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Shaw-Jenq (Sean) Tsai

Shaw-Jenq Sean Tsai, Chair Professor

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Education and Career Experience:

B.S. National Cheng-Kung University, 1982-1986

M.S. Eastern Michigan University, 1990-1992

Ph.D. University of Wisconsin-Madison, 1993-1997

Joined Cheng Kung University Faculty, 1998

Assistant Professor，1998-2002

Associate Professor，2002-2005

Professor，2005-2008

Distinguished Professor，2008-2019

Chair Professor，2019-

Visiting Professor, Baylor College of Medicine (2010-2011)

Director General, Ministry of Science and Technology (2014-2017)

Ambassador, World Endometriosis Society (2014- )

President, Chinese Physiological Society (2016- 2020 )

President, Asian Society for Endometriosis and Adenomyosis (2019- 2020)

Councilor, Society for Experimental Biology and Medicine (2018- )

Global editor (Asian office), Experimental Biology & Medicine (2012- )

Senior editor, Journal of Molecular Endocrinology (2020- )

Senior editor, Journal of Endocrinology (2020- )

Speciality:

Translational Medicine, Bioinformatics,Cancer Biology, Endometriosis

Award:

1. National Science Council: Distinguished Research Award (2011)

2. Society for Experimental Biology and Medicine: Distinguished Scientist Award (2014)

3. Ministry of Science and Technology: Distinguished Research Award (2018)

4. Society for Experimental Biology and Medicine: Fellow (2018)

5. American Association for Cancer Research: Most-Cited Article Published in 2017 Cancer Research (2019)

6. Society for the Study of Reproduction: Fuller W. Bazer SSR International Scientist Award (2021)

7. Ministry of Education: The 65th Academic Award (2022)

8. International Union of Physiological Sciences: Academy Fellow 2022

E-mail

seantsai@mail.ncku.edu.tw

Office

82-0701 Basic Medical Science Building (TEL: +886-6-2353535#5426)

Laboratory

82-0734 Basic Medical Science Building (TEL: #5429)

Hobbies: Enjoy Science and Life

Research interests (Movie)：

My research interests focus on understanding the molecular mechanisms of human diseases. Our studies could be divided into two areas:
1. Endometriosis: Endometriosis is a common gynecological disease with the prevalence of 10-15%. It is a complex disease with unknown etiology and severely reduces life quality of affected women and their family. We focus on local and epigenetic factors that cause inflammation in the peritoneal cavity, aberrant production of steroid hormones, angiogenesis, and suppression of immune function. Recent focus is on delineating pathophysiological mechaisms of deep infiltrating endometriosis (DIE).
2. Cancer: Drug resistance is the most critical issue that contributes to treatment failure and mortality. Hypoxia is one of the most critical factors contributing to drug resistance. However, mechanisms responsible for hypoxia-mediated increased in drug resistance remain largely unknown. We have employed systems biology approach to investigate effects of hypoxia-mediated gene regulatory networks in drug resistance and cancer malignancy. Pancreatic adenocarcinoma and colon cancer are two major cancers we focus on.

People:

Current member
Research Assistants：Mei-Feng Huang、Yen-Yu Lai、Yi-Shan Ya、Yi-Cheng Tang、Yi-Zhou Chung

Postdoctoral Fellows: Li-Yun Ding

Ph.D students: Huan-Tzu Hou、Jhao-Ling Fu、Hsiao-chien (Lauren) Tang、Chia-Bao Chu 、Cheng-Lin Wu

Master students: Ting-I (Debby) Lee、Yi-Chen Chen 、Kai-Jin Hsiao

Alumni 

Meng-Hsing Wu (Professor, Department of Obstetrics & Gynecology, National Cheng Kung University)

Hsien-An Pan (Superintendent, An-An Hospital)

Pei-Ling Hsu (Assistant Professor, Kaohsiung Medical University)、

Chu-An Wang (Assistant Professor, National Cheng Kung University)

Kuei-Yang Hsiao (Assistant Professor, National Chung Hsing University)

Shih-Chieh Ling (Associate Professor, National Cheng Kung University)

Ko-Fan Chen (Lecturer, University of Leicester, UK)

Ming-Chih Lai (Associate Professor, Chang Gung Memorial University)

Pei-Chin Chuang (Investigator, Kaohsiung Chang Gung Memorial Hospital)

Hsiu-Mei Chen (Postdoctoral fellow, NCKU hospital)

Chun-Wen Lu (Postdoctoral Fellow, Kaohsiung Chang Gung Memorial Hospital)

Pei-Chi Hou (Research Scientist, University of Virginia, USA)

Chih-Chao Hsu (Scientist, Roche Pharma, USA)

Hsiu-Chi Lee (Field Specialist, Roche Pharma)

Yo-Hua Lee (Freelancer, Stock market)

Wan-Ning Li (Postdoctoral Fellow, National Cancer Institute, USA)

Chin-Chung Lin (Reseach Scientist, Western Virginia University, USA)

