跳到主要內容區
  1. 首頁
  2. 成員介紹
  3. 專任教師
  4. 孫宏羽 助理教授

孫宏羽 助理教授

孫宏羽（Hung-Yu Sun）助理教授
10

學經歷：

中興大學 動物系 學士 1998-2002

成功大學 分子醫學研究所 碩士 2002-2004

成功大學 基礎醫學研究所 博士2004-2011

成功大學 博士後研究 2012-2018

渥太華大學 訪問學者 2016-2016

成功大學 分子醫學研究所 兼任助理教授 2018-2022

湖南大學 生物學院 教授 2018-2022

成功大學 生理學研究所 助理教授 2022-迄今

專長學科 ：

脂蛋白生理學；非酒精性脂肪肝；宿主代謝與病毒感染；病毒致病機轉

獎勵事項 ：

 

2023：112年臺灣綜合大學年輕學者創新研發成果選拔 「生醫領域」－傑出獎

2023：國立成功大學優質專利補助

2023：亞太肝臟研究協會年會-最佳口頭報告獎

2017：財團法人肝病防治學術基金會肝病防治優秀論文獎

2013：行政院國家科學委員會博士後研究人員學術著作獎

2012: 台灣微生物學會第二十屆第三次年會口頭發表論文獎（病毒學組）

2011：台灣微生物學會嚴智鍾教授獎學金

E-mail

hysun@gs.ncku.edu.tw

辦公室

   82-0716 分機：5457

實驗室

82-0557 分機：5320 

嗜好：慢跑、登山、旅遊、健身

研究方向及興趣(影音)：

1.探討載脂蛋白對代謝性疾病及病毒感染的影響

2.研究壓力誘導載脂蛋白J伴護蛋白對於脂肪代謝的影響

3.開發緩解細胞內脂肪異位沈積的多肽
實驗室網站：

實驗室成員：

現在成員

博士班：

碩士班：黃美齊、張雅雯、 柯詠瀚、許羽婷

大學生：邱繼嶢

助理：紀力齊、王欣慈 

畢業生

曾經指導學生

2021: 皮嘉一 (碩士)、高雅廷(碩士)

2022: 秦儂(碩士)、孫培(碩士)

2023: 段雙迪 (博士)

2024: 陳威佐(碩士)、王欣慈(碩士)

相關著作（PubMed連結）

研究論文(2017-2024)

  1. Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, Yating Gao, Lamei Liu, Zenghui Li, Ya Li, Liyang Shi, Qiang Gao, Ye Qiu, Songqing Tan, Chun-Hsiang Wang, Tzu-Ying Chen, Sin-Tian Wang, Kung-Chia Young, Hung-Yu Sun*. Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition. Hepatology, 2023; 78(4):1182-1199. 
  2. Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Sin-Tian Wang, Yen-Cheng Chiu, Hung-Chih Chiu, Shih-Chieh Chien, Kung-Chia Young. Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents. J Virus Erad. 2023;9(1):100318.
  3. Shuangdi Duan, Jiayi Pi, Chun-Hsiang Wang, Yi-Chou Hou, Chung-Ying Andy Lee, Cheng-Jui Lin, Liyang Shi, Kung-Chia Young, Hung-Yu Sun*. Assessment of ELISA-based method for the routine examination of serum indoxyl sulfate in patients with chronic kidney disease. Heliyon. 2022;8(12):e12220.
  4. Cong Wang, Xue Li, Changping Yu, Luoling Wang, Rilin Deng, Yan Xu, Renyun Tian, Shengwen Wen, Hui Liu, Zihao Chen, yingdan zhang, Hungyu Sun, Haizhen Zhu, Jianli Wang, Songqing Tang. RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth. Nature Communications. (Under review)
  5. Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Yen-Cheng Chiu, Sin-Tian Wang, Dyoness Charmaine Tan, Hung-Chih Chiu1, Shih-Chih Chien, Kung-Chia Young. Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. J Microbiol Immunol Infect. S1684-1182(22)00095-0 (Co-first author)
  6. Shu-Fang Hsieh, Hung-Yu Sun, Sin-Tian Wan, Sin-Syue Li, Ya-Ting Hsu, Kung-Chia Young. Plasma lipid profiling increased cardiometabolic risks in acute myeloid leukaemia patients pre- and postchemotherapy. J. Biomed. Lab. Sci. 2022;34(2).
  7. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Sterol O-acyltransferase 2 chaperoned by Apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses. Commun Biol. 2021;4(1):564.
  8. Li Y, Wang X, Han Y, Sun HY, Hilborn J, Shi L. Click chemistry-based biopolymeric hydrogels for regenerative medicine. Biomed Mater. 2021;16;16(2):022003.
  9. Pinals RL, Ledesma F, Yang D, Navarro N, Jeong S, Pak JE, Kuo L, Chuang YC, Cheng YW, Sun HY, Landry MP. Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors. Nano Lett. 2021;10;21(5):2272-2280.
  10. Tsai P, Lin TY, Cheng SL, Sun HY, Chen SF, Young KC. Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection. J Microbiol Immunol Infect. 2020;53(5):715-723.
  11. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chang HA, Chong LW, Chang HC, Young KC, Bai CH, Tsao CW. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation. Biomed Res Int. 2019; 3102414.
  12. Wang MY, Huang HY, Kuo YL, Lo C, Sun HY, Lyu YJ, Chen BR, Li JN, Chen PS. TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer. Cancers (Basel). 2019;11(2):210.
  13. Lai HH, Li CW, Hong CC, Sun HY, Chiu CF, Ou DL, Chen PS. TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Mol Oncol. 2019;13(4):928-945.
  14. Tsai P, Lin CC, Sun HY, Lee JC, Chang TT, Young KC. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia. J Microbiol Immunol Infect. 2018;51(4):446-455.
  15. Sun HY, Cheng PN, Tseng CY, Tsai WJ, Chiu YC, Young KC. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018;67(7):1342-1350.
  16. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chong LW, Chang HC, Bai CH, Young KC, Tsao CW. Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses. 2018;10(2):57.
  17. Sun HY, Lin CC, Tsai PJ, Tsai WJ, Lee JC, Tsao CW, Cheng PN, Wu IC, Chiu YC, Chang TT, Young KC. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cell Microbiol. 2017;19(4):e12673

