Shian-Jang Yan
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Shian-Jang (John) Yan, Assitant Professor |
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Education and Experience: B.S. Department of Zoology/Life Science, National Taiwan University, 1995 Ph.D. University of Rochester, 2005 Joined Cheng Kung University Faculty, 2012
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Speciality: Epigenetics, Genetics, Developmental Biology, Cell Biology, Molecular Biology, Human disease model |
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Award: 2009-2012 Ruth L. Kirschstein National Research Service Award, NIH, USA |
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johnyan@mail.ncku.edu.tw |
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Office |
82-0732 ext. 5437 |
Laboratory |
82-0739 ext. 5444 |
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Hobbies: Bicycling , Outdoor adventures, Traveling, Basketball |
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Research interests： |
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1. How cells of different types, but with the same genome, maintain their identities and functions over time involves epigenetic processes. These processes must be tightly regulated to prevent inappropriate cell behavior and function that can lead to human diseases such as cancer and premature aging. 2. However, despite the recent advances in decoding the human genome, we know very little as to how the epigenetic “memory” of cellular identity and function is maintained. My approach to this question is to study how cells integrate extracellular information, obtained through signaling pathways, and intracellular cues, through nuclear factors, to elicit appropriate epigenetic responses in various biological situations. 3. Using the genetically tractable in vivo system of Drosophila melanogaster, I plan to investigate the molecular and cellular mechanisms by which regulatory networks connecting signal transduction pathways (extrinsic factors) and chromatin factors (intrinsic factors) control epigenetic memory in the context of tumorigenesis, aging, stem cell maintenance, and genome stability. |
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People: |
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Current member Postdoc: Nancy Chen Ph.D. students: Eric Wu, Justin Chang, Ali Zain M.S. students: Vivian Chen, Hank Song, Ya-Yuan Hu, Winnie Tseng Former member Ph.D. students: Nancy Chen (2022), Tim Mao (2021) M.S. students: Marjorie Chin (2021), Jennifer Tan (2020), Sherry Liu (2019), Can Lai (2018), John Liu (2018), Justin Chang (2017), Nancy Chen (2016), Eric Wu (2015), Kelly Chen (2015), Katy Shen (2015), Doris Huang (2015) Undergraduates: Bryan Lee, Guan-Yi Li, Cathryn Chen |
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Publication list（PubMed Lik） |
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(5 year IFs and ranking by JIF (R/C) are based on the latest JCR 2021) 1.Po-Jen Wu, Shian-Jang Yan* (2022, Oct). HP1a-mediated heterochromatin formation promotes antimicrobial responses against Pseudomonas aeruginosa infection. BMC Biology, 20(234):1-16. London, United Kingdom. 5 year IF=8.641. R/C=10/94, BIOLOGY. 2.Bin-Hsu Mao, Yi-Kai Luo, Bour-Jr Wang, Chun-Wan Chen, Fong-Yu Cheng, Yu-Hsuan Lee, Shian-Jang Yan*, Ying-Jan Wang* (2022, Jan). Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo. Particle and Fibre Toxicology, 19(6): 1-25. London, United Kingdom. 5 year IF=9.14. R/C=4/94, TOXICOLOGY. 