Master students: Chieh-Ting Fan、Chien-Ju Tsai、Yu-Ju Li、Zou-Chi Huang

Selected Publications（PubMed Link）

  1. HT Hou, TC Lin, MH Wu, SJ Tsai* Feel so bac: is Fusobacterium the suspect causing endometriosis? Trends Mol Med. 18 Aug, 2023.  https://doi.org/10.1016/j.molmed.2023.08.003.
  2. T Harada, F Taniguchi, SW Guo, YM Choi, KO Biberoglu, SJ Tsai, S Alborzi , M Al-Jefout, A Chalermchokcharoenkit, A Sison-Aguilar, YF Fong, H Senanayake, A Popov, A Hestiantoro, Y Kaufmann The Asian society of endometriosis and adenomyosis (ASEA) guidelines for managing adenomyosis. Reprod Med Biol (Accepted) 2023.
  3. CB Chu, CC Yang, YY Hsueh, PC Chen, YK Hong, YY Kuo, S-J Tsai* Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa. Br J Dermatol (accepted) 2023. DOI: 10.1093/bjd/ljad273. 
  4. SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu*, SJ Tsai* Targeting YAP1 ameliorates progesterone resistance in endometriosis. Hum Reprod 38 (6), 1124-1134, 1 June 2023. DOI: 10.1093/humrep/dead071.
  5. PL Hsu, CW Chien, YA Tang, BW Lin, SC Lin, YS Lin, SY Chen, HS Sun*, SJ Tsai* Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv 9(15): eade3422, 12 Apr 2023. DOI: 10.1126/sciadv.ade3422.
  6. YS Lai CC Chang YY Chen TMH Nguyen J Xu YC Chen YF Chang CY Wang PS Chen SC Lin IC Peng SJ Tsai WT Chiu* Optogenetically engineered Ca2+ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death. J Cell Sci May 26, 2023. DOI: doi.org/10.1242/jcs.260819.
  7. YY Chao, BM Huang, IC Peng, PR Lee, YS Lai, WT Chiu, YS Lin, SH Lin, JH Chang, PS Chen, SJ Tsai*, CY Wang* ATM-ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. J Cell Physiol, 237(12):4487–4503, 2022.
  8. C.B. Chu, C.C. Yang, S.J. Tsai* Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chin J Physiol 64(6):257-265, Nov-Dec 2021, doi: 10.4103/cjp.cjp_67_21.
  9. C.B. Chu, C.C. Yang*, W.L. Li., S.H. Lin, C.K. Hsu, S.J. Tsai* The influence of gender and smoking on hidradenitis suppurativa -A retrospective study of 161 patients in Taiwan. Dermatologica Sinica 39:125-31,  July 2021
  10. C.B. Chu, C.C. Yang, S.J. Tsai* Global data analysis supports smoking as the fundamental element associated with geographic gender disparities in hidradenitis suppurativa. Br J Dermatol 185(5):1054-1056, June 2021 https://doi.org/10.1111/bjd.20581.
  11. CA Wang, CF Li, RC Huang, PC Hou, JP Liou, SJ Tsai* Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1/2 inhibitor. Mol Cancer Ther 20(9):1550-1560; doi: 10.1158/1535-7163.MCT-20-0963, 2021.
  12. CA Wang, and SJ Tsai* Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis. Exp Biol Med (Maywood), 246(19):2048-2056, June 2021
  13. PH Yu, PY Chou, WN Li, SJ Tsai, MH Wu* The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. Taiwan J Obstet Gynecol 60(4):711-717, 2021 Jul
  14. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* FGF9 induces neurite outgrowth upon ERK signaling in knock-in striatal Huntington's disease cells., Life Sci 267, 118952, 2021 Feb 15.
  15. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* Fibroblast growth factor 9 stimulates neuronal length through NF-kB signaling in striatal cell Huntington’s disease models. Mol Neurobiol 58 (5): 2396-2406, May 2021.
  16. WN Li, MH Wu, SJ Tsai* HYPOXIA AND REPRODUCTIVE HEALTH: The role of hypoxia in the development and progression of endometriosis. Reproduction 161 (1): F19-F31, 2021. doi: 10.1530/REP-20-0267
  17. HC Lee, SC Lin, MH Wu, SJ Tsai* Inhibiting NTRK2 signaling causes endometriotic lesion regression. Reproduction 161(1):11-19, 2021 Jan; doi: 10.1530/REP-20-0163.
  18. YS Lai, YH Chang, YY Chen, J Xu, CS Yu, SJ Chang, PS Chen, SJ Tsai, WT Chiu* Ca2+-regulated cell migration revealed by optogenetically engineered Ca2+ oscillations. J Cell Physiol 2020 Nov 26. doi: 10.1002/jcp.30190
  19. YH Li, TM Chen, BM Huang, SH Yang, CC Wu, YM Lin, JI Chuang, SJ Tsai, HS Sun FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture. Biol Reprod 103 (6):1300-1313, Dec 1, 2020
  20. WN Li, KY Hsiao, CA Wang, N Chang, PL Hsu, CH Sun, SR Wu, MH Wu*, SJ Tsai* Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis. Proc Natl Acad Sci U S A, 117 (41): 25859-25868, Oct. 13, 2020. doi.org/10.1073/pnas.1920037117
