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Pei-Chun Chen

Pei-Chun Chen, Associate Professor

Pei-Chun Photo

Education and Experience:

· B.S. in Medical Technology, Chang-Gung University, 1996-2000

· Ph.D.in the Graduate Institute of Basic Medicine, Chang-Gung University, 2000-2006

·  Postdoctoral researcher in U Chicago, 2006-2007

·  Postdoctoral researcher in UW-Madison, 2007-2009

·  Postdoctoral researcher in Oregon Health and Science University , 2009-2014

·  Assistant Profession,  2014 ~2018

·  Associate Profession,  2018 ~

 

Specialty:

Neurodegenerative diseases, neuroscience, molecular biology, cell biology, potassium channel trafficking, insulin secretion related mechanism and disease

Award:

2015       “Paper of the Week” by J. Biol. Chem

2014       “Paper of the Week” by J. Biol. Chem

2013       Travel and Best Poster Awards for Postdoctoral fellows from American society of Biochemistry and Molecular Biology (ASBMB)

2011-2012   Post-doctoral Trainee, National Institute of Diabetic and Digestive and Kidney Diseases, Center Training Grant T32 DK007680

2010       Tartar Award, Oregon Health and Science University

E-mail

pcchen@mail.ncku.edu.tw

Office

82-0704 ext. 5423

Laboratory

  

82-0736 ext. 5427

Hobbies: Traveling, playing with my son, watch criminal TV shows, reading

Research interests：

Three channels that we are currently focusing on are ATP sensitive potassium channel (KATP), voltage gated potassium channel 2.1 and calcium regulated potassium channels. We study roles of these channels in diabetes, obesity, Parkinson’s disease and neural development. Example 1: we would study nervous and pancreatic systems together. Diabetes has traditionally been thought of as a peripheral metabolic disease, but the central nervous system also plays a role in regulating glucose homeostasis. The autonomic nervous system and hypothalamus-pituitary-adrenal axis both work together to regulate metabolic responses to changes in energy requirement and plasma glucose concentration. Example 2: we study these channels in the pathogenesis of Parkinson’s disease, and we are especially interested to know role of these channels in the circuit of basal ganglia.

Research approaches are included:

l   Protein trafficking, ion channel regulation and islet cell biology

l   Electrophysiology, cell and molecular biology techniques

l   Rodent experiments: stereotaxic microinjection of 6-OH-DA, subchronic MPTP model, behavioral assessments

People:

Current member

PhD students : Hao-Yeh Tsai (2024)

Master students : Yu-Chi Lin (2017), Wan-Chen Ho (2017), Liang-Chu Chang (2018), Yi-Qian You (2019), Yi-Chun Lin (2019), SIH-Yu Pan (2019), Pao-Wen Chang (2022), Pei-Yu Li (2022), Chao-Wei Huang (2022), Jue-Fang Chen (2023), Zheng-Yang Ho (2024), Chun-Kai Chiu (2024)

Former member

Master students : Kui Ming Hung (2014), Ru Yi Chao (2015), Jing-Syuna Ruan (2015), Jie-Kuan Lin (2016), Chia-Hui Cheng (2016), Yu-Chi Lin (2017), Wan-Chen Ho (2017), Liang-Chu Chang (2018), Yi-Qian You (2019), Yi-Chun Lin (2019), Sih-Yu Pan (2019)

Publication list（PubMed Link）

1.  L.C. Ho, Y. H. Chen, T.Y. Wu, L.Z. Kao, S.Y. Hung, H.H. Liou, P.C. Chen, P.J. Tsai, H.K, Lin, Y. C. Lee, H.H.  Wang, Y.S. Tsai (2023, Nov).  Phosphate burden induces vascular calcification through a NLRP3-caspase 1-mediated pyroptotic pathway. Life Sciences, 332:122123 (PMID: 37742736)

2.C. T. Lee, W. H. Tsai,  C. C. Chang,  P. C. Chen, C. S. J. Fann, H. K Chang,  S. Y. Liu, M. Z. Wu, P. C. Chiu, ,W. M. Hsu, W. S. Yang, L. P. Lai, W. Y. Tsai, S. B. Yang , P.L.  Chen (2023, Nov). Genotype-phenotype correlation in Taiwanese children with diazoxide-unresponsive congenital hyperinsulinism.  Frontiers in Endocrinology, 14:1283907 (PMID:38033998)

