Yuan-Yu (Ben) Hsueh   Associate Professor

Education and Experience:

Education:

PhD, Institute of Clinical Medicine, National Cheng Kung University 2011-2015

MSc, Institute of Clinical Medicine, National Cheng Kung University 2007-2010

MD, College of Medicine, National Cheng Kung University 1996-2003

Experience:

• Attending Physician in Plastic Surgery, National Cheng Kung University Hospital 2009~present
• Clinical Associate Professor of Surgery, National Cheng Kung University 2021-2024
• Visiting Research Scholar, Department of Bioengineering, UCLA, USA 2017-2019
• Clinical Assistant Professor of Surgery, National Cheng Kung University 2015-2021
• Visiting Scholar, Department of Plastic Surgery, Tokyo University, 2014
• Resident of Plastic Surgery, National Cheng Kung University Hospital 2003-2009

Specialty:

Clinical Specialty

1. Hand surgery: hand trauma, finger reconnection, peripheral nerve surgery, tendon surgery, nerve stimulation

2. Scar reshaping: treatment of keloid and hypertrophic scars, scar revision surgery, scar shaping and repair

3. Body sculpting surgery: liposuction, autologous fat grafting

4. Cell therapy: autologous adipose stem cell regeneration therapy

Award:

• 2024 International Inventor Prize, International Academia/ Innovation Award (學術國光獎章) (2024/10)
• 2024 Taiwan Innovation Award, Innovative Improvement Award (2024/10)
• 2023 Taiwan Innovation Award, Innovative Improvement Award (2023/11)
• 2023 Taiwan Innovation Award, Academic Research Innovation Award (2023/10)
• 2023 Young Scholars' Innovative R&D Results Selection Award Ceremony (台綜大「年輕學者創新研發成果選拔」生醫領域－優等獎) (2023/10)
• 2023 FutureTech Award (未來科技獎-生技新藥與醫材領域) (2023/08)
• 2023 Macronix Golden Silicon Awards, Semiconductor Design and Application Competition - Best Creative Advisor Professor (2023/07)
• 2023 Macronix Golden Silicon Awards, Best Advisor Award (2023/07)
• 2023 National Innovation Award Academic Research Innovation Award (2022/08)
• National Cheng Kung University Hospital, 2021 High Impact Journal Award (2022/02)
• Cheng-Hsing Medical Foundation, 2021 Outstanding Paper Award (2021/12)
• National Cheng Kung University, College of Medicine, 2014 Best Young Investigator Award (2016/04)
• Honorary member of the Phi Tau Phi Scholastic Honor Society of the Republic of China(2015/06)
• 2014 National Cheng Kung University Hospital Medical Research Grant Poster Competition: Award for Excellent (2014/12)
• National Cheng Kung University Medical College PhD student Oral Paper Competition:  Outstanding Research Award (2014/06)
• Taiwan Association of Regenerative Medicine Oral Paper Competition： 1st Prize(2014/02)
• TIGP-NCKU Neuroscience Retreat, Travel Grant Competition： 2nd Prize (2014/01)
• Taiwan Association of Regenerative Medicine Oral Paper Competition： Award for Excellent (2012/02)
• 2010 National Cheng Kung University Hospital Medical Research Grant Poster Competition: 3rd Prize (2010/12)

E-mail

yyhsueh@mail.ncku.edu.tw

Office

82-0719 ext. 5460

Laboratory

82-0754 ext. 5447

Hobbies: Traveling, camping, and reading

Research interests：

1. Regenerative medicine: peripheral nerve regeneration, electrical stimulation, neuromodulation, wound healing

    and  tissue regeneration, flap angiogenesis

2. Scar research: pathogenesis and treatment of keloids and hypertrophic scars

3. Stem cell research: adipose stem cells, neural stem cells, vascular stem cells

4. Medical device development: electrical stimulator, pain modulator, AIoT

People:

Current member

RESEARCH SCIENTIST

Szu-Han (Stanley) Chen, MD, MSc, PhD

Shun-Ho Huang, PhD

Kuo-Shu Hung, MD, MSc

Wan-Ling Tseng, MD, MSc

PhD STUDENT

Tzu-Chun Chung, MD

Yi-Syuan (Sherry) Shin, MD

CLINICAL FELLOW

Ming-Wei Hsu, MD

Yu-Wen Lin, MD

UNDERGRADUATE STUDENT

Chun-Wei Lin

Sung-Chun Hsieh

Po-Liang Ou

RESEARCH ASSISTANT

Chen-Hsing Lin (Daisy)

Nancy Lee

Li-Yu Chiou (Fiona)