3.Che-Wei Chang, Yu-Chia Shen, and Shian-Jang Yan* (2021, Dec). HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression. Cell Death & Disease, 12(1130), 1-12. London, United Kingdom. 5 year IF=9.62. R/C=36/195, CELL BIOLOGY. 4.Chia-Jung Yu#, Dian W. Damaiyanti#, Shian-Jang Yan, Chih-Hsing Wu, Ming-Jer Tang, Dar-Bin Shieh, Peter P. Liu and Ping-Yen Liu (2021, Dec). The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes. International Journal of Molecular Sciences, 22, 13281, 1-13. Basel, Switzerland. 5 year IF=6.628. R/C=69/297, BIOCHEMISTRY & MOLECULAR BIOLOGY. 5.Zi-Yu Chen, Yu-Chen Su, Fong-Yu Cheng, Shian-Jang Yan*, and Ying-Jan Wang* (2021, Dec). Lifetime bioaccumulation of silver nanoparticles accelerates functional aging by inactivating antioxidant pathways, an effect reversed by pterostilbene. Environmental Science-Nano, 8, 3774-3791. London, United Kingdom. 5 year IF=9.35. R/C=29/279, ENVIRONMENTAL SCIENCES. 6.DJ Klionsky...Shian-Jang Yan...et al. (2021, Jan). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1):1-382. 5 year IF=16.142. R/C=22/195, CELL BIOLOGY. 7.Guan-Rong Lai, Yi-Fen Lee, Shian-Jang Yan*, Huei-Ju Ting* (2020, May). Active vitamin D induced gene-specific hypomethylation in prostate cancer cells developing vitamin D resistance. American Journal of Physiology-Cell Physiology, 318: C836-847. Bethesda, United States of America. 5 year IF=5.225, R/C=14/81, PHYSIOLOGY. 8.Zi-Yu Chen†, Nian-Jhen Li, Fong-Yu Cheng, Jian-Feng Hsueh, Chiao-Ching Huang, Fu-I Lu, Tzu-Fun Fu, Shian-Jang Yan†, Yu-Hsuan Lee*, and Ying-Jan Wang* (2020, Apr). The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos. International Journal of Molecular Sciences, 21(8), 2864: 1-20. Basel, Switzerland. 5 year IF=6.628. R/C=69/297, BIOCHEMISTRY & MOLECULAR BIOLOGY. 9.Rong-Jane Chen, Yu-Ying Chen, Mei-Yi Liao, Yu-Hsuan Lee, Zi-Yu Chen, Shian-Jang Yan, Ya-Ling Yeh, Li-Xing Yang, Yen-Ling Lee, Yuan-Hua Wu*, Ying-Jan Wang* (2020, Mar). The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies. International Journal of Molecular Sciences, 21(7), 2387: 1-24. Basel, Switzerland. 5 year IF=6.628. R/C=69/297, BIOCHEMISTRY & MOLECULAR BIOLOGY. 10.Bin-Hsu Mao, Zi-Yu Chen, Ying-Jang Wang* & Shian-Jang Yan* (2018, Feb). Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses. Scientific Reports, 8: 2445, 1-16. London, United Kingdom. 5 year IF=5.516. R/C=19/74, MULTIDISCIPLINARY SCIENCES. 11.Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, Hsin-Su Yu, Mami Noda, Chi-Yu Lu, Chu-Huang Chen, Shian-Jang Yan*, Tohru Yoshioka* (2017, Jun). Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. Scientific Reports, 7 (3606): 1-11. London, United Kingdom. 5 year IF=5.516. R/C=19/74, MULTIDISCIPLINARY SCIENCES. 12.Bin-Hsu Mao, Jui-Chen Tsai, Chun-Wan Chen, Shian-Jang Yan*, Ying-Jan Wang* (2016, Oct). Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy. Nanotoxicology, 10(8):1021-40. Milton Park, United Kingdom. 5 year IF=6.319. R/C=13/94, TOXICOLOGY. 13.Wen-Li Hsu, Jian-He Lu, Mami Noda, Ching-Ying Wu, Jia-dai Liu, Manabu Sakakibara, Ming-Hsien Tsai, Hsin-Su Yu, Ming-Wei Lin, Yaw-Bin Huang, Shian-Jang Yan*, Tohru Yoshioka* (2015, Nov). Derinat Protects Skin against Ultraviolet-B (UVB)-Induced Cellular Damage. Molecules, 20(11):20297-311. Basel, Switzerland. 5 year IF=5.11. R/C=65/179, CHEMISTRY, MULTIDISCIPLINARY. 14.Amy Tsurumi, Pranabanada Dutta, Shian-Jang Yan, Robin Sheng, Willis X. Li* (2013, Oct). Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Scientific Reports, 3:1-9. London, United Kingdom. 