3.   Y.Y. Kuo, H.Y. Tsai, Y.M. Kuo, S.F. Tzeng, P.S. Chen, P. H. Hsu, Y.T. Lin, P.C. Chen* (2023, Sep). Glibenclamide promotes FGF21 secretion in interscapular BAT and attenuates depression-like behaviors in male mice with HFD-induced obesity. Life Sciences, 328:121900 (PMID:37391066)

4.    Sensitive Potassium (KATP) Channels in the Plasma Membrane Using Surface Biotinylation. Methods in molecular biology (Clifton, NJ) 1684:29-36.

5.     C.H. Lin, Y.C. Lin, SB Yang, P.C. Chen* (2022, April). Carbamazepine promotes surface expression of mutant Kir6.2-A28V ATP-sensitive potassium channels by modulating Golgi retention and autophagy. Journal of Biological Chemistry,298:101904 (PMID:35398096)

6.    H.Y. Cho, P.C. Chen, T.H. Chuang, M.C. Yu, S.N. Wu (2022, March). Activation of voltage-gated Na+ current by GV-58, a known activator of Cav channels. Biomedicines, 10:721 (PMID:35327523)

7.   H.T. Huang, P.C. Chen, P.S. Chen, W.T. Chiu, Y.M Kuo, S.F. Tzeng*. (2021, October) Inhibitory effects of trifluoperazine on peripheral proinflammatory cytokine expression and hypothalamic microglia activation in obese mice induced by chronic feeding with high-fat-diet. Front Cell Neurosci 15:752771. (PMID:34764855)

8.   Y.Y. Lam, S.F. Tsai, P.C. Chen, Y.M. Kuo, Y.W. Chen (2021, Aug). Piloglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice. Biomed Pharmacother. 140: 111734. (PMID: 34022606)

9.   Y.Y. Kuo, J.K. Lin, Y.T. Lin, J.C. Chen, Y.K. Kuo, P.S. Chen, S.N. Wu, P.C. Chen* (2020, Aug).  Glibenclamide restores dopoaminergic reward circuitry in obese mice through interscapular brown adipose tissue. Psychoneuroendocrinology, 118:104712. PMID:32479969

10.  Y.Y. Kuo, Y.C. Lin, M.J. Calkins, P.C. Chen* (2020, Aug). Endonuclease VIII-like 1 deficiency impairs survival of newly generated hippocampal neurons and memory performance in young-adult male mice. Life Sciences, 254:117755. (PMID 3247792)

11.  S.F. Tsai, H.T. Wu, P.C. Chen, Y.W. Chen, M. Yu, T.F. Wang, S.Y. Tzeng, Y.M. Kuo (2018, Dec). High-fat-die suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice. Brain Research, 1700:66-77 (PMID:30009766)

12.  J.S. Ruan, J.K. Lin, Y.Y. Kuao, Y.W. Chen, P.C. Chen* (2018, Sep). Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic beta cells. Journal of Nutritional Biochemistry, 59:37-48. (PMID: 29960115)

13.   P.C. Chen, J.S. Ruan, S.N. Wu (2018, Aug 16th). Evidence of Decreased Activity in Intermediate-Conductance Calcium-Activated Potassium Channels During Retinoic Acid-Induced Differentiation in Motor Neuron-Like NSC-34 Cells. Cell Physiology and Biochemistry, 48(6):2374-2388.