  21. PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng, CY Wang, SJ Tsai* Pathophysiological implications of hypoxia in human diseases. J Biomed Sci 27: 63, 2020 May 11. doi.org/10.1186/s12929-020-00658-7
  22. S Koks*, RW Williams, J Quinn, F Farzaneh, N Conran, SJ Tsai, G Awandare, SR Goodman COVID-19: Time for precision epidemiology. Exp Biol Med (Maywood). 245 677-679. Apr 2020, DOI: 10.1177/1535370220919349
  23. CA Wang, YH Chang, PC Hou, YJ Tai, WN Li, PL Hsu, SR Wu, CF Li, YS Shan, SJ Tsai* DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles 9 (1): 1746529, 2020 April 4. DOI: 10.1080/20013078.2020.1746529
  24. PS Chen, SC Lin, SJ Tsai* Complexity in regulating microRNA biogenesis in cancer. Exp Biol Med 245:395-401, 2020 March DOI: 10.1177/1535370220907314
  25. CH Lai, RY Chen, HP Hsieh, SJ Tsai, KC Chang, CJ Yen, YC Huang, YW Liu, JC Lee, YC Lai, LY Hung, BW Lin A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis. Cancer Lett 472:97-107, 2020 Mar 1; doi: 10.1016/j.canlet.2019.12.031.
  26. HC Lee, SC Lin, MH Wu*, SJ Tsai* Induction of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci 26 (6):734-744. doi: 10.1177/193371911878951, Jun; 2019.
  27. Wu, M.H., Hsiao, K.Y., and *Tsai, S. J. (2019) Hypoxia: The force of endometriosis. J Obstet Gynaecol Res 45, (3), pp. 532-541 PMID: 30618168
  28. Lin, S.C., Lee, H.C., Hsu, C.T., Huang, Y.H., Li, W.N., Hsu, P.L., Wu, M.H., and *Tsai, S.J. (2019) Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression, Theranostics 9, (3) 620-632 PMID: 30809297
  29. Hsu, P.L., Jou, J., and *Tsai, S.J.: ‘TYRO3: A potential therapeutic target in cancer’, Exp Biol Med (Maywood), 2019, 244, (2), pp. 83-99 PMID:30714403
  30. Chen, T.M., Lai, M.C., Li, Y.H., Chan, Y.L., Wu, C.H., Wang, Y.M., Chien, C.W., Huang, S.Y., Sun, H.S., and *Tsai, S.J.: ‘hnRNPM induces translation switch under hypoxia to promote colon cancer development’, EBioMedicine, 2019 PMID: 30852162
  31. Chen, T.M., Chen, Y.H., Sun, H.S., and *Tsai, S.J.Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis, Chin J Physiol, 2019 62 (1) DOI: 10.4103/CJP.CJP_11_19
  32. Fu, J.L., Hsiao, K.Y., Lee, H.C., Li, W.N., Chang, N., Wu, M.H., and *Tsai, S.J.: ‘Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis’, Hum Reprod, 2018, 33, (8), pp. 1517-1527 PMID: 29982401
  33. Li, W.N., Wu, M.H., and *Tsai, S.J.Critical Factors Involved in Chronic Inflammation in the Pathophysiology of Endometriosis. Adaptive Med, 2018 10(1): 1-9, DOI: 10.4247/AM.2018.ABI197
  34. Brown, D.M., Lee, H.C., Liu, S., Quick, C.M., Fernandes, L.M., Simmen, F.A., Tsai, S.J., and Simmen, R.C.M.: ‘Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis’, J Endocr Soc, 2018, 2, (7), pp. 765-778 PMID: 30151432
  35. Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S., and *Tsai, S. J.(2017) Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer Res, 77, 4305-4316 PMID: 28652251
  36. Lin, S. C., Lee, H. C., Hou, P. C., Fu, J. L., Wu, M. H., and *Tsai, S. J.(2017) Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility. J Pathol, 242, 476-487 PMID: 28608501
  37. Hsiao, K. Y., Lin, Y. C., Gupta, S. K., Chang, N., Yen, L., Sun, H. S., and *Tsai, S. J.(2017) Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer Res, 77, 2339-2350 PMID: 28249903
  38. Lin, S. C., Hsiao, K. Y., Chang, N., Hou, P. C., and *Tsai, S. J.(2017) Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. J Pathol, 241, 638-648 PMID: 28026024
  39. Lin, S. C., Kao, C. Y., Lee, H. J., Creighton, C. J., Ittmann, M. M., Tsai, S. J., Tsai, S. Y., and Tsai, M. J. (2016) Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun 7, 11418 PMID: 27108958
  40. Lai, M. S., Wang, C. Y., Yang, S. H., Wu, C. C., Sun, H. S., Tsai, S. J., Chuang, J. I., Chen, Y. C., and Huang, B. M. (2016) The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis,12, 61-77 PMID: 27078042
  41. Chien, C. W., Hou, P. C., Wu, H. C., Chang, Y. L., Lin, S. C., Lin, S. C., Lin, B. W., Lee, J. C., Chang, Y. J., Sun, H. S., and ＊ Tsai, S. J. (2016) Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene, 35, 5872-81, PMID: 27132510