Yu-Ting Ou (Miko)

Publication list（PubMed Lik）

1. Yi-Syuan Shin#, Kuo-Shu Hung, Chung-Te Tsai, Meng-Hsuan Wu, Chih-Lung Lin, Yuan-Yu Hsueh*. Validation of multispectral imaging-based tissue oxygen saturation detecting system for wound healing recognition on open wounds. Journal of Biomedical Optics, 2024 Aug 29(8):086004-1~13
2. Szu-Han Chen#, Yu-Wen Lin#, Wan-Ling Tseng, Wei-Tso Lin, Sheng-Che Lin, Yuan-Yu Hsueh*. Ultrahigh frequency transcutaneous electrical nerve stimulation for neuropathic pain alleviation and neuromodulation. Neurotherapeutics 2024 Feb 16;21(3):e00336. doi: 10.1016/j.neurot.2024.e00336.
3. Jyun-Yuan Huang, Tzyy-Yue Wong, Ting-Yuan Tu, Ming-Jer Tang, Hsi-Hui Lin, Yuan-Yu Hsueh*. Assessment of Tilapia Skin Collagen for Biomedical Research Applications in Comparison with Mammalian Collagen. Molecules. 2024 Jan 13;29(2):402.
4. Chia-Bao Chu, Chao-Chun Yang, Yuan-Yu Hsueh, Po-Chuan Chen, Yi-Kai Hong, Yu-Yun Kuo, Shaw-Jenq Tsai. Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa. Br J Dermatol. 2023Aug 4;ljad273. doi: 10.1093/bjd/ljad273IF: 11.0 Q1
5. Szu-Han Chen#, Chia-Ching Wu, Wan-Ling Tseng, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Sheng-Che Lin , Yuan-Yu Hsueh*. Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve. Front Neurosci. 2023 Jun 29;17:1172740
6. Ming-Wei Hsu#, Szu-Han Chen, Wan-Ling Tseng, Kuo-Shu Hung, Tzu-Chun Chung, Sheng-Che Lin, Jahyun Koo and Yuan-Yu Hsueh*. Physical processing for decellularized nerve xenograft in peripheral nerve regeneration. Front. Bioeng. Biotechnol. 2023 May 30; 11:1217067. doi: 10.3389/fbioe.2023.1217067
7. Meng-Wei Lin, Yu-Tzu Chang, Yuan-Yu Hsueh*, Hyperosmolar Hyperglycemic Crisis  After Burn Injury in a Patient With Advanced Amyotrophic Lateral Sclerosis: A  Case Report. Annals of Plastic Surgery 2022 Oct 1;89(4):373-375
8. Woo-Youl Maeng, Wan-Ling Tseng#, Song Li, Jahyun Koo, Yuan-Yu Hsueh*. Electroceuticals for peripheral nerve regeneration. Biofabrication 2022 Sep;14(4): 042002-042021
9. Anjali Yadav, Thamil Selvee Ramasamy, Sheng-Che Lin, Szu-Han Chen, Jean Lu, Ya-Hsin Liu, Fu-I Lu, Yuan-Yu Hsueh, Shau-Ping Lin, Chia-Ching Wu. Autologous Platelet-Rich Growth Factor Reduces M1 Macrophages and Modulates Inflammatory Microenvironments to Promote Sciatic Nerve Regeneration Biomedicines. 2022 Aug 17;10(8):1991.
10. Wei-Yu Tsai, Yuan-Yu Hsueh, Pei-Yu Chen, Kuo-Shu Hung, Chih-Chung Huang. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jun;69(6):1871-1880
11. LeeAnn K. Li, Wen‑Chin Huang, Yuan‑Yu Hsueh, Ken Yamauchi, Natalie Olivares, Raul Davila, Jun Fang, Xili Ding, Weikang Zhao, Jennifer Soto, Mahdi Hasani, Bennett Novitch and Song Li. Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury. Stem Cell Research & Therapy 2022 May 16;13(1):205-218.
12. Anjali Yadav, Tzu-Chieh Huang, Szu-Han Chen, Thamil Selvee Ramasamy, Yuan-Yu Hsueh, Shau-Ping Lin , Fu-I Lu, Ya-Hsin Liu, Chia-Ching Wu. Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination. Journal of Neuroinflammation 2021; 18(1):238-253.
13. An Huang, Yi-Shiuan Lin, Ling-Zhen Kao, Yu-Wei Chiou, Gang-Hui Lee, Hsi-Hui Lin, Chih-Hsing Wu, Chin-Sung Chang, Kuo-Ting Lee, Yuan-Yu Hsueh, Pei-Jane Tsai, Ming-Jer Tang, Yau-Sheng Tsai. Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity. Clinical Translational Medicine. 2021 Sep;11(9):e543. doi: 10.1002/ctm2.543IF: 7.9 Q1