14.  S.F. Tsai, H.T. Wu, P.C. Chen, Y.W. Chen, M. Yu, S.F. Tseng, P.H. Wu, P.S. Chen, Y.M. Kuo (2018, Jul). Stress aggravates high-fat diet-induced insulin resistance via a mechanism that involves the amygdala and is associated with changes in neuroplasticity. Neuroendocrinology, 107(2), 147-157 (PMID: 29920496)

15.   R.Y. Chao, C.H. Cheng, S.N. Wu, P.C. Chen* (2018, Feb). Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration. Journal of Neurochemistry, 144 (4): 483-497. (PMID:29265365)

16.   P.C. Kuo, C.J. Yang, Y.C. Lee, P.C. Chen, Y.C. Liu, S.N. Wu (2018, Jan). The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K+ currents in insulin-secreting cells. European Journal Pharmacology, 819:233-241. (PMID 29225191)

17.   J.S Ruan, P.C. Chen* (2018). Monitoring changes in the abundance of endogenously expressed ATP sensitive potassium channels in the plasma membrane using surface biotinylation. Methods Mol Biol, 1684:29-36 (PMID:29058181)

18.  Y. Wu, D.A. Fortin, V.A. Cochrane, P.C. Chen*, S.L. Shyng* (2017, Sep). NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells. Journal of Biological Chemistry, 292 (37):15512-15524. (PMID:28768770)

19.  K.M. Hung, P.C. Chen, H. C. Hsieh, M. J Calkins (2017, Feb). Mitochondrial defects arise from nucleoside/nucleotide reverse transcriptase inhibitors in neurons: Potential contribution to HIV-associated neurocognitive disorders. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(2), p406-413. (PMID:27840304)

20.  J-I Chuang, I-L Pan, C-Y Hsieh, C-Y Huang, P.C. Chen, J W Shin (2016, Sep). Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4- phenylpyridinium treatment. Journal of Pineal Research, 61 (2):230-240. (PMID:27159033)

21.  S.F. Tsai, P.C. Chen, M. J. Calkins, S.Y. Wu and Y. M. Kuo (2016, Mar). Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle. Front. Aging Neurosci., 8:57. (PMID: 27047373)

22.         Y. Wu, S.L. Shyng, P.C. Chen* (2015, Dec). Concerted Trafficking Regulation of Kv2.1 and KATP   channels by Leptin in Pancreatic β-Cells. Journal of Biological Chemistry, 290 (50):29676-29690.  (PMID:26453299)

23.   M.H. Fu, C.L. Li, H.L. Lin, P.C. Chen, M.J. Calkins, Y.F. Chang, P.H. Cheng, S.H. Yang (2015, Oct). Stem cell transplantation therapy in Parkinson's disease. SpringerPlus, 4:597. (PMID:26543732)

24.   Q. Zhou, P.C. Chen, P.K. Devaraneni, G.M. Martin, E. Olson, S.L. Shyng (2014, Aug). Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin), 8(4):376-382. (PMID:24849284)

25.  K.M. Hung, P.C. Chen, H. C. Hsieh, M. J Calkins (2017, Feb). Mitochondrial defects arise from nucleoside/nucleotide reverse transcriptase inhibitors in neurons: Potential contribution to HIV-associated neurocognitive disorders. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(2), p406-413. (PMID:27840304)

26.  J-I Chuang, I-L Pan, C-Y Hsieh, C-Y Huang, P.C. Chen, J W Shin (2016, Sep). Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4- phenylpyridinium treatment. Journal of Pineal Research, 61 (2):230-240. (PMID:27159033)

27.   S.F. Tsai, P.C. Chen, M. J. Calkins, S.Y. Wu and Y. M. Kuo (2016, Mar). Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle. Front. Aging Neurosci., 8:57. (PMID: 27047373)

28.         Y. Wu, S.L. Shyng, P.C. Chen* (2015, Dec). Concerted Trafficking Regulation of Kv2.1 and KATP   channels by Leptin in Pancreatic β-Cells. Journal of Biological Chemistry, 290 (50):29676-29690.  (PMID:26453299)

29.  M.H. Fu, C.L. Li, H.L. Lin, P.C. Chen, M.J. Calkins, Y.F. Chang, P.H. Cheng, S.H. Yang (2015, Oct). Stem cell transplantation therapy in Parkinson's disease. SpringerPlus, 4:597. (PMID:26543732)

30.  Q. Zhou, P.C. Chen, P.K. Devaraneni, G.M. Martin, E. Olson, S.L. Shyng (2014, Aug). Carbamazepine inhibits ATP-

    sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin), 8(4):376-382.

    (PMID:24849284)

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