Pei-Chun Chen
Pei-Chun Chen, Associate Professor |
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Education and Experience: · B.S. in Medical Technology, Chang-Gung University, 1996-2000 · Ph.D.in the Graduate Institute of Basic Medicine, Chang-Gung University, 2000-2006 · Postdoctoral researcher in U Chicago, 2006-2007 · Postdoctoral researcher in UW-Madison, 2007-2009 · Postdoctoral researcher in Oregon Health and Science University , 2009-2014 · Assistant Profession, 2014 ~2018 · Associate Profession, 2018 ~
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Specialty: Neurodegenerative diseases, neuroscience, molecular biology, cell biology, potassium channel trafficking, insulin secretion related mechanism and disease |
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Award: 2015 “Paper of the Week” by J. Biol. Chem 2014 “Paper of the Week” by J. Biol. Chem 2013 Travel and Best Poster Awards for Postdoctoral fellows from American society of Biochemistry and Molecular Biology (ASBMB) 2011-2012 Post-doctoral Trainee, National Institute of Diabetic and Digestive and Kidney Diseases, Center Training Grant T32 DK007680 2010 Tartar Award, Oregon Health and Science University |
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pcchen@mail.ncku.edu.tw |
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Office |
82-0704 ext. 5423 |
Laboratory |
82-0736 ext. 5427 |
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Hobbies: Traveling, playing with my son, watch criminal TV shows, reading |
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Research interests: |
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Three channels that we are currently focusing on are ATP sensitive potassium channel (KATP), voltage gated potassium channel 2.1 and calcium regulated potassium channels. We study roles of these channels in diabetes, obesity, Parkinson’s disease and neural development. Example 1: we would study nervous and pancreatic systems together. Diabetes has traditionally been thought of as a peripheral metabolic disease, but the central nervous system also plays a role in regulating glucose homeostasis. The autonomic nervous system and hypothalamus-pituitary-adrenal axis both work together to regulate metabolic responses to changes in energy requirement and plasma glucose concentration. Example 2: we study these channels in the pathogenesis of Parkinson’s disease, and we are especially interested to know role of these channels in the circuit of basal ganglia. Research approaches are included: l Protein trafficking, ion channel regulation and islet cell biology l Electrophysiology, cell and molecular biology techniques l Rodent experiments: stereotaxic microinjection of 6-OH-DA, subchronic MPTP model, behavioral assessments |
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People: |
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Current member
PhD students : Yi-Ying Kuo (2018) Master students : Yu-Chi Lin (2017), Wan-Chen Ho (2017), Liang-Chu Chang (2018), Yi-Qian You (2019), Yi-Chun Lin (2019), SIH-Yu Pan (2019)
Former member Master students : Kui Ming Hung (2014) 、Ru Yi Chao (2015)、Jing-Syuna Ruan (2015)、Jie-Kuan Lin (2016)、Chia-Hui Cheng (2016) |
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Publication list(PubMed Link) |
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1. Ruan JS, Lin JK, Kuo YY, Chen YW, Chen PC (2018) Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic beta cells. The Journal of nutritional biochemistry 59:37-48. 12. Y. Wu, S.L. Shyng, P.C. Chen (2015), Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells. J Biol Chem, 290:29676-29690. "Paper of the Week”, J Biol Chem podcast on Dec 11, 2015. 13. Q Zhou, P.C. Chen, P.K. Devaraneni, G.M. Martin, E.M Olson, S.L. Shyng, (2014) Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels, 8:376-382 14. P.C. Chen, Y. Kryukova, S.L. Shyng, (2013), Leptin regulates KATP channel trafficking in pancreatic b-cells by a signaling mechanism involving AMPK and PKA to the plasma membrane. J Biol Chem 288:34098-34109. "Paper of the Week." And A figure from the paper was selected for the Nov. 22 cover of JBC 15. G. Martin, P.C. Chen, P. Devaraneni, S.L. Shyng, (2013), Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels. Front Physiol. Dec 24;4:386. eCollection. 16. P.C. Chen , E. Olson, Q. Zhou , Y. Kryukova , H. Sampson ,D.Y. Thomas, S.L. Shyng (2013), Carbamazepine as a Novel Small Molecule Corrector of Trafficking-Impaired ATP-Sensitive Potassium Channels Identified in Congenital Hyperinsulinism, J Biol Chem 288:20942-20954. 17. H.M. Sampson, H. Lam, P.C. Chen, D. Zhang, C. Mottillo, M. Mirza, K. Qasim, A. Shrier, S.L. Shyng, J.W. Hanrahan, D.Y. Thomas (2013), Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines, Orphanet J Rare Dis. 8:11. 18. C. Escartin, S. Joon Won, C. Malgorn, G. Auregan G, A.E. Berman , P.C. Chen, N. Déglon, J.A. Johnson,S. Won Suh, R.A. Swanson (2011), Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino Acid transporter 3 expression, J Neurosci. 31:7392-7401. 19. P.C. Chen, C.E. Bruederle, H.Y. Gaisano, S.L. Shyng (2011), Syntaxin 1A regulates processing and endocytic trafficking of pancreatic ATP-sensitive potassium Channels, Am. J. Physiol. Cell Physiol. 300: C506-C516. 20. F.F. Yan, E.B. Pratt, P.C. Chen, F. Wang, W.R. Skach, L.L. David, S.L. Shyng (2010), Role of HSP90 in biognenesis of the β-CELL ATP-sensitive potassium channel complex, Mol. Biol. Cell. 21: 1945-1954. PMID: 20427569 21. P.C. Chen, C.L. Lao and J.C. Chen (2009), The Involvement of Cdk5 signaling in D3 dopamine receptor- mediated autoinhibition in PC-12/hD3 cells, J. Neurochem. 110: 1180-1190. PMID: 19522735 22. P.C. Chen, M.R. Vargas, A.K. Pani, R.J. Smeyne, D.A. Johnson, Y.W. Kan, and J.A. Johnson (2009), Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte, Proc. Natl. Acad. Sci. USA. 106: 2933-2938. PMID: 19196989 23. J.A. Johnson, D.A. Johnson, A.D. Kraft, M.J. Calkins, R.J. Jakel, M.R.Vargas, P.C. Chen (2009), The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration, Ann N Y Acad Sci. 1147:61-9. PMID: 19076431 24. J.C. Chen, P.C. Chen and Y.C. Chiang (2009) Molecular mechanism of psychostimulant addiction, Chang Gung Med. J. 32:148-154. PMID: 19403004 25. P.C. Chen, C.L. Lao and J.C. Chen (2006) Dual Alteration of limbic dopamine D1 receptor-mediated signaling and Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitization, J. Neurochem. 100: 225-241. PMID: 17101033 26. J.C.Chen, W.Z. Li, P.C. Chen, C.P. Tseng and Y.K. Huang (2006) Rat NPFF1 receptor-mediated signaling: functional comparison of neuropeptide FF (NPFF), FMRFamide and PFR(tic)amide, Peptides, 27:1005-1014. PMID: 16490283 27. P.C. Chen and J.C. Chen (2005) Up-regulation of Cdk5 signaling in the ventral striatum of acute and chronic methamphetamine-treated rats, Neuropsychopharmacology 30: 538-549. PMID: 15536496 28. J.C. Chen, P.C. Chen and Y.C. Chiang (2003) Dopamine D3 receptor down-regulation and functional desensitization in the olfactory tubercle of amphetamine-sensitized rats, Brain Res., 972: 159-167. PMID: 12711089 |
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