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Hung-Yu Sun

Hung-Yu Sun, Assistant professor

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Education and Experience:

B.S., Department of Zoology, National Chung Hsing University, 1998-2002

M.S., Institute of Molecular Medicine, National Cheng Kung University, 2002-2004

Ph.D., Institute of Basic Medical Sciences, National Cheng Kung University, 2004-2011

Postdoctoral Fellow, National Cheng Kung University, 2012-2018

Visiting Postdoctoral Fellow, University of Ottawa, 2016-2016

Adjunct Assistant Professor, Institute of Molecular Medicine, National Cheng Kung University, 2018-2022

Professor, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 2018-2022

Assistant Professor, Department of Physiology, National Cheng Kung University, 2018-now

Specialty:

Lipoprotein physiology; Non-alcoholic liver disease; Host metabolism and virus infection; Viral pathogenesis

Award:

2017. Outstanding Academic Paper Award, Liver Disease Prevention & Treatment Research Foundation, Taiwan

2013. Postdoctoral Fellow Outstanding Publication Awards, National Science Council of Taiwan

2012. The Prize in Oral presentation, The 20th Annual Meeting of the Taiwan Society of Microbiology (virology), Taiwan Society of Microbiology

2011. Professor Zhi-Zhong Yan Scholar Award, Taiwan Society of Microbiology, Taiwan

E-mail

z11108042@ncku.edu.tw; s5893149@gmail.com

Office

82-0705 ext. 5420

Laboratory

 

Hobbies: Jogging, Backpacking, Travel, Workout

Research interests：

1.Investigate the role of apolipoproteins in metabolic disorder and viral infection.

2.Study the function of stress-induced Apolipoprotein J chaperone on lipid metabolism.

3.Develop lipid-lowing peptide to relieve aberrant lipid accumulation.

Lab website:

People:

Current member

Ph.D student: 

Ms.D student:

Assistant：

Former member

Ph.D student: 

Ms.D student:

Publication list（PubMed Link）

Papers(2017-2022)

  1. Cong Wang, Xue Li, Changping Yu, Luoling Wang, Rilin Deng, Yan Xu, Renyun Tian, Shengwen Wen, Hui Liu, Zihao Chen, yingdan zhang, Hungyu Sun, Haizhen Zhu, Jianli Wang, Songqing Tang. RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth. Nature Communications. (Under review)
  2. Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Yen-Cheng Chiu, Sin-Tian Wang, Dyoness Charmaine Tan, Hung-Chih Chiu1, Shih-Chih Chien, Kung-Chia Young. Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. J Microbiol Immunol Infect. S1684-1182(22)00095-0 (Co-first author)
  3. Shu-Fang Hsieh, Hung-Yu Sun, Sin-Tian Wan, Sin-Syue Li, Ya-Ting Hsu, Kung-Chia Young. Plasma lipid profiling increased cardiometabolic risks in acute myeloid leukaemia patients pre- and postchemotherapy. J. Biomed. Lab. Sci. 2022;34(2).
  4. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Sterol O-acyltransferase 2 chaperoned by Apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses. Commun Biol. 2021;4(1):564.
  5. Li Y, Wang X, Han Y, Sun HY, Hilborn J, Shi L. Click chemistry-based biopolymeric hydrogels for regenerative medicine. Biomed Mater. 2021;16;16(2):022003.
  6. Pinals RL, Ledesma F, Yang D, Navarro N, Jeong S, Pak JE, Kuo L, Chuang YC, Cheng YW, Sun HY, Landry MP. Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors. Nano Lett. 2021;10;21(5):2272-2280.
  7. Tsai P, Lin TY, Cheng SL, Sun HY, Chen SF, Young KC. Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection. J Microbiol Immunol Infect. 2020;53(5):715-723.
  8. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chang HA, Chong LW, Chang HC, Young KC, Bai CH, Tsao CW. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation. Biomed Res Int. 2019; 3102414.
  9. Wang MY, Huang HY, Kuo YL, Lo C, Sun HY, Lyu YJ, Chen BR, Li JN, Chen PS. TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer. Cancers (Basel). 2019;11(2):210.
  10. Lai HH, Li CW, Hong CC, Sun HY, Chiu CF, Ou DL, Chen PS. TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Mol Oncol. 2019;13(4):928-945.
  11. Tsai P, Lin CC, Sun HY, Lee JC, Chang TT, Young KC. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia. J Microbiol Immunol Infect. 2018;51(4):446-455.
  12. Sun HY, Cheng PN, Tseng CY, Tsai WJ, Chiu YC, Young KC. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018;67(7):1342-1350.
  13. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chong LW, Chang HC, Bai CH, Young KC, Tsao CW. Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses. 2018;10(2):57.
  14. Sun HY, Lin CC, Tsai PJ, Tsai WJ, Lee JC, Tsao CW, Cheng PN, Wu IC, Chiu YC, Chang TT, Young KC. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cell Microbiol. 2017;19(4):e12673.

Patent

2021, 一種應用於抑制細胞內脂質積累的多肽及其合成方法，發明人: 孫宏羽(1)、秦儂(2)、莊詠鈞(3)、鄭又瑋(4) (Patent No. ZL 2021 1 0245720.4, 已授權)

CONFERENCE PAPERS (2017-2022)

  1. Sin-Tian Wang, Tzu-Ying Chen, Hung-Yu Sun*, Kung-Chia Young*.  Apolipoprotein J-chaperoned sterol O-acyltransferase 2 induces steatosis with hepatitis C virus infection. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  2. Sin-Tian Wang, Pin-Nan Cheng, I-Che Feng, Hung-Yu Sun*, Kung-Chia Young*. Post-therapeutic interdependence of long-term glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  3. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-mediated sterol O-acyltransferase activation facilitates hepatic lipid accumulation induced by hepatitis C virus infection. 27th International Symposium on Hepatitis C Virus and Related Viruses, Virtual meeting. 2021, Jul. 06-09. 
  4. Duan Shuangdi, Gao Yating, Pi Jiayi, Qin Nong, Sun Hung-Yu*. Apolipoprotein J induced hepatic lipid deposition via impairing lipophagy. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  5. Hung-Yu Sun*, Tzu-Ying Chen, Shuang-Di Duan, Nong Qin, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-chaperoned sterol O-acyltransferase 2 facilitates stress-induction of hepatic lipid accumulation. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  6. Hung-Yu Sun, Tzu-Ying Chen, Kung-Chia Young. The role of apolipoprotein J in HCV-dysregulated intracellular cholesterol homeostasis. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  7. Dyoness Charmaine Tan, Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. The roles of lipoprotein/apolipoprotein in HCV-induced lipid accumulation, cellular senescence and DNA repair. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  8. Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on the roles of lipoprotein/apolipoprotein in lipid accumulation, cellular senescence and DNA repair. International Symposiums on Immunity and Infection, Tainan, Taiwan (R.O.C), 2018, Oct. 19-20.
  9. Tzu-Ying Chen, Hung-Yu Sun, Yu-Ching Tan, Kung-Chia Young. Study on the role of apolipoprotein J in aberrant lipid accumulation with hepatitis C virus infection. 25th International Symposium on Hepatitis C Virus and Related Viruses, Dublin, Ireland, 2018, Oct. 08-11.
  10. Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on apolipoprotein J-mediated lipid accumulation in hepatocytes and macrophages. International Symposium on Major Southeast Asia Infectious Diseases, Taiwan-Japan Joint, Tainan, Taiwan (R.O.C), 2017, Nov. 11-12.

Laboratory View

Laboratory activities