專利

2024, OPTIMIZING LIPID AND GLYCEMIC HOMEOSTASIS THROUGH THERAPEUTIC PEPTIDE NAVIGATION, 發明人: 1.楊孔嘉；2.孫宏羽 美國(申請號 63/659,956)

2024, POLYPEPTIDE APPLIED TO INHIBITION OF INTRACELLULAR LIPID ACCUMULATION AND SYNTHESIS METHOD THEREOF，發明人: 孫宏羽(1)、秦儂(2)、莊詠鈞(3)、鄭又瑋(4)、段雙迪(5)、高雅廷(6)、楊孔嘉(7)，美國(申請號 18/576,106)

2024, MK52用於製備促進脂質分解作用及減緩相關症候群之醫藥組成物的用途,發明人: 孫宏羽(1)、楊孔嘉(2) (台灣發明專利申請號 112150571)

2023, 一種用於緩解代謝症候群發展的載脂蛋白J拮抗肽,發明人: 孫宏羽(1)、陳百昇(2)、楊孔嘉(3) (美國臨時案申請號：63/384,953)

2021, 一種應用於抑制細胞內脂質積累的多肽及其合成方法，發明人: 孫宏羽(1)、秦儂(2)、莊詠鈞(3)、鄭又瑋(4) (Patent No. ZL 2021 1 0245720.4, 已授權).

研討會論文 (2017-2022)

