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薛元毓 副教授

薛元毓（Yuan-Yu Hsueh）副教授

 1

學經歷：

學歷:

國立成功大學 臨床醫學研究所 博士 2011-2015

國立成功大學 臨床醫學研究所 碩士 2007-2010

國立成功大學 醫學系 學士 1996-2003

經歷:

成大醫院整形外科   主治醫師   2009-迄今

成大醫學系外科學科 臨床副教授 2021-2024

美國加州大學洛杉磯分校(UCLA)

生物工程學系訪問學者 2017-2019

東京大學附設醫院 形成外科(整形外科)研究員 2014 

成大醫學系外科學科 臨床助理教授 2015-2021

成大醫院整形外科 住院醫師 2003-2009

專長學科 ：

一、研究專長

(1) 再生醫學：周邊神經再生、電刺激、神經調控、傷口癒合及組織再生、皮瓣血管新生

(2) 疤痕研究：蟹足腫及肥厚性疤痕致病機轉及治療 

(3) 幹細胞研究：脂肪幹細胞、神經幹細胞、血管幹細胞

(4) 醫材開發：神經電刺激、止痛裝置、AI軟體

二、臨床專長

(1) 手外科：手部創傷、斷指再接、周邊神經手術、肌腱手術、神經電刺激

(2) 疤痕整形：蟹足腫及肥厚性疤痕治療、修疤手術、疤痕平整修復

(3) 身體雕塑整形：抽脂手術、自體脂肪移植

(4) 細胞治療：自體脂肪幹細胞再生治療(特管法規範)

獎勵事項 ：

  • 2024台灣國際傑出發明家獎 學術國光獎章 (2024/10)
  • 2024國家新創精進獎  技術持續精進獎 (2024/10)
  • 2023國家新創精進獎  技術持續精進獎 (2023/11)
  • 第二十屆國家新創獎 學研新創獎 (2023/10)
  • 2023臺灣綜合大學系統年輕學者創新研發成果 生醫領域優等獎(2023/10)
  • 2023未來科技獎  生技新藥與醫材領域 (2023/08)
  • 第二十三屆旺宏金矽獎 半導體設計與應用大賽-最佳創意指導教授 (2023/07)
  • 第二十三屆旺宏金矽獎 應用組-最佳指導教授獎 (2023/07)
  • 第十九屆國家新創獎 學研新創獎 (2022/08)
  • 成大醫院2021年高影響力期刊獎（2022/02）
  • 成杏醫學基金會2021年度優良論文獎（2021/12）
  • 國立成功大學醫學院2014年度最佳青年研究員獎 （2016/04）
  • 中華民國斐陶斐學術榮譽學會榮譽會員（2015/06）
  • 2014 國立成功大學醫院醫學研究海報競賽：優秀獎 （2014/12）
  • 國立成功大學醫學院博士生論文比賽：傑出研究獎 （2014/06）
  • 臺灣再生醫學會口頭論文比賽：第一名（2014/02）
  • TIGP-NCKU 神經科學研討會出國競賽：第二名 （2014/01）
  • 臺灣再生醫學協會口頭論文比賽：特優獎 （2012/02）
  • 2010 國立成功大學醫院醫學研究海報競賽：第三名 （2010/12）