  42. Wang, C. A., and ＊ Tsai, S. J. (2015) The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood), 240, 718-724 PMID: 25888649
  43. Liang, K. C., Tseng, J. T., Tsai, S. J., and Sun, H. S. (2015) Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem, 57, 29-38 PMID: 25748288
  44. Hsiao, K. Y., Wu, M. H., Chang, N., Yang, S. H., Wu, C. W., Sun, H. S., and ＊ Tsai, S. J. (2015) Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod, 21, 894-904 PMID: 26433194
  45. Hsiao, K. Y., Lin, S. C., ＊ Wu, M. H., and ＊ Tsai, S. J. (2015) Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed)7, 309-321PMID: 25553382
  46. Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M., and Yang, S. H. (2015) The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One 10, e0137637 PMID: 26376480
  47. Chuang, J. I., Huang, J. Y., Tsai, S. J., Sun, H. S., Yang, S. H., Chuang, P. C., Huang, B. M., and Ching, C. H. (2015) FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med 89, 274-286 PMID: 26424114
  48. Tang, Y. T., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2014) A semi-supervised, weighted pattern-learning approach for extraction of gene regulation relationships from scientific literature. Int J Data Min Bioinform 9, 401-416 PMID: 25757247
  49. Lin, S. C., Liao, W. L., Lee, J. C., and ＊ Tsai, S. J. (2014) Hypoxia-regulated gene network in drug resistance and cancer progression. Exp Biol Med (Maywood)239, 779-792 PMID: 24812122
  50. Lin, S. C., Li, Y. H., Wu, M. H., Chang, Y. F., Lee, D. K., Tsai, S. Y., Tsai, M. J., and ＊ Tsai, S. J. (2014) Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99, E427-437 PMID: 24423359
  51. Liao, W.-L., Lin, S.-C., Sunny Sun, H., and ＊ Tsai, S. J . (2014) Hypoxia-induced tumor malignancy and drug resistance: Role of microRNAs.Biomarkers and Genomic Medicine 6, 1-11 http://dx.doi.org/10.1016/j.bgm.2014.01.003
  52. Lai, M. S., Cheng, Y. S., Chen, P. R., Tsai, S. J., and Huang, B. M. (2014) Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells. PLoS One 9, e90243 PMID: 24603862
  53. Chen, T. M., Shih, Y. H., Tseng, J. T., Lai, M. C., Wu, C. H., Li, Y. H., ＊ Tsai, S. J. , and ＊ Sun, H. S. (2014) Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 42, 2932-2944 PMID: 24334956
  54. Wu, S. P., Cheng, C. M., Lanz, R. B., Wang, T., Respress, J. L., Ather, S., Chen, W., Tsai, S. J., Wehrens, X. H., Tsai, M. J., and Tsai, S. Y. (2013) Atrial identity is determined by a COUP-TFII regulatory network. Developmental cell 25, 417-426 http://dx.doi.org/10.1016/j.devcel.2013.04.017
  55. Wu, M. H., Chuang, P. C., Lin, Y. J., and ＊Tsai, S. J. (2013) Suppression of annexin A2 by prostaglandin E(2) impairs phagocytic ability of peritoneal macrophages in women with endometriosis. Hum Reprod 28, 1045-1053 PMID:23340055
  56. Wang, H. C., Kooi, T. K., Kao, H. Y., Lin, S. C., and Tsai, S. J. (2013) Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med 43, 2214-2221 PMID:24290938
  57. Qin, J., Wu, S. P., Creighton, C. J., Dai, F., Xie, X., Cheng, C. M., Frolov, A., Ayala, G., Lin, X., Feng, X. H., Ittmann, M. M., Tsai, S. J., Tsai, M. J., and Tsai, S. Y. (2013) COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature 493, 236-240 PMID:23201680
  58. Lai, M. C., Wang, S. W., Cheng, L., Tarn, W. Y., ＊Tsai, S. J., and ＊Sun, H. S. (2013) Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLoS One 8, e68665 PMID:23840900
  59. Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S. J., Lai, Y. Y., Chan, A. W., Chen, C. M., and Yang, S. H. (2013) miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models. Am J Hum Genet 93, 306-312 PMID:23810380
  60. Chen, J. S., Hung, W. S., Chan, H. H., Tsai, S. J., and Sun, H. S. (2013) In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics 29, 420-427 PMID:23267173
  61. Chen, H. M., Lin, Y. H., Cheng, Y. M., Wing, L. Y., and ＊Tsai, S. J. (2013) Overexpression of integrin-beta1 in leiomyoma promotes cell spreading and proliferation. J Clin Endocrinol Metab 98, E837-846 PMID:23482612
  62. Wu, M. H., Lu, C. W., Chang, F. M., and ＊Tsai, S. J. (2012) Estrogen receptor expression affected by hypoxia inducible factor-1alpha in stromal cells from patients with endometriosis. Taiwan J Obstet Gynecol 51, 50-54 http://dx.doi.org/10.1016/j.tjog.2012.01.010
