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Pei-Chun Chen

Pei-Chun Chen, Associate Professor

Pei-Chun Photo

Education and Experience:

· B.S. in Medical Technology, Chang-Gung University, 1996-2000

· Ph.D.in the Graduate Institute of Basic Medicine, Chang-Gung University, 2000-2006

·  Postdoctoral researcher in U Chicago, 2006-2007

·  Postdoctoral researcher in UW-Madison, 2007-2009

·  Postdoctoral researcher in Oregon Health and Science University , 2009-2014

·  Assistant Profession,  2014 ~2018

·  Associate Profession,  2018 ~

 

Specialty:

Neurodegenerative diseases, neuroscience, molecular biology, cell biology, potassium channel trafficking, insulin secretion related mechanism and disease

Award:

2015       “Paper of the Week” by J. Biol. Chem

2014       “Paper of the Week” by J. Biol. Chem

2013       Travel and Best Poster Awards for Postdoctoral fellows from American society of Biochemistry and Molecular Biology (ASBMB)

2011-2012   Post-doctoral Trainee, National Institute of Diabetic and Digestive and Kidney Diseases, Center Training Grant T32 DK007680

2010       Tartar Award, Oregon Health and Science University

E-mail

pcchen@mail.ncku.edu.tw

Office

82-0704 ext. 5423

Laboratory

82-0736 ext. 5427

Hobbies: Traveling, playing with my son, watch criminal TV shows, reading

Research interests

Three channels that we are currently focusing on are ATP sensitive potassium channel (KATP), voltage gated potassium channel 2.1 and calcium regulated potassium channels. We study roles of these channels in diabetes, obesity, Parkinson’s disease and neural development. Example 1: we would study nervous and pancreatic systems together. Diabetes has traditionally been thought of as a peripheral metabolic disease, but the central nervous system also plays a role in regulating glucose homeostasis. The autonomic nervous system and hypothalamus-pituitary-adrenal axis both work together to regulate metabolic responses to changes in energy requirement and plasma glucose concentration. Example 2: we study these channels in the pathogenesis of Parkinson’s disease, and we are especially interested to know role of these channels in the circuit of basal ganglia.

Research approaches are included:

l   Protein trafficking, ion channel regulation and islet cell biology

l   Electrophysiology, cell and molecular biology techniques

l   Rodent experiments: stereotaxic microinjection of 6-OH-DA, subchronic MPTP model, behavioral assessments

People:

Current member

 

PhD students : Yi-Ying Kuo (2018)

Master students : Yu-Chi Lin (2017), Wan-Chen Ho (2017), Liang-Chu Chang (2018), Yi-Qian You (2019), Yi-Chun Lin (2019), SIH-Yu Pan (2019)

 

Former member

 Master students : Kui Ming Hung (2014) Ru Yi Chao (2015)Jing-Syuna Ruan (2015)Jie-Kuan Lin (2016)Chia-Hui Cheng (2016)

Publication listPubMed Link

1. Ruan JS, Lin JK, Kuo YY, Chen YW, Chen PC (2018) Chronic palmitic acid-induced lipotoxicity correlates with defective trafficking of ATP sensitive potassium channels in pancreatic beta cells. The Journal of nutritional biochemistry 59:37-48.
2. Chao RY, Cheng CH, Wu SN, Chen PC (2018) Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration. 144:483-497.
3. Chen PC, Ruan JS, Wu SN (2018) Evidence of Decreased Activity in Intermediate-Conductance Calcium-Activated Potassium Channels During Retinoic Acid-Induced Differentiation in Motor Neuron-Like NSC-34 Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 48:2374-2388.
4. Tsai SF, Wu HT, Chen PC, Chen YW, Yu M, Wang TF, Wu SY, Tzeng SF, Kuo YM (2018) High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice. Brain research 1700:66-77.
5. Ruan JS, Chen PC (2018) Monitoring Changes in the Abundance of Endogenously Expressed ATP-Sensitive Potassium (KATP) Channels in the Plasma Membrane Using Surface Biotinylation. Methods in molecular biology (Clifton, NJ) 1684:29-36.
6. Tsai SF, Wu HT, Chen PC, Chen YW, Yu M, Tzeng SF, Wu PH, Chen PS, Kuo YM (2018) Stress Aggravates High-Fat-Diet-Induced Insulin Resistance via a Mechanism That Involves the Amygdala and Is Associated with Changes in Neuroplasticity. Neuroendocrinology 107:147-157.
7. Kuo PC, Yang CJ, Lee YC, Chen PC, Liu YC, Wu SN (2018) The comprehensive electrophysiological study of curcuminoids on delayed-rectifier K(+) currents in insulin-secreting cells. European journal of pharmacology 819:233-241.
8. Hung KM, Chen PC, Hsieh HC, Calkins MJ (2017) Mitochondrial defects arise from nucleoside/nucleotide reverse transcriptase inhibitors in neurons: Potential contribution to HIV-associated neurocognitive disorders. Biochimica et biophysica acta Molecular basis of disease 1863:406-413.
9. Wu Y, Fortin DA, Cochrane VA, Chen PC, Shyng SL (2017) NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic beta-cells. 292:15512-15524.
10. Tsai SF, Chen PC, Calkins MJ, Wu SY, Kuo YM (2016) Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle. Frontiers in aging neuroscience 8:57.
11. Chuang JI, Pan IL, Hsieh CY, Huang CY, Chen PC, Shin JW (2016) Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment. Journal of pineal research 61:230-240.

