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Fong-Sen Wu

Fong-Sen Wu, Associate Professor


Education and Experience:

B.S. National Taiwan University, 1972-1976

M.S. National Taiwan University, 1978-1980

T.A. National Taiwan University, 1980-1982

Ph.D. Johns Hopkins University, 1982-1988

Research Assistant Professor, Boston University, 1991-1993

Associate Professor, National Cheng Kung University, 1993-present


Neurophysiology in PNS and CNS, Synaptic Plasticity, Behavioral Neuroscience


2009  Outstanding Teacher Award of National Cheng Kung University




82-0714 ext. 5455


82-0752 ext. 5434

Hobbies: Music, Travelling, Popular Science, Biography

Research interests

1. Mechanisms underlying sex differences in capsaicin-induced nociception in rats

2. Mechanisms underlying exercise training-induced enhancement of long-term potentiation in the rat limbic system

3. Mechanisms underlying sex differences in long-term potentiation in the rat amygdala


Current member

Ms.D student: Wei-Ju Lee (2nd year)

Former member

Ph.D student: Shu-Cheng Chen (2005

Ms.D student: Chih-Wei Chen (2016), Han-Tsung Chi (2014), Ya-Han Hsu (2013), Chih-Hsuan Liu (2012), Dylan Chou (2010), Su-Yi Wang (2009), Yu-Chun Ho (2008), Chao-Wei Chen (2007),Yu-Ching Lu (2006), Wei-Bin Lai (2004), Tsui-Jung Chang (2002), Pi-Lian Kao (2002), Bie-Ching Liu (2001), Guo-Wei Tang (2001), Li-Kai Cheng (2000), Cheng-Pou Lai (1998), Ying-Chen Yang (1998), Hui-Min Yu (1997), Shu-Cheng Chen (1996)

Publication listPubMed Lik

1.         Hsu YC, Tsai SF, Yu L, Chuang JI, Wu FS, Jen CJ, Kuo YM*. 2016. Long-term moderate exercise accelerates the recovery of stress-evoked cardiovascular responses. Stress. 19:125-132.

2.         Tsou YH, Shih CT, Ching CH, Huang JY, Jen CJ, Yu L, Kuo YM, Wu FS, Chuang JI*. 2015. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Exp. Neurol. 263:50-62.

3.         Huang TY, Lin LS, Cho KC, Chen SJ, Kuo YM, Yu L, Wu FS, Chuang JI, Chen HI, Jen CJ*. 2012. Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. J. Appl. Physiol. 113:889-895.

4.         Lin TW, Chen SJ, Huang TY, Chang CY, Chuang JI, Wu FS, Kuo YM*, Jen CJ*. 2012. Different types of exercise induce differential effects on neuronal adaptations and memory performance. Neurobiol. Learn. Mem. 97:140-147.

5.         Hsu YC, Chen HI, Kuo YM, Yu L, Huang TY, Chen SJ, Chuang JI, Wu FS, Jen CJ*. 2011. Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic system. J. Hypertens. 29:2339-2348.

6.         Chang YS, Lin CF, Wu CL, Kuo PY, Wu FS, Shieh CC, Gean PW, Chen ST, Chen MS, Wu WC, Tai MH, Tseng SH*. 2011. Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells. Invest. Ophthalnol. Vis. Sci. 52:4214-4222.

7.         Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS, Wu CW, Kuo YM*. 2011. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav. Immu. 25:135-146.

8.         Lu YC, Chen CW, Wang SY, Wu FS*. 2009. 17b-Estradiol mediates the sex difference in capsaicin-induced nociception in rats. J. Pharmacol. Exp. Ther. 331:1104-1110.

9.         Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Huang AM, Wu FS, Chuang JI*, Jen CJ*. 2009. Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I. J. Physiol. 587.13:3221-3231.

10.     Liu YF, Chen HI, Yu L, Kuo YM, Wu FS, Chuang JI, Liao PC, Jen CJ*. 2008. Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiol. Learn. Mem. 90:81-89.

11.     Chen HI, Lin LC, Yu L, Liu YF, Kuo YM, Huang AM, Chuang JI, Wu FS, Liao PC, Jen CJ*. 2008. Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system. Neurobiol. Learn. Mem. 89:489-496.

12.     Chen SC, Liu BC, Chen CW, Wu FS*. 2006. Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats. Biochem. Biophys. Res. Commu. 349:626-633.

13.     Chen SC, Wu FS*. 2004. Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons. Brain Res. 1027:196-200.

14.     Chen SC, Chang TJ, Wu FS*. 2004. Competitive inhibition of the capsaicin receptor-mediated current by dehydroepiandrosterone in rat dorsal root ganglion neurons. J. Pharmacol. Exp. Ther. 311:529-536.

15.     Wu FS*, Yang YC, Tsai JJ. 2000. Noncompetitive inhibition of the glycine receptor-mediated current by melatonin in cultured neurons. Brain Res. 881:208–211.

16.     Wu FS*, Lai CP, Liu BC. 2000. Non-competitive inhibition of 5-HT3 receptor-mediated currents by progesterone in rat nodose ganglion neurons. Neurosci. Lett. 278:37-40.

17.     Wu FS*, Yang YC, Tsai JJ. 1999. Melatonin potentiates the GABAA receptor-mediated current in cultured chick spinal cord neurons. Neurosci. Lett. 260:177-180.

18.     Weaver Jr. CE, Wu FS, Gibbs TT, Farb DH*. 1998. Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons. Brain Res. 803:129-136.

19.     Wu FS*, Yu HM, Tsai JJ. 1998. Mechanism underlying potentiation by progesterone of the kainite-induced current in cultured neurons. Brain Res. 779:354-358.

20.     Park-Chung M, Wu FS, Purdy RA, Malayev AA, Gibbs TT, Farb DH*. 1997. Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. Mol. Pharmacol. 52:1113-1123.

21.     Wu FS*, Chen SC, Tsai JJ. 1997. Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons. Brain Res. 750:318–320.

22.     Wu FS*, Chen SC. 1997. Mechanism underlying the effect of pregnenolone sulfate on the kainite-induced current in cultured chick spinal cord neurons. Neurosci. Lett. 222:79-82.

Laboratory View

Laboratory activities