  63. Wiltbank, M. C., Salih, S. M., Atli, M. O., Luo, W., Bormann, C. L., Ottobre, J. S., Vezina, C. M., Mehta, V., Diaz, F. J., Tsai, S. J., and Sartori, R. (2012) Comparison of endocrine and cellular mechanisms regulating the corpus luteum of primates and ruminants. Animal reproduction / Colegio Brasileiro de Reproducao Animal 9, 242-259
  64. Wang, C. C., Lin, S. C., Lee, Y. H., and ＊Tsai, S.J. (2012) Hypoxia-Induced Tumor Progression and Drug Resistance: From Current Understandings to Future Perspectives. Adaptive Medicine 4, 132-144 DOI:10.4247/AM.2012.ABC033
  65. Lin, S. C., Wang, C. C., Wu, M. H., Yang, S. H., Li, Y. H., and ＊Tsai, S. J. (2012) Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab 97, E1515-1523 PMID:22648654
  66. Lin, M. W., Tsai, S. J., Chou, P. Y., Huang, M. F., Sun, H. S., and Wu, M. H. (2012) Vitamin D receptor 1a promotor -1521 G/C and -1012 A/G polymorphisms in polycystic ovary syndrome. Taiwan J Obstet Gynecol 51, 565-571 http://dx.doi.org/10.1016/j.tjog.2012.09.011
  67. Wu, M. H., Lin, S. C., Hsiao, K. Y., and ＊Tsai, S. J. (2011) Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol 225, 390-400 PMID:21984126
  68. Wang, H. C., Chen, Y. H., Kao, H. Y., and ＊Tsai, S. J. (2011) Inference of transcriptional regulatory network by bootstrapping patterns. Bioinformatics 27, 1422-1428 PMID:21450714
  69. Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H., Hsiao, S. H., and Leu, Y. W. (2011) Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer research 71, 4653-4663 PMID:21518779
  70. Tang, Y. T., Li, S. J., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2011) Using unsupervised patterns to extract gene regulation relationships for network construction. PLoS One 6, e19633 PMID:21573008
  71. Lu, C. W., Lin, S. C., Chien, C. W., Lin, S. C., Lee, C. T., Lin, B. W., Lee, J. C., and ＊Tsai, S. J. (2011) Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol 179, 1405-1414 PMID:21763680
  72. Lin, Y. S., Tsai, S. J., Lin, M. W., Yang, C. T., Huang, M. F., and Wu, M. H. (2011) Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism. American journal of reproductive immunology (New York, N.Y. : 1989) 66, 527-533 PMID:21801267
  73. Lin, S. C., Chien, C. W., Lee, J. C., Yeh, Y. C., Hsu, K. F., Lai, Y. Y., Lin, S. C., and ＊Tsai, S. J. (2011) Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest 121, 1905-1916 PMID:21490398
  74. Wu, M. H., Lu, C. W., Chuang, P. C., and ＊Tsai, S. J. (2010) Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood). 235(6), 668-77 PMID:20511671
  75. Wu, M. H., Huang, M. F., Chang, F. M., and ＊Tsai, S. J. (2010) Leptin on peritoneal macrophages of patients with endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989) 63, 214-221 PMID:20047585
  76. Lin, Y. M., Tsai, C. C., Chung, C. L., Chen, P. R., Sun, H. S., ＊Tsai, S. J., and ＊Huang, B. M. (2010) Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells. International journal of andrology 33, 545-553 PMID:19508331
  77. Hsiao, S. H., Lee, K. D., Hsu, C. C., Tseng, M. J., Jin, V. X., Sun, W. S., Hung, Y. C., Yeh, K. T., Yan, P. S., Lai, Y. Y., Sun, H. S., Lu, Y. J., Chang, Y. S., Tsai, S. J., Huang, T. H., and Leu, Y. W. (2010) DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochemical and biophysical research communications 400, 305-312 PMID:20727853
  78. Chuang, P. C., Lin, Y. J., Wu, M. H., Wing, L. Y., Shoji, Y., and ＊Tsai, S. J. (2010) Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol 176, 850-860 PMID:20035060
  79. Chen, W., ＊Tsai, S. J., Sheu, H. M., Tsai, J. C., and Zouboulis, C. C. (2010) Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Experimental dermatology 19, 470-472 PMID:20337700
  80. Chen, T. M., Hsu, C. H., ＊Tsai, S. J., and ＊Sun, H. S. (2010) AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res 38, 8061-8071 PMID:20716519
  81. Pan, H. A., Lee, Y. C., Teng, Y. N., Tsai, S. J., Lin, Y. M., and Kuo, P. L. (2009) CDC25 protein expression and interaction with DAZL in human corpus luteum. Fertility and sterility 92, 1997-2003 PMID:19006796
  82. Chuang, P. C., Wu, M. H., Shoji, Y., and ＊Tsai, S. J. (2009) Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. J Pathol 219, 232-241 PMID:19606481
