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Hung-Yu Sun

Hung-Yu Sun, Assistant professor

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Education and Experience:

B.S., Department of Zoology, National Chung Hsing University, 1998-2002

M.S., Institute of Molecular Medicine, National Cheng Kung University, 2002-2004

Ph.D., Institute of Basic Medical Sciences, National Cheng Kung University, 2004-2011

Postdoctoral Fellow, National Cheng Kung University, 2012-2018

Visiting Postdoctoral Fellow, University of Ottawa, 2016-2016

Adjunct Assistant Professor, Institute of Molecular Medicine, National Cheng Kung University, 2018-2022

Professor, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 2018-2022

Assistant Professor, Department of Physiology, National Cheng Kung University, 2018-now

Specialty:

Lipoprotein physiology; Non-alcoholic liver disease; Host metabolism and virus infection; Viral pathogenesis

Award:

2023. Young Scholar’s Innovation R&D Outstanding Award

2023. Best oral presentation award, The 32nd Conference of the Asian Pacific Association for the Study of the Liver

2017. Outstanding Academic Paper Award, Liver Disease Prevention & Treatment Research Foundation, Taiwan

2013. Postdoctoral Fellow Outstanding Publication Awards, National Science Council of Taiwan

2012. The Prize in Oral presentation, The 20th Annual Meeting of the Taiwan Society of Microbiology (virology), Taiwan Society of Microbiology

2011. Professor Zhi-Zhong Yan Scholar Award, Taiwan Society of Microbiology, Taiwan

E-mail

husun@gs.ncku.edu.tw

Office

82-0716 ext. 5457

Laboratory

82-0557 ext. 5320

Hobbies: Jogging, Backpacking, Travel, Workout

Research interests：

1.Investigate the role of apolipoproteins in metabolic disorder and viral infection.

2.Study the function of stress-induced Apolipoprotein J chaperone on lipid metabolism.

3.Develop lipid-lowing peptide to relieve aberrant lipid accumulation.

Lab website:

People:

Current member

Ph.D student: 

Ms.D student: Mei-Chi Huang, Ya-Wen Chang, Yong-Han Ke, Yu-Ting Hsu

Assistant：Li-Chi Chi, Hsin-Tzu Wang

Former member

Ph.D student: Shuangdi Duan,

Ms.D student: Jiayi Pi, Yating Gao, Nong Qin, Pei Sun, Wei-Zuo Chen, Hsin-Tzu Wang

Publication list（PubMed Link）

Papers(2017-2024)

