吳豐森（Fong-Sen Wu）副教授

學經歷：

國立台灣大學 學士，1972-1976

國立台灣大學 碩士，1978-1980

國立台灣大學 助教，1980-1982

美國約翰霍浦金斯大學 博士，1982-1988

美國波士頓大學 助理研究教授，1991- 1993

成大生理所 副教授，1993-迄今

專長學科 ：

週邊神經生理學、中樞神經生理學、突觸可塑性、行為神經科學

獎勵事項 ：

2009 : 國立成功大學97學年度教學優良教師

E-mail

fongsen@mail.ncku.edu.tw

辦公室

82-0714 分機：5455

實驗室

82-0752 分機：5434

嗜好：音樂、旅遊、科普、傳記文學

研究方向及興趣：

1. 辣椒素誘發大白鼠產生痛覺反應之性別差異的機制

2. 運動訓練對大白鼠邊緣系統長期增益現象之增強作用的機制

3. 大白鼠杏仁核長期增益現象之性別差異的機制

實驗室成員：

現在成員

碩士班：李維儒 (碩二)

過去成員

博士班：陳淑貞 (2005)

碩士班：陳致維 (2016)、紀瀚雄 (2014)、許雅涵 (2013)、劉智璿(2012)、周迪侖 (2010)、王思懿 (2009)、賀豫君 (2008)、陳兆偉 (2007)、呂雨青 (2006)、賴維斌 (2004)、張翠容 (2002)、高碧蓮 (2002)、劉碧菁 (2001)、唐國威 (2001)、鄭吏凱 (2000)、賴建伯(1998)、楊瀅臻 (1998)、游惠敏 (1997)、陳淑貞 (1996)

相關著作（PubMed連結）

1.         Hsu YC, Tsai SF, Yu L, Chuang JI, Wu FS, Jen CJ, Kuo YM*. 2016. Long-term moderate exercise accelerates the recovery of stress-evoked cardiovascular responses. Stress. 19:125-132.

2.         Tsou YH, Shih CT, Ching CH, Huang JY, Jen CJ, Yu L, Kuo YM, Wu FS, Chuang JI*. 2015. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP⁺ toxicity. Exp. Neurol. 263:50-62.

3.         Huang TY, Lin LS, Cho KC, Chen SJ, Kuo YM, Yu L, Wu FS, Chuang JI, Chen HI, Jen CJ*. 2012. Chronic treadmill exercise in rats delicately alters the Purkinje cell structure to improve motor performance and toxin resistance in the cerebellum. J. Appl. Physiol. 113:889-895.

4.         Lin TW, Chen SJ, Huang TY, Chang CY, Chuang JI, Wu FS, Kuo YM*, Jen CJ*. 2012. Different types of exercise induce differential effects on neuronal adaptations and memory performance. Neurobiol. Learn. Mem. 97:140-147.

5.         Hsu YC, Chen HI, Kuo YM, Yu L, Huang TY, Chen SJ, Chuang JI, Wu FS, Jen CJ*. 2011. Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic system. J. Hypertens. 29:2339-2348.

6.         Chang YS, Lin CF, Wu CL, Kuo PY, Wu FS, Shieh CC, Gean PW, Chen ST, Chen MS, Wu WC, Tai MH, Tseng SH*. 2011. Mechanisms underlying benzyl alcohol cytotoxicity (triamcinolone acetonide preservative) in human retinal pigment epithelial cells. Invest. Ophthalnol. Vis. Sci. 52:4214-4222.

7.         Wu SY, Wang TF, Yu L, Jen CJ, Chuang JI, Wu FS, Wu CW, Kuo YM*. 2011. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain Behav. Immu. 25:135-146.

8.         Lu YC, Chen CW, Wang SY, Wu FS*. 2009. 17b-Estradiol mediates the sex difference in capsaicin-induced nociception in rats. J. Pharmacol. Exp. Ther. 331:1104-1110.

9.         Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Huang AM, Wu FS, Chuang JI*, Jen CJ*. 2009. Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I. J. Physiol. 587.13:3221-3231.

10.     Liu YF, Chen HI, Yu L, Kuo YM, Wu FS, Chuang JI, Liao PC, Jen CJ*. 2008. Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice. Neurobiol. Learn. Mem. 90:81-89.

11.     Chen HI, Lin LC, Yu L, Liu YF, Kuo YM, Huang AM, Chuang JI, Wu FS, Liao PC, Jen CJ*. 2008. Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system. Neurobiol. Learn. Mem. 89:489-496.

12.     Chen SC, Liu BC, Chen CW, Wu FS*. 2006. Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats. Biochem. Biophys. Res. Commu. 349:626-633.

13.     Chen SC, Wu FS*. 2004. Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons. Brain Res. 1027:196-200.

14.     Chen SC, Chang TJ, Wu FS*. 2004. Competitive inhibition of the capsaicin receptor-mediated current by dehydroepiandrosterone in rat dorsal root ganglion neurons. J. Pharmacol. Exp. Ther. 311:529-536.

15.     Wu FS*, Yang YC, Tsai JJ. 2000. Noncompetitive inhibition of the glycine receptor-mediated current by melatonin in cultured neurons. Brain Res. 881:208–211.

16.     Wu FS*, Lai CP, Liu BC. 2000. Non-competitive inhibition of 5-HT₃ receptor-mediated currents by progesterone in rat nodose ganglion neurons. Neurosci. Lett. 278:37-40.

17.     Wu FS*, Yang YC, Tsai JJ. 1999. Melatonin potentiates the GABA_A receptor-mediated current in cultured chick spinal cord neurons. Neurosci. Lett. 260:177-180.

18.     Weaver Jr. CE, Wu FS, Gibbs TT, Farb DH*. 1998. Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons. Brain Res. 803:129-136.

19.     Wu FS*, Yu HM, Tsai JJ. 1998. Mechanism underlying potentiation by progesterone of the kainite-induced current in cultured neurons. Brain Res. 779:354-358.

20.     Park-Chung M, Wu FS, Purdy RA, Malayev AA, Gibbs TT, Farb DH*. 1997. Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids. Mol. Pharmacol. 52:1113-1123.

21.     Wu FS*, Chen SC, Tsai JJ. 1997. Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons. Brain Res. 750:318–320.

22.     Wu FS*, Chen SC. 1997. Mechanism underlying the effect of pregnenolone sulfate on the kainite-induced current in cultured chick spinal cord neurons. Neurosci. Lett. 222:79-82.

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