  83. Chen, W., ＊Tsai, S. J., Wang, C. A., Tsai, J. C., and Zouboulis, C. C. (2009) Human sebocytes express prostaglandin E2 receptors EP2 and EP4 but treatment with prostaglandin E2 does not affect testosterone production. The British journal of dermatology 161, 674-677 PMID:19438438
  84. Yang, C. Y., Wang, Y. J., Chen, P. C., Tsai, S. J., and Guo, Y. L. (2008) Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental health perspectives 116, 599-604 PMID:18470317
  85. Lu, C. W., Lin, S. C., Chen, K. F., Lai, Y. Y., and ＊Tsai, S. J. (2008) Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. The Journal of biological chemistry 283, 28106-28114 PMID:18718909
  86. Hsu, C. C., Lu, C. W., Huang, B. M., Wu, M. H., and ＊Tsai, S. J. (2008) Cyclic adenosine 3',5'-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. Am J Pathol 173, 433-441 PMID:18583320
  87. Chien, C. W., Lin, S. C., Lai, Y. Y., Lin, B. W., Lin, S. C., ＊Lee, J. C., and ＊Tsai, S. J. (2008) Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 14, 8043-8051 PMID:19073968
  88. Wu, M. H., Shoji, Y., Chuang, P. C., and ＊Tsai, S. J. (2007) Endometriosis: disease pathophysiology and the role of prostaglandins. Expert reviews in molecular medicine 9, 1-20 PMID:17227592
  89. Wu, M. H., Chen, K. F., Lin, S. C., Lgu, C. W., and ＊Tsai, S. J. (2007) Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1alpha. Am J Pathol 170, 590-598 PMID:17255327
  90. Chan, H. H., Tsai, S. T., and Sun, H. S. (2007) TAG: a comprehensive database for cancer research. Nucleic Acids Res Molecular Biology Database Collection, # 922
  91. Chen, W., Yang, C. C., Tsai, R. Y., Liao, C. Y., Yen, Y. T., Hung, C. L., Chen, K. F., Tsai, S. J., and Zouboulis, C. C. (2007) Expression of sex-determining genes in the scalp of men with androgenetic alopecia. Dermatology (Basel, Switzerland) 214, 199-204 PMID:17377380
  92. Chen, T. M., Kuo, P. L., Hsu, C. H., Tsai, S. J., Chen, M. J., Lin, C. W., and Sun, H. S. (2007) Microsatellite in the 3' untranslated region of human fibroblast growth factor 9 (FGF9) gene exhibits pleiotropic effect on modulating FGF9 protein expression. Human mutation 28, 98 PMID:17154280
  93. Chuang, P. C., Sun, H. S., Chen, T. M., and ＊Tsai, S. J. (2006) Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cdelta and Elk-1 signaling. Molecular and cellular biology 26, 8281-8292 PMID:16982695
  94. Chen, Y. F., Kou, P. L., Tsai, S. J., Chen, K. F., Chan, H. H., Chen, C. M., and Sun, H. S. (2006) Computational analysis and refinement of sequence structure on chromosome 22q11.2 region: application to the development of quantitative real-time PCR assay for clinical diagnosis. Genomics 87, 290-297 PMID:16307865
  95. Chen, W., Yang, C. C., Liao, C. Y., Hung, C. L., Tsai, S. J., Chen, K. F., Sheu, H. M., and Zouboulis, C. C. (2006) Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne. Journal of the European Academy of Dermatology and Venereology : JEADV 20, 846-852 PMID:16898909
  96. Chen, W., Tsai, S. J., Liao, C. Y., Tsai, R. Y., Chen, Y. J., Pan, B. J., Hung, C. L., and Zouboulis, C. C. (2006) Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia. The Journal of investigative dermatology 126, 2332-2335 PMID:16778788
  97. Wu, M. H., Wang, C. A., Lin, C. C., Chen, L. C., Chang, W. C., and ＊Tsai, S. J. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. J Clin Endocrinol Metab 90, 286-295 PMID:15483103
  98. Wu, M. H., Shoji, Y., Wu, M. C., Chuang, P. C., Lin, C. C., Huang, M. F., and ＊Tsai, S. J. (2005) Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis. Am J Pathol 167, 1061-1069 PMID:16192641
  99. Wing, L. Y., Chen, H. M., Chuang, P. C., Wu, M. H., and ＊Tsai, S. J. (2005) The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation. The Journal of biological chemistry 280, 19937-19947 PMID:15760907
  100. Tsai, S. J., Lin, S. J., Cheng, Y. M., Chen, H. M., and Wing, L. Y. (2005) Expression and functional analysis of pituitary tumor transforming gene-1 [corrected] in uterine leiomyomas. J Clin Endocrinol Metab 90, 3715-3723 PMID:15769981