  1. Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, Yating Gao, Lamei Liu, Zenghui Li, Ya Li, Liyang Shi, Qiang Gao, Ye Qiu, Songqing Tan, Chun-Hsiang Wang, Tzu-Ying Chen, Sin-Tian Wang, Kung-Chia Young, Hung-Yu Sun*. Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition. Hepatology, 2023; 78(4):1182-1199.
  2. Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Sin-Tian Wang, Yen-Cheng Chiu, Hung-Chih Chiu, Shih-Chieh Chien, Kung-Chia Young. Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents. J Virus Erad. 2023;9(1):100318.
  3. Shuangdi Duan, Jiayi Pi, Chun-Hsiang Wang, Yi-Chou Hou, Chung-Ying Andy Lee, Cheng-Jui Lin, Liyang Shi, Kung-Chia Young, Hung-Yu Sun*. Assessment of ELISA-based method for the routine examination of serum indoxyl sulfate in patients with chronic kidney disease. Heliyon. 2022;8(12):e12220.
  4. Cong Wang, Xue Li, Changping Yu, Luoling Wang, Rilin Deng, Yan Xu, Renyun Tian, Shengwen Wen, Hui Liu, Zihao Chen, yingdan zhang, Hungyu Sun, Haizhen Zhu, Jianli Wang, Songqing Tang. RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth. Nature Communications. (Under review)
  5. Pin-Nan Cheng, Hung-Yu Sun, I-Che Feng, Yen-Cheng Chiu, Sin-Tian Wang, Dyoness Charmaine Tan, Hung-Chih Chiu1, Shih-Chih Chien, Kung-Chia Young. Interdependence of glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. J Microbiol Immunol Infect. S1684-1182(22)00095-0 (Co-first author)
  6. Shu-Fang Hsieh, Hung-Yu Sun, Sin-Tian Wan, Sin-Syue Li, Ya-Ting Hsu, Kung-Chia Young. Plasma lipid profiling increased cardiometabolic risks in acute myeloid leukaemia patients pre- and postchemotherapy. J. Biomed. Lab. Sci. 2022;34(2).
  7. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Sterol O-acyltransferase 2 chaperoned by Apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses. Commun Biol. 2021;4(1):564.
  8. Li Y, Wang X, Han Y, Sun HY, Hilborn J, Shi L. Click chemistry-based biopolymeric hydrogels for regenerative medicine. Biomed Mater. 2021;16;16(2):022003.
  9. Pinals RL, Ledesma F, Yang D, Navarro N, Jeong S, Pak JE, Kuo L, Chuang YC, Cheng YW, Sun HY, Landry MP. Rapid SARS-CoV-2 Spike Protein Detection by Carbon Nanotube-Based Near-Infrared Nanosensors. Nano Lett. 2021;10;21(5):2272-2280.
  10. Tsai P, Lin TY, Cheng SL, Sun HY, Chen SF, Young KC. Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection. J Microbiol Immunol Infect. 2020;53(5):715-723.
  11. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chang HA, Chong LW, Chang HC, Young KC, Bai CH, Tsao CW. Etifoxine, a TSPO Ligand, Worsens Hepatitis C-Related Insulin Resistance but Relieves Lipid Accumulation. Biomed Res Int. 2019; 3102414.
  12. Wang MY, Huang HY, Kuo YL, Lo C, Sun HY, Lyu YJ, Chen BR, Li JN, Chen PS. TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer. Cancers (Basel). 2019;11(2):210.
  13. Lai HH, Li CW, Hong CC, Sun HY, Chiu CF, Ou DL, Chen PS. TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Mol Oncol. 2019;13(4):928-945.
  14. Tsai P, Lin CC, Sun HY, Lee JC, Chang TT, Young KC. Viral dynamics of persistent hepatitis C virus infection in high-sensitive reporter cells resemble patient's viremia. J Microbiol Immunol Infect. 2018;51(4):446-455.
  15. Sun HY, Cheng PN, Tseng CY, Tsai WJ, Chiu YC, Young KC. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018;67(7):1342-1350.
  16. Lin YM, Sun HY, Chiu WT, Su HC, Chien YC, Chong LW, Chang HC, Bai CH, Young KC, Tsao CW. Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation. Viruses. 2018;10(2):57.
  17. Sun HY, Lin CC, Tsai PJ, Tsai WJ, Lee JC, Tsao CW, Cheng PN, Wu IC, Chiu YC, Chang TT, Young KC. Lipoprotein lipase liberates free fatty acids to inhibit HCV infection and prevent hepatic lipid accumulation. Cell Microbiol. 2017;19(4):e12673.

Patent

 

2024, OPTIMIZING LIPID AND GLYCEMIC HOMEOSTASIS THROUGH THERAPEUTIC PEPTIDE NAVIGATION, 發明人: 1.楊孔嘉；2.孫宏羽 美國(申請號 63/659,956)

2024, POLYPEPTIDE APPLIED TO INHIBITION OF INTRACELLULAR LIPID ACCUMULATION AND SYNTHESIS METHOD THEREOF，發明人: 孫宏羽(1)、秦儂(2)、莊詠鈞(3)、鄭又瑋(4)、段雙迪(5)、高雅廷(6)、楊孔嘉(7)，美國(申請號 18/576,106)