E-mail

yyhsueh@mail.ncku.edu.tw

辦公室

82-0719 分機：5460

實驗室

82-0754 分機：5447

嗜好：旅遊、露營、閱讀

研究方向及興趣：

(1) 再生醫學：周邊神經再生、電刺激、神經調控、傷口癒合及組織再生、皮瓣血管新生

(2) 疤痕研究：蟹足腫及肥厚性疤痕致病機轉及治療 

(3) 幹細胞研究：脂肪幹細胞、神經幹細胞、血管幹細胞

(4) 醫材開發：神經電刺激、止痛裝置、AI軟體

實驗室網站:https://nckunmr.wordpress.com 
實驗室成員：

現在成員

整形外科主治醫師/助理教授/博士: 陳思翰

博士後研究員: 黃順和

整形外科主治醫師/助理教授/碩士: 洪國書

整形外科主治醫師/碩士: 曾婉玲

整形外科主治醫師/博士生: 鍾子駿

整形外科住院醫師/博士生: 辛怡萱

整形外科住院醫師: 許洺維、林昱文

成大PGY醫師: 張乃云

成大醫學系大學生: 林淳蔚、謝松均、歐柏良

研究助理: 林貞杏、邱莉喻、李念潔

臨床研究護理師: 歐玉婷

相關著作（PubMed連結）
  1. Yi-Syuan Shin#, Kuo-Shu Hung, Chung-Te Tsai, Meng-Hsuan Wu, Chih-Lung Lin, Yuan-Yu Hsueh*. Validation of multispectral imaging-based tissue oxygen saturation detecting system for wound healing recognition on open wounds. Journal of Biomedical Optics, 2024 Aug 29(8):086004-1~13
  2. Szu-Han Chen#, Yu-Wen Lin#, Wan-Ling Tseng, Wei-Tso Lin, Sheng-Che Lin, Yuan-Yu Hsueh*. Ultrahigh frequency transcutaneous electrical nerve stimulation for neuropathic pain alleviation and neuromodulation. Neurotherapeutics 2024 Feb 16;21(3):e00336. doi: 10.1016/j.neurot.2024.e00336.
  3. Jyun-Yuan Huang, Tzyy-Yue Wong, Ting-Yuan Tu, Ming-Jer Tang, Hsi-Hui Lin, Yuan-Yu Hsueh*. Assessment of Tilapia Skin Collagen for Biomedical Research Applications in Comparison with Mammalian Collagen. Molecules. 2024 Jan 13;29(2):402.
  4. Chia-Bao Chu, Chao-Chun Yang, Yuan-Yu Hsueh, Po-Chuan Chen, Yi-Kai Hong, Yu-Yun Kuo, Shaw-Jenq Tsai. Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa. Br J Dermatol. 2023Aug 4;ljad273. doi: 10.1093/bjd/ljad273IF: 11.0 Q1
  5. Szu-Han Chen#, Chia-Ching Wu, Wan-Ling Tseng, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Sheng-Che Lin , Yuan-Yu Hsueh*. Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve. Front Neurosci. 2023 Jun 29;17:1172740
  6. Ming-Wei Hsu#, Szu-Han Chen, Wan-Ling Tseng, Kuo-Shu Hung, Tzu-Chun Chung, Sheng-Che Lin, Jahyun Koo and Yuan-Yu Hsueh*. Physical processing for decellularized nerve xenograft in peripheral nerve regeneration. Front. Bioeng. Biotechnol. 2023 May 30; 11:1217067. doi: 10.3389/fbioe.2023.1217067
  7. Meng-Wei Lin, Yu-Tzu Chang, Yuan-Yu Hsueh*, Hyperosmolar Hyperglycemic Crisis   After Burn Injury in a Patient With Advanced Amyotrophic Lateral Sclerosis: A  Case Report. Annals of Plastic Surgery 2022 Oct 1;89(4):373-375
  8. Woo-Youl Maeng, Wan-Ling Tseng#, Song Li, Jahyun Koo, Yuan-Yu Hsueh*. Electroceuticals for peripheral nerve regeneration. Biofabrication 2022 Sep;14(4): 042002-042021
  9. Anjali Yadav, Thamil Selvee Ramasamy, Sheng-Che Lin, Szu-Han Chen, Jean Lu, Ya-Hsin Liu, Fu-I Lu, Yuan-Yu Hsueh, Shau-Ping Lin, Chia-Ching Wu. Autologous Platelet-Rich Growth Factor Reduces M1 Macrophages and Modulates Inflammatory Microenvironments to Promote Sciatic Nerve Regeneration Biomedicines. 2022 Aug 17;10(8):1991.
  10. Wei-Yu Tsai, Yuan-Yu Hsueh, Pei-Yu Chen, Kuo-Shu Hung, Chih-Chung Huang. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jun;69(6):1871-1880