  101. Chen, W., Chen, G. Y., Tsai, S. J., Wang, P. W., Sheu, H. M., Shen, Y. S., and Chen, F. F. (2005) Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia. Dermatology (Basel, Switzerland) 210, 49-52 PMID:15604546
  102. Chen, K. F., Lai, Y. Y., Sun, H. S., and ＊Tsai, S. J. (2005) Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha. Nucleic Acids Res 33, 5190-5198 PMID:16155188
  103. Wu, M. H., Huang, M. F., Tsai, S. J., Pan, H. A., Cheng, Y. C., and Lin, Y. S. (2004) Effects of laparoscopic ovarian drilling on young adult women with polycystic ovarian syndrome. The Journal of the American Association of Gynecologic Laparoscopists 11, 184-190 PMID:15200772
  104. Huang, B. M., Hsiao, K. Y., Chuang, P. C., Wu, M. H., Pan, H. A., and ＊Tsai, S. J. (2004) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biology of reproduction 70, 1358-1364 PMID:14711788
  105. Wu, M. H., Tsai, S. J., Pan, H. A., Hsiao, K. Y., and Chang, F. M. (2003) Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization. Ultrasound Obstet Gynecol 21, 480-485 PMID:12768561
  106. Wing, L. Y., Chuang, P. C., Wu, M. H., Chen, H. M., and ＊Tsai, S. J. (2003) Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab 88, 5547-5554 PMID:14602803
  107. Vasconcelos, J. L., Sangsritavong, S., Tsai, S. J., and Wiltbank, M. C. (2003) Acute reduction in serum progesterone concentrations after feed intake in dairy cows. Theriogenology 60, 795-807 PMID:12935858
  108. Sun, H. S., Hsiao, K. Y., Hsu, C. C., Wu, M. H., and ＊Tsai, S. J. (2003) Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. Endocrinology 144, 3934-3942 PMID:12933667
  109. Ip, S. P., Wong, T. P., Tsai, S. J., and Leung, P. S. (2003) The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition. Journal of molecular endocrinology 31, 563-571 PMID:14664716
  110. Hsu, C. C., ＃Tsai, S. J., Huang, Y. L., and Huang, B. M. (2003) Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS letters 543, 140-143 PMID:12753921
  111. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. (2003) In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 73, 2127-2136 PMID:12899935
  112. Yang, A. L., Tsai, S. J., Jiang, M. J., Jen, C. J., and Chen, H. I. (2002) Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta. Journal of biomedical science 9, 149-155 PMID:11914582
  113. Wu, M. H., Sun, H. S., Lin, C. C., Hsiao, K. Y., Chuang, P. C., Pan, H. A., and ＊Tsai, S. J. (2002) Distinct mechanisms regulate cyclooxygenase-1 and-2 in peritoneal macrophages of women with and without endometriosis. Molecular Human Reproduction 8, 1103-1110 PMID:12468643
  114. Wu, M. H., Chuang, P. C., Chen, H. M., Lin, C. C., and ＊Tsai, S. J. (2002) Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation. Mol Hum Reprod 8, 456-464 PMID:11994543
  115. Tsai, S. J., Wu, M. H., Chen, H. M., Chuang, P. C., and Wing, L. Y. (2002) Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology 143, 2715-2721 PMID:12072406
  116. Pan, H. A., Tsai, S. J., Chen, C. W., Lee, Y. C., Lin, Y. M., and Kuo, P. L. (2002) Expression of DAZL protein in the human corpus luteum. Mol Hum Reprod 8, 540-545 PMID:12029071
  117. Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S. J., Lin, J. S., and Kuo, P. L. (2002) Presence of DAZL transcript and protein in mature human spermatozoa. Fertility and sterility 77, 626-629 PMID:11872225
  118. Diaz, F. J., Anderson, L. E., Wu, Y. L., Rabot, A., Tsai, S. J., and Wiltbank, M. C. (2002) Regulation of progesterone and prostaglandin F2alpha production in the CL. Molecular and cellular endocrinology 191, 65-80 PMID:12044920
  119. Tsai, S. J., Wu, M. H., Lin, C. C., Sun, H. S., and Chen, H. M. (2001) Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab 86, 5765-5773 PMID:11739437
  120. Tsai, S. J., Wu, M. H., Chuang, P. C., and Chen, H. M. (2001) Distinct regulation of gene expression by prostaglandin F(2alpha) (PGF(2alpha)) is associated with PGF(2alpha) resistance or susceptibility in human granulosa-luteal cells. Mol Hum Reprod 7, 415-423 PMID:11331663
  121. Tsai, S. J., and Wiltbank, M. C. (2001) Differential effects of prostaglandin F2alpha on in vitro luteinized bovine granulosa cells. Reproduction (Cambridge, England) 122, 245-253 PMID:11467975