2024, MK52用於製備促進脂質分解作用及減緩相關症候群之醫藥組成物的用途,發明人: 孫宏羽(1)、楊孔嘉(2) (台灣發明專利申請號 112150571)

2023, 一種用於緩解代謝症候群發展的載脂蛋白J拮抗肽,發明人: 孫宏羽(1)、陳百昇(2)、楊孔嘉(3) (美國臨時案申請號：63/384,953)

2021, 一種應用於抑制細胞內脂質積累的多肽及其合成方法，發明人: 孫宏羽(1)、秦儂(2)、莊詠鈞(3)、鄭又瑋(4) (Patent No. ZL 2021 1 0245720.4, 已授權)

CONFERENCE PAPERS (2017-2024)

  1. Hsin-Tzu Wang, Mei-Ling Cheng, Chi-Jen Lo, Hung-Yu Sun*. Reactivation of bile acid alternative pathway rebalances cholesterol homeostasis and relieves metabolic-associated fatty liver disease. APASL Single Topic Conference on Metabolic Associated Fatty Liver Disease (MAFLD), Kaohsiung, Taiwan, 2024, Jun. 28-30
  2. Hung-Yu Sun*. Apolipoprotein J facilitates diabetic nephropathy progression via mTOR-TFEB-autophagy axis. The 33rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2024), Kyoto, Japan, 2024, Mar. 27-31. (Oral presentation)
  3. Wei-Zuo Chen, Hung-Yu Sun*. Investigating the Interactome of Apolipoprotein J under Lipid Stress. The 33rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2024), Kyoto, Japan, 2024, Mar. 27-31. (Corresponding author)
  4. Hsin-Tzu Wang, Hung-Yu Sun*. Targeting Apolipoprotein J restores hepatic cholesterol balance via bile acid alternative pathway. The 33rd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2024), Kyoto, Japan, 2024, Mar. 27-31. (Corresponding author)
  5. Shuang-di Duan, Hung-Yu Sun*. Apolipoprotein J Accumulation in Renal Tubules Contributes to Pathogenesis of Diabetic Nephropathy. 10th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2023). Daegu, Korea, 2023, Nov. 1-4. (Samyang Best Research Award)
  6. Jiayi Pi, Hung-Yu Sun*. Apolipoprotein J facilitates indoxyl sulfate-induced activation of AhR and promotes the progression of chronic kidney disease. 10th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS 2023). Daegu, Korea, 2023, Nov. 1-4.
  7. Mei-Chi Huang, Jia-Yi Pi, Hung-Yu Sun*. Apolipoprotein J facilitates indoxyl sulfate-mediated impairment of mitophagy in renal epithelial cell. Taiwan Society for Mitochondrial Research and Medicine: DiscoverMITO in Human Diseases. Tainan, Taiwan, 2023, Oct. 28
  8. Shuang-di Duan, Nong Qin, Jia-I Pi, Pei Sun, Hsin-Tzu Wang, Hung-Yu Sun*. Hepatic Apolipoprotein J facilitates metabolic disease progression by promoting mTOR-mediated suppression of autophagy. EASL Congress 2023, Vienna, Austria, 2023, Jun. 21-24. (Registration bursary Awards)
  9. Hsin-Tzu Wang, Shuang-di Duan, Nong Qin, Jia-I Pi, Pei Sun, Hung-Yu Sun*. Targeting Apolipoprotein J restores autophagy and improves metabolic-associated fatty liver disease and diabetic nephropathy. EASL Congress 2023, Vienna, Austria, 2023, Jun. 21-24. (Full Bursary Awards)
  10. Hung-Yu Sun*, Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, Hsin-Tzu Wang. Targeting Apolipoprotein J chaperone activity relieves hepatic steatosis through facilitating proteasomal degradation of mTOR. The 32nd Conference of the Asian Pacific Association for the Study of the Liver (APASL 2023), Taipei, Taiwan, 2023, Feb. 15-19. (Corresponding author) (Best oral presentation award)
  11. Yi-Chou Hou, Hung-Yu Sun*. Identification of ELISA-based methods for the routine examination of serum indoxyl sulfate levels in CKD patients. 2022 Annual Meeting of Taiwan Society of Nephrology, Taipei, Taiwan, 2022, Dec. 10-11. (Corresponding author)