  11. LeeAnn K. Li, Wen‑Chin Huang, Yuan‑Yu Hsueh, Ken Yamauchi, Natalie Olivares, Raul Davila, Jun Fang, Xili Ding, Weikang Zhao, Jennifer Soto, Mahdi Hasani, Bennett Novitch and Song Li. Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury. Stem Cell Research & Therapy 2022 May 16;13(1):205-218.
  12. Anjali Yadav, Tzu-Chieh Huang, Szu-Han Chen, Thamil Selvee Ramasamy, Yuan-Yu Hsueh, Shau-Ping Lin , Fu-I Lu, Ya-Hsin Liu, Chia-Ching Wu. Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination. Journal of Neuroinflammation 2021; 18(1):238-253.
  13. An Huang, Yi-Shiuan Lin, Ling-Zhen Kao, Yu-Wei Chiou, Gang-Hui Lee, Hsi-Hui Lin, Chih-Hsing Wu, Chin-Sung Chang, Kuo-Ting Lee, Yuan-Yu Hsueh, Pei-Jane Tsai, Ming-Jer Tang, Yau-Sheng Tsai. Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity. Clinical Translational Medicine. 2021 Sep;11(9):e543. doi: 10.1002/ctm2.543IF: 7.9 Q1
  14. Szu-Han Chen#, Chia-Ching Wu, Sheng-Che Lin, Wan-Ling Tseng, Tzu-Chieh Huang, Anjali Yadav, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Yuan-Yu Hsueh* Investigation of neuropathology after nerve release in chronic constriction injury of rat sciatic nerve. International Journal of Molecular Sciences 2021; 22(9):4746-4763
  15. Yeu-Her Lai, Li-Wen Chen, Yuan-Yu Hsueh* Delayed neurological sequelae in an infant after carbon monoxide intoxication. Journal of Burn Care and Research 2021 Apr 23:irab074. doi: 10.1093/jbcr/irab074IF: 1.5 Q3
  16. Jun Fang, Junren Sia, Jennifer Soto, Pingping Wang, LeeAnn K Li, Yuan-Yu Hsueh, Raymond Sun, Kym Francis Faull, James G Tidball, Song Li, Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nature Biomedical Engineering 2021 Aug;5(8):864-879; doi: 10.1038/s41551-021-00696-y
  17. Yeon Sik Choi, Yuan-Yu Hsueh, Jahyun Koo, Quansan Yang, Buwei Hu, Zhaoqian Xie, Raudel Avila, Geumbee Lee, Ning Zheng, Claire Liu, Yameng Xu, Young Joong Lee, Weikan Zhao, Jun Fang, Yujun Deng, Seung Min Lee, Iwona Stepien, Ying Yan, Joseph Song, Chad Haney, Yong Suk Oh, Wentai Liu, Hong-Joon Yoon, Anthony Banks, Matthew MacEwan, Guillermo Ameer, Wilson Ray, Yonggang Huang ,Colin Franz, Tao Xie, Song Li, Abraham Vazquez-Guardado, John A. Rogers. Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration. Nature Communications 2020 Nov; 11(1):5990-6003
  18. Chen SH, Huang TC, Wang JY, Wu CC, Hsueh YY*. Controllable forces for reproducible chronic constriction injury mimicking compressive neuropathy in rat sciatic nerve. J Neurosci Methods. 2020 Apr; 335:108615.
  19. Huang CW, Lu SY, Huang TC, Huang BM, Sun HS, Yang SH, Chuang JI, Hsueh YY, Wu YT, Wu CC. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics. 2020 Feb; 10(6):2817-2831.
  20. Fang J, Hsueh YY, Soto J, Sun W, Wang J, Gu Z, Khademhosseini A, Li S. Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming. ACS Nano. 2020 Feb; 14(2):1296-1318.
  21. Huang CW, Hsueh YY, Huang WC, Patel S, Li S. Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. Stem Cell Res Ther. 2019 Aug; 10(1):234.
  22. Chang TY, Hsueh YY, Yen YT, Lee JW. Factors affecting functional outcomes following mangled lower limb injury. Asian J Surg. 2019 May.; 42(5):644-646.