  122. Tsai, S. J., Kot, K., Ginther, O. J., and Wiltbank, M. C. (2001) Temporal gene expression in bovine corpora lutea after treatment with PGF2alpha based on serial biopsies in vivo. Reproduction (Cambridge, England) 121, 905-913 PMID:11373177
  123. Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S. J., Hsu, C. C., Teng, Y. N., Lin, J. S., and Kuo, P. L. (2001) Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men. Mol Hum Reprod 7, 1015-1022 PMID:11675467
  124. Leung, P. S., Tsai, S. J., Wallukat, G., Leung, T. N., and Lau, T. K. (2001) The upregulation of angiotensin II receptor AT(1) in human preeclamptic placenta. Molecular and cellular endocrinology 184, 95-102 PMID:11694345
  125. Huang, B. M., Hsu, C. C., Tsai, S. J., Sheu, C. C., and Leu, S. F. (2001) Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells. Life Sci 69, 2593-2602 PMID:11712663
  126. Anderson, L. E., Wu, Y. L., Tsai, S. J., and Wiltbank, M. C. (2001) Prostaglandin F(2alpha) receptor in the corpus luteum: recent information on the gene, messenger ribonucleic acid, and protein. Biology of reproduction 64, 1041-1047 PMID:11259248
  127. Kot, K., Anderson, L. E., Tsai, S. J., Wiltbank, M. C., and Ginther, O. J. (1999) Transvaginal, ultrasound-guided biopsy of the corpus luteum in cattle. Theriogenology 52, 987-993 PMID:10735106
  128. Tsai, S. J., and Wiltbank, M. C. (1998) Prostaglandin F2alpha regulates distinct physiological changes in early and mid-cycle bovine corpora lutea. Biology of reproduction 58, 346-352 PMID:9475388
  129. Tsai, S. J., Anderson, L. E., Juengel, J., Niswender, G. D., and Wiltbank, M. C. (1998) Regulation of prostaglandin F2 alpha and E receptor mRNA by prostaglandin F 2 alpha in ovine corpora lutea. Journal of reproduction and fertility 114, 69-75 PMID:9875157
  130. Tsai, S. J., and Wiltbank, M. C. (1997) Prostaglandin F2alpha induces expression of prostaglandin G/H synthase-2 in the ovine corpus luteum: a potential positive feedback loop during luteolysis. Biology of reproduction 57, 1016-1022 PMID:9369165
  131. Tsai, S. J., Juengel, J. L., and Wiltbank, M. C. (1997) Hormonal regulation of monocyte chemoattractant protein-1 messenger ribonucleic acid expression in corpora lutea. Endocrinology 138, 4517-4520 PMID:9322976
  132. Burns, P. D., Tsai, S. J., Wiltbank, M. C., Hayes, S. H., Graf, G. A., and Silvia, W. J. (1997) Effect of oxytocin on concentrations of prostaglandin H synthase-2 mRNA in ovine endometrial tissue in vivo. Endocrinology 138, 5637-5640 PMID:9389552
  133. Tsai, S. J., Wiltbank, M. C., and Bodensteiner, K. J. (1996) Distinct mechanisms regulate induction of messenger ribonucleic acid for prostaglandin (PG) G/H synthase-2, PGE (EP3) receptor, and PGF2 alpha receptor in bovine preovulatory follicles. Endocrinology 137, 3348-3355 PMID:8754761
  134. Tsai, S. J., and Wiltbank, M. C. (1996) Quantification of mRNA using competitive RT-PCR with standard-curve methodology. Biotechniques 21, 862-866 PMID:8922627
  135. Duello, T. M., Tsai, S. J., and Van Ess, P. J. (1993) In situ demonstration and characterization of progonadotropin-releasing hormone messenger ribonucleic acid in first trimester human placentas. Endocrinology 133, 2617-2623 PMID:8243285
  136. Yuan, C. C., Tsai, L. C., Hsu, S. C., Ng, H. T., Tsai, S. J., Chen, H. M., Hung, M. W., Ho, C. K., Ho, D. M., and Gill, T. J., 3rd. (1992) Production and characterisation of a monoclonal antibody (Cx-99) against cervical carcinoma. Br J Cancer 65, 201-207 PMID:1739618
  137. Tsai, L. C., Tang, R. B., Hung, M. W., Chen, H. M., and Tsai, S. J. (1990) Expression of serum IL-2, IL-2R, and CD8 levels during hyposensitization in house-dust-sensitive asthmatics. J Asthma 27, 307-313 PMID:2122966
  138. Tsai, L.C., Hung, M. W., Chen, H.M., Chang, Z.N., and Tsai, S.J. (1989) Measurement of specific IgE antibody in mite-sensitive asthmatic children by enzyme-linked immunosorbent assay. Chin Med J (Taipei) 44, 352-357
  139. Yuan, C. C., Tsai, L. T., Tsai, S. J., Hsu, S. C., Ho, D. M., Chen, H. M., Hung, M. W., Lee, L. C., and Ng, H. T. (1989) Immunohistochemical study of carcinoembryonic antigen in cervical cancer-using a monoclonal antibody Mab C27. Chin Med J (Taipei) 44, 341-346

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