  12. Hung-Yu Sun*, Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun. Apolipoprotein J chaperones mTOR to suppress lipophagy and facilitate hepatic lipid deposition. 14th International Congress of Cell Biology & 9th Asian Pacific Organization for Cell Biology. Taipei, Taiwan, 2022, Nov. 07-11. (Short talk) (Corresponding author)
  13. Sin-Tian Wang, Tzu-Ying Chen, Hung-Yu Sun*, Kung-Chia Young*.  Apolipoprotein J-chaperoned sterol O-acyltransferase 2 induces steatosis with hepatitis C virus infection. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  14. Sin-Tian Wang, Pin-Nan Cheng, I-Che Feng, Hung-Yu Sun*, Kung-Chia Young*. Post-therapeutic interdependence of long-term glycemic and lipid modulation in cured chronic hepatitis C patients by direct-acting antiviral agents. Taiwan Society of Microbiology 2021 annual meeting and symposium. Taipei, Taiwan, 2021, Dec. 04-05. (Co-corresponding author)
  15. Hung-Yu Sun, Tzu-Ying Chen, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-mediated sterol O-acyltransferase activation facilitates hepatic lipid accumulation induced by hepatitis C virus infection. 27th International Symposium on Hepatitis C Virus and Related Viruses, Virtual meeting. 2021, Jul. 06-09. 
  16. Duan Shuangdi, Gao Yating, Pi Jiayi, Qin Nong, Sun Hung-Yu*. Apolipoprotein J induced hepatic lipid deposition via impairing lipophagy. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  17. Hung-Yu Sun*, Tzu-Ying Chen, Shuang-Di Duan, Nong Qin, Yu-Ching Tan, Chun-Hsiang Wang, Kung-Chia Young. Apolipoprotein J-chaperoned sterol O-acyltransferase 2 facilitates stress-induction of hepatic lipid accumulation. 2021 Annual Meeting of Chinese Society for Cell Biology, Chungking, China, 2021, Apr. 13-16. (Corresponding author)
  18. Hung-Yu Sun, Tzu-Ying Chen, Kung-Chia Young. The role of apolipoprotein J in HCV-dysregulated intracellular cholesterol homeostasis. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  19. Dyoness Charmaine Tan, Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. The roles of lipoprotein/apolipoprotein in HCV-induced lipid accumulation, cellular senescence and DNA repair. 26th International Symposium on Hepatitis C Virus and Related Viruses. Seoul, South Korea. 2019, Oct. 05-08.
  20. Yu-Ching Tan, Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on the roles of lipoprotein/apolipoprotein in lipid accumulation, cellular senescence and DNA repair. International Symposiums on Immunity and Infection, Tainan, Taiwan (R.O.C), 2018, Oct. 19-20.
  21. Tzu-Ying Chen, Hung-Yu Sun, Yu-Ching Tan, Kung-Chia Young. Study on the role of apolipoprotein J in aberrant lipid accumulation with hepatitis C virus infection. 25th International Symposium on Hepatitis C Virus and Related Viruses, Dublin, Ireland, 2018, Oct. 08-11.
  22. Tzu-Ying Chen, Hung-Yu Sun, Kung-Chia Young. Study on apolipoprotein J-mediated lipid accumulation in hepatocytes and macrophages. International Symposium on Major Southeast Asia Infectious Diseases, Taiwan-Japan Joint, Tainan, Taiwan (R.O.C), 2017, Nov. 11-12.

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Laboratory activities