  23. Lin CH, Chiu PY, Hsueh YY, Shieh SJ, Wu CC, Wong TW, Chuong CM, Hughes MW.  Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing. Exp Dermatol. 2019 Apr.; 28(4):472-479.
  24. Hsueh WT, Hung KS, Chen YC, Huang YT, Hsu CK, Ogawa R, Hsueh YY*.  Adjuvant Radiotherapy After Keloid Excision: Preliminary Experience in Taiwan.  Ann Plast Surg. 2019 Jan.; 82(1S Suppl 1):S39-S44.
  25. Chang TY, Lee YC, Lin YC, Wong ST, Hsueh YY, Kuo YL, Shieh SJ, Lee JW. Implantable Doppler Probes for Postoperatively Monitoring Free Flaps: Efficacy. A Systematic Review and Meta-analysis. Plast Reconstr Surg Glob Open. 2016 Nov; 4(11):e1099
  26. Huang CF, Chang YJ, Hsueh YY, Huang CW, Wang DH, Huang TC, Wu YT, Su FC, Hughes M, Chuong CM, Wu CC. Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction. Sci Rep. 2016 May; 6:26436.
  27. Hsueh YY#, Wang DH, Huang TC, Chang YJ, Shao WC, Tuan TL, Hughes MW, Wu CC. Novel skin chamber for rat ischemic flap studies in regenerative wound repair. Stem Cell Res Ther. 2016 May; 7(1):72.
  28. Chang YJ, Huang HC, Hsueh YY, Wang SW, Su FC, Chang CH, Tang MJ, Li YS, Wang SH, Shung KK, Chien S, Wu CC. Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention. Sci Rep. 2016 Feb; 6:22147.
  29. Huang CW, Huang CC, Chen YL, Fan SC, Hsueh YY, Ho CJ, Wu CC. Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling.  Biomed Res Int. 2015 Oct.; 862485.
  30. Hsueh YY#, Chang YJ, Huang CW, Handayani F, Chiang YL, Fan SC, Ho CJ, Kuo YM, Yang SH, Chen YL, Lin SC, Huang CC, Wu CC. Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury. Sci Rep. 2015 Oct; 5:14985.
  31. Chang TY, Pan SC, Huang YH, Hsueh YY *. Blindness after calcium hydroxylapatite injection at nose. J Plast Reconstr Aesthet Surg. 2014 Dec; 67(12):1755-7.
  32. Hsueh YY#, Chang YJ, Huang TC, Fan SC, Wang DH, Chen JJ, Wu CC, Lin SC. Functional recoveries of sciatic nerve regeneration by combining chitosan coated conduit and neurosphere cells induced from adipose-derived stem cells. Biomaterials. 2014 Feb; 35(7):2234-44.
  33. Chen WC, Hsueh YY *. Primary dermal melanoma in a 19-year-old asian man. Dermatol Surg.2013 Apr; 39(4):662-5.
  34. Hsueh YY#, Chiang YL, Wu CC, Lin SC. Spheroid formation and neural induction in human adipose-dervived stem cells on a chitosan-coated surface. Cells Tissues Organs,2012; 196(2):117-128.
  35. Hsueh YY#, Chen CL, Pan SC. Analysis of factors influencing limb amputation in high-voltage electrically injured patients. Burns. 2011; 37(4):673-677.
  36. Hsueh YY#, Shieh SJ, Chiu HY. Revascularization and dynamic distraction for a complex finger injury. J Hand Surg Eur Vol. 2010 Nov; 35(9):762-4.
  37. Lee JW, Hsueh YY, Lee JS. Composite skull and dura defect reconstruction using combined latissimus dorsi musculocutaneous and serratus anterior muscle-rib free flap coupled with vascularized galea transfer:  a case report. Microsurgery. 2010 Nov; 30(8):632-5.
  38. Hsueh YY#, Shieh SJ. Two-stage retroauricular flap to reconstruct a helical rim defect. Dermatol Surg. 2009 Nov; 35(11):1827-30.

實驗室活動照片連結