5 year IF=5.516. R/C=19/74, MULTIDISCIPLINARY SCIENCES. 15.Kriti Gaur, Jinghong Li, Dakun Wang, Pranabananda Dutta, Shian-Jang Yan, Amy Tsurumi, Hartmut Land, Guan Wu, Willis X. Li* (2013, Jan). The Birt-Hogg-Dube tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis. Human Molecular Genetics, 22(2), 284-299. Oxford, England. 5 year IF=5.999. R/C=36/175, GENETICS & HEREDITY. 16.Shian-Jang Yan#, Yi-Fen Lee#, Huei-Ju Ting#, Ning-Chun Liu, Su Liu, Shin-Jen Lin, Shauh-Der Yeh, Gonghui Li, Chawnshang Chang* (2012, Jun). Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. CELLULAR & MOLECULAR BIOLOGY LETTERS, 17(2), 309-22. London, United Kingdom. 5 year IF=7.36, R/C=41/297, BIOCHEMISTRY & MOLECULAR BIOLOGY. 17.Huei-Ju Ting, Sayeda Yasmin-Karim, Shian-Jang Yan, Jong-Wei Hsu, Tzu-Hua Lin, Weisi Zeng, James Messing, Tzong-Jeng Sheu, Bo-Ying Bao, Willis X. Li, Edward Messing, Yi-Fen Lee* (2012, Feb). A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. CANCER RESEARCH, 72, 958-968. Philadelphia, United States of America. 5 year IF=13.678. R/C=20/245, ONCOLOGY. 18.Kimberly Larson#, Shian-Jang Yan#, Amy Tsurumi#, Jacqueline Liu#, Jun Zhou, Kriti Gaur, Dongdong Guo, Thomas H. Eickbush, Willis X. Li* (2012, Jan). Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genetics, 8(1): 1-10. San Francisco, United States of America. 5 year IF=6.514. R/C=27/175, GENETICS & HEREDITY. 19.Su Liu#, Shian-Jang Yan#, Yi-Fen Lee, Ning-Chun Liu, Huei-Ju Ting, Gonghui Li, Qiao Wu, Lu-Min Chen, Chawnshang Chang* (2011, Nov). The testicular nuclear receptor 4 (TR4) regulates UV-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(44):38103-8. Amsterdam, Netherlands. 5 year IF=5.294. R/C=94/297, BIOCHEMISTRY & MOLECULAR BIOLOGY. 20.Shian-Jang Yan, Su Jun Lim, Song Shi, Pranabananda Dutta, Willis X. Li* (2011, Jan). Unphosphorylated STAT and heterochromatin protect genome stability. FASEB JOURNAL, 25, 232-41. Hoboken, United States of America. 5 year IF=6.103. R/C=16/94, BIOLOGY. 21.Shian-Jang Yan, Jeremiah J Zartman, Minjie Zhang, Anthony Scott, Stanislav Y Shvartsman*, Willis X. Li* (2009, Jun). Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Molecular Systems Biology, 5 (278), 1-7. Hoboken, United States of America. 5 year IF=12.904, R/C=20/297, BIOCHEMISTRY & MOLECULAR BIOLOGY. 22.Fan Xia, Jinghong Li, Gavin W Hickey, Amy Tsurumi, Kimberly Larson, Dongdong Guo, Shian-Jang Yan, Louis Silver-Morse, Willis X. Li* (2008, May). Raf activation is regulated by Tyrosine 510 phosphorylation in Drosophila. PLoS Biology, 6, 1115-1129. San Francisco, United States of America. 5 year IF=10.462. R/C=6/94, BIOLOGY. 23.Song Shi, Kimberly Larson, Dongdong Guo, Su Jun Lim, Pranabananda Dutta1, Shian-Jang Yan, Willis X. Li* (2008, Mar). Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. NATURE CELL BIOLOGY, 10, 489-96. London, United Kingdom. 5 year IF=28.123. R/C=9/195, CELL BIOLOGY. 24.Shian-Jang Yan, Yi Gu, Willis X. Li*, Robert J Fleming* (2004, Jan). Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development, 131, 285-98. Cambridge, United Kingdom. 5 year IF=7.795. R/C=5/39, DEVELOPMENTAL BIOLOGY. 25.Jiann-Horng Leu, Shian-Jang Yan, Tzuu-Fen Lee, Chih-Ming Chou, Shui-Tsung Chen, Pung-Pung Hwang, Chen-Kung Chou, Chang-Jen Huang* (2000, Jul). Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes. DNA AND CELL BIOLOGY, 19, 431-46. New Rochelle, United States of America. 5 year IF=3.557. R/C=85/175, GENETICS & HEREDITY. |
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Laboratory View |
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