  1. Sin-Tian Wang, Tzu-Ying Chen, Hung-Yu Sun*, Kung-Chia Young*.  Apolipoprotein J-chaperoned sterol O-acyltransferase 2 induces steatosis with hepatitis C virus infection. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  2. Sin-Tian Wang, Pin-Nan Cheng, I-Che Feng, Hung-Yu Sun*, Kung-Chia Young*. Post-therapeutic interdependence of long-term glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  3. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-mediated sterol O-acyltransferase activation facilitates hepatic lipid accumulation induced by hepatitis C virus infection. 27th International Symposium on Hepatitis C Virus and Related Viruses, Virtual meeting. 2021, Jul. 06-09. 
  4. Duan Shuangdi, Gao Yating, Pi Jiayi, Qin Nong, Sun Hung-Yu*. Apolipoprotein J induced hepatic lipid deposition via impairing lipophagy. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  5. Hung-Yu Sun*, Tzu-Ying Chen, Shuang-Di Duan, Nong Qin, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-chaperoned sterol O-acyltransferase 2 facilitates stress-induction of hepatic lipid accumulation. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  6. Hung-Yu Sun, Tzu-Ying Chen, Kung-Chia Young. The role of apolipoprotein J in HCV-dysregulated intracellular cholesterol homeostasis. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  7. Dyoness Charmaine Tan, Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. The roles of lipoprotein/apolipoprotein in HCV-induced lipid accumulation, cellular senescence and DNA repair. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  8. Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on the roles of lipoprotein/apolipoprotein in lipid accumulation, cellular senescence and DNA repair. International Symposiums on Immunity and Infection, Tainan, Taiwan (R.O.C), 2018, Oct. 19-20.
  9. Tzu-Ying Chen, Hung-Yu Sun, Yu-Ching Tan, Kung-Chia Young. Study on the role of apolipoprotein J in aberrant lipid accumulation with hepatitis C virus infection. 25th International Symposium on Hepatitis C Virus and Related Viruses, Dublin, Ireland, 2018, Oct. 08-11.
  10. Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on apolipoprotein J-mediated lipid accumulation in hepatocytes and macrophages. International Symposium on Major Southeast Asia Infectious Diseases, Taiwan-Japan Joint, Tainan, Taiwan (R.O.C), 2017, Nov. 11-12.

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