12. Y. Wu, S.L. Shyng, P.C. Chen (2015), Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells. J Biol Chem, 290:29676-29690. "Paper of the Week”, J Biol Chem podcast on Dec 11, 2015.

13. Q Zhou, P.C. Chen, P.K. Devaraneni, G.M. Martin, E.M Olson, S.L. Shyng, (2014) Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels, 8:376-382

14. P.C. Chen, Y. Kryukova, S.L. Shyng, (2013), Leptin regulates KATP channel trafficking in pancreatic b-cells by a signaling mechanism involving AMPK and PKA to the plasma membrane. J Biol Chem 288:34098-34109. "Paper of the Week." And A figure from the paper was selected for the Nov. 22 cover of JBC

15. G. Martin, P.C. Chen, P. Devaraneni, S.L. Shyng, (2013), Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels. Front Physiol. Dec 24;4:386. eCollection.

16. P.C. Chen , E. Olson, Q. Zhou , Y. Kryukova , H. Sampson ,D.Y. Thomas, S.L. Shyng (2013), Carbamazepine as a Novel Small Molecule Corrector of Trafficking-Impaired ATP-Sensitive Potassium Channels Identified in Congenital Hyperinsulinism, J Biol Chem 288:20942-20954.

17. H.M. Sampson, H. Lam, P.C. Chen, D. Zhang, C. Mottillo, M. Mirza, K. Qasim, A. Shrier, S.L. Shyng, J.W. Hanrahan, D.Y. Thomas (2013), Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines, Orphanet  J Rare Dis. 8:11.

18. C. Escartin, S. Joon Won, C. Malgorn, G. Auregan G, A.E. Berman , P.C. Chen, N. Déglon, J.A. Johnson,S. Won Suh, R.A.  Swanson (2011), Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino Acid transporter 3 expression, J Neurosci. 31:7392-7401.

19. P.C. Chen, C.E. Bruederle, H.Y. Gaisano, S.L. Shyng (2011), Syntaxin 1A regulates processing and endocytic trafficking of pancreatic ATP-sensitive potassium Channels, Am. J. Physiol. Cell Physiol. 300: C506-C516.

20. F.F. Yan, E.B. Pratt, P.C. Chen, F. Wang, W.R. Skach, L.L. David, S.L. Shyng (2010), Role of HSP90 in  biognenesis of the β-CELL ATP-sensitive potassium channel complex, Mol. Biol. Cell. 21: 1945-1954. PMID: 20427569

21. P.C. Chen, C.L. Lao and J.C. Chen (2009), The Involvement of Cdk5 signaling in D3 dopamine receptor- mediated autoinhibition in PC-12/hD3 cells, J. Neurochem. 110: 1180-1190. PMID: 19522735

22. P.C. Chen, M.R. Vargas, A.K. Pani, R.J. Smeyne, D.A. Johnson, Y.W. Kan, and J.A. Johnson (2009), Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte, Proc. Natl. Acad. Sci. USA. 106: 2933-2938. PMID: 19196989

23. J.A. Johnson, D.A. Johnson, A.D. Kraft, M.J. Calkins, R.J. Jakel, M.R.Vargas, P.C. Chen (2009), The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration, Ann N Y Acad Sci. 1147:61-9. PMID: 19076431

24. J.C. Chen, P.C. Chen and Y.C. Chiang (2009) Molecular mechanism of psychostimulant addiction, Chang Gung Med. J. 32:148-154. PMID: 19403004

25. P.C. Chen, C.L. Lao and J.C. Chen (2006) Dual Alteration of limbic dopamine D1 receptor-mediated signaling and Akt/GSK3 pathway in dopamine D3 receptor mutants during the development of methamphetamine sensitization, J. Neurochem. 100: 225-241. PMID: 17101033

26. J.C.Chen, W.Z. Li, P.C. Chen, C.P. Tseng and Y.K. Huang (2006) Rat NPFF1 receptor-mediated signaling: functional comparison of neuropeptide FF (NPFF), FMRFamide and PFR(tic)amide, Peptides, 27:1005-1014. PMID: 16490283

27. P.C. Chen and J.C. Chen (2005) Up-regulation of Cdk5 signaling in the ventral striatum of acute and chronic methamphetamine-treated rats, Neuropsychopharmacology 30: 538-549. PMID: 15536496

28. J.C. Chen, P.C. Chen and Y.C. Chiang (2003) Dopamine D3 receptor down-regulation and functional desensitization in the olfactory tubercle of amphetamine-sensitized rats, Brain Res., 972: 159-167. PMID: 12711089

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