  1. Hsin-Tzu Wang, Mei-Ling Cheng, Chi-Jen Lo, Hung-Yu Sun*. Reactivation of bile acid alternative pathway rebalances cholesterol homeostasis and relieves metabolic-associated fatty liver disease. APASL Single Topic Conference on Metabolic Associated Fatty Liver Disease (MAFLD), Kaohsiung, Taiwan, 2024, Jun. 28-30
  2. Hung-Yu Sun*. Apolipoprotein J facilitates diabetic nephropathy progression via mTOR-TFEB-autophagy axis. The 33rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2024), Kyoto, Japan, 2024, Mar. 27-31. (Oral presentation)
  3. Wei-Zuo Chen, Hung-Yu Sun*. Investigating the Interactome of Apolipoprotein J under Lipid Stress. The 33rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2024), Kyoto, Japan, 2024, Mar. 27-31. (Corresponding author)
  4. Hsin-Tzu Wang, Hung-Yu Sun*. Targeting Apolipoprotein J restores hepatic cholesterol balance via bile acid alternative pathway. The 33rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2024), Kyoto, Japan, 2024, Mar. 27-31. (Corresponding author)
  5. Shuang-di Duan, Hung-Yu Sun*. Apolipoprotein J Accumulation in Renal Tubules Contributes to Pathogenesis of Diabetic Nephropathy. 10th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2023). Daegu, Korea, 2023, Nov. 1-4. (Samyang Best Research Award)
  6. Jiayi Pi, Hung-Yu Sun*. Apolipoprotein J facilitates indoxyl sulfate-induced activation of AhR and promotes the progression of chronic kidney disease. 10th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2023). Daegu, Korea, 2023, Nov. 1-4.
  7. Mei-Chi Huang, Jia-Yi Pi, Hung-Yu Sun*. Apolipoprotein J facilitates indoxyl sulfate-mediated impairment of mitophagy in renal epithelial cell. Taiwan Society for Mitochondrial Research and Medicine: DiscoverMITO in Human Diseases. Tainan, Taiwan, 2023, Oct. 28
  8. Shuang-di Duan, Nong Qin, Jia-I Pi, Pei Sun, Hsin-Tzu Wang, Hung-Yu Sun*. Hepatic Apolipoprotein J facilitates metabolic disease progression by promoting mTOR-mediated suppression of autophagy. EASL Congress 2023, Vienna, Austria, 2023, Jun. 21-24. (Registration bursary Awards)
  9. Hsin-Tzu Wang, Shuang-di Duan, Nong Qin, Jia-I Pi, Pei Sun, Hung-Yu Sun*. Targeting Apolipoprotein J restores autophagy and improves metabolic-associated fatty liver disease and diabetic nephropathy. EASL Congress 2023, Vienna, Austria, 2023, Jun. 21-24. (Full Bursary Awards)
  10. Hung-Yu Sun*, Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, Hsin-Tzu Wang. Targeting Apolipoprotein J chaperone activity relieves hepatic steatosis through facilitating proteasomal degradation of mTOR. The 32nd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2023), Taipei, Taiwan, 2023, Feb. 15-19. (Corresponding author) (Best oral presentation award)
  11. Yi-Chou Hou, Hung-Yu Sun*. Identification of ELISA-based methods for the routine examination of serum indoxyl sulfate levels in CKD patients. 2022 Annual Meeting of Taiwan Society of Nephrology, Taipei, Taiwan, 2022, Dec. 10-11. (Corresponding author)
  12. Hung-Yu Sun*, Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun. Apolipoprotein J chaperones mTOR to suppress lipophagy and facilitate hepatic lipid deposition. 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology. Taipei, Taiwan, 2022, Nov. 07-11. (Short talk) (Corresponding author)
  13. Sin-Tian Wang, Tzu-Ying Chen, Hung-Yu Sun*, Kung-Chia Young*.  Apolipoprotein J-chaperoned sterol O-acyltransferase 2 induces steatosis with hepatitis C virus infection. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  14. Sin-Tian Wang, Pin-Nan Cheng, I-Che Feng, Hung-Yu Sun*, Kung-Chia Young*. Post-therapeutic interdependence of long-term glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  15. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-mediated sterol O-acyltransferase activation facilitates hepatic lipid accumulation induced by hepatitis C virus infection. 27th International Symposium on Hepatitis C Virus and Related Viruses, Virtual meeting. 2021, Jul. 06-09. 
  16. Duan Shuangdi, Gao Yating, Pi Jiayi, Qin Nong, Sun Hung-Yu*. Apolipoprotein J induced hepatic lipid deposition via impairing lipophagy. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  17. Hung-Yu Sun*, Tzu-Ying Chen, Shuang-Di Duan, Nong Qin, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-chaperoned sterol O-acyltransferase 2 facilitates stress-induction of hepatic lipid accumulation. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  18. Hung-Yu Sun, Tzu-Ying Chen, Kung-Chia Young. The role of apolipoprotein J in HCV-dysregulated intracellular cholesterol homeostasis. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  19. Dyoness Charmaine Tan, Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. The roles of lipoprotein/apolipoprotein in HCV-induced lipid accumulation, cellular senescence and DNA repair. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  20. Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on the roles of lipoprotein/apolipoprotein in lipid accumulation, cellular senescence and DNA repair. International Symposiums on Immunity and Infection, Tainan, Taiwan (R.O.C), 2018, Oct. 19-20.
  21. Tzu-Ying Chen, Hung-Yu Sun, Yu-Ching Tan, Kung-Chia Young. Study on the role of apolipoprotein J in aberrant lipid accumulation with hepatitis C virus infection. 25th International Symposium on Hepatitis C Virus and Related Viruses, Dublin, Ireland, 2018, Oct. 08-11.
  22. Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on apolipoprotein J-mediated lipid accumulation in hepatocytes and macrophages. International Symposium on Major Southeast Asia Infectious Diseases, Taiwan-Japan Joint, Tainan, Taiwan (R.O.C), 2017, Nov. 11-12.

實驗室特色連結

實驗室活動照片連結