14. Szu-Han Chen#, Chia-Ching Wu, Sheng-Che Lin, Wan-Ling Tseng, Tzu-Chieh Huang, Anjali Yadav, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Yuan-Yu Hsueh* Investigation of neuropathology after nerve release in chronic constriction injury of rat sciatic nerve. International Journal of Molecular Sciences 2021; 22(9):4746-4763
15. Yeu-Her Lai, Li-Wen Chen, Yuan-Yu Hsueh* Delayed neurological sequelae in an infant after carbon monoxide intoxication. Journal of Burn Care and Research 2021 Apr 23:irab074. doi: 10.1093/jbcr/irab074IF: 1.5 Q3
16. Jun Fang, Junren Sia, Jennifer Soto, Pingping Wang, LeeAnn K Li, Yuan-Yu Hsueh, Raymond Sun, Kym Francis Faull, James G Tidball, Song Li, Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nature Biomedical Engineering 2021 Aug;5(8):864-879; doi: 10.1038/s41551-021-00696-y
17. Yeon Sik Choi, Yuan-Yu Hsueh, Jahyun Koo, Quansan Yang, Buwei Hu, Zhaoqian Xie, Raudel Avila, Geumbee Lee, Ning Zheng, Claire Liu, Yameng Xu, Young Joong Lee, Weikan Zhao, Jun Fang, Yujun Deng, Seung Min Lee, Iwona Stepien, Ying Yan, Joseph Song, Chad Haney, Yong Suk Oh, Wentai Liu, Hong-Joon Yoon, Anthony Banks, Matthew MacEwan, Guillermo Ameer, Wilson Ray, Yonggang Huang ,Colin Franz, Tao Xie, Song Li, Abraham Vazquez-Guardado, John A. Rogers. Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration. Nature Communications 2020 Nov; 11(1):5990-6003
18. Chen SH, Huang TC, Wang JY, Wu CC, Hsueh YY*. Controllable forces for reproducible chronic constriction injury mimicking compressive neuropathy in rat sciatic nerve. J Neurosci Methods. 2020 Apr; 335:108615.
19. Huang CW, Lu SY, Huang TC, Huang BM, Sun HS, Yang SH, Chuang JI, Hsueh YY, Wu YT, Wu CC. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics. 2020 Feb; 10(6):2817-2831.
20. Fang J, Hsueh YY, Soto J, Sun W, Wang J, Gu Z, Khademhosseini A, Li S. Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming. ACS Nano. 2020 Feb; 14(2):1296-1318.
21. Huang CW, Hsueh YY, Huang WC, Patel S, Li S. Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. Stem Cell Res Ther. 2019 Aug; 10(1):234.
22. Chang TY, Hsueh YY, Yen YT, Lee JW. Factors affecting functional outcomes following mangled lower limb injury. Asian J Surg. 2019 May.; 42(5):644-646.
23. Lin CH, Chiu PY, Hsueh YY, Shieh SJ, Wu CC, Wong TW, Chuong CM, Hughes MW.  Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing. Exp Dermatol. 2019 Apr.; 28(4):472-479.
24. Hsueh WT, Hung KS, Chen YC, Huang YT, Hsu CK, Ogawa R, Hsueh YY*.  Adjuvant Radiotherapy After Keloid Excision: Preliminary Experience in Taiwan.  Ann Plast Surg. 2019 Jan.; 82(1S Suppl 1):S39-S44.
25. Chang TY, Lee YC, Lin YC, Wong ST, Hsueh YY, Kuo YL, Shieh SJ, Lee JW. Implantable Doppler Probes for Postoperatively Monitoring Free Flaps: Efficacy. A Systematic Review and Meta-analysis. Plast Reconstr Surg Glob Open. 2016 Nov; 4(11):e1099
26. Huang CF, Chang YJ, Hsueh YY, Huang CW, Wang DH, Huang TC, Wu YT, Su FC, Hughes M, Chuong CM, Wu CC. Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction. Sci Rep. 2016 May; 6:26436.
27. Hsueh YY#, Wang DH, Huang TC, Chang YJ, Shao WC, Tuan TL, Hughes MW, Wu CC. Novel skin chamber for rat ischemic flap studies in regenerative wound repair. Stem Cell Res Ther. 2016 May; 7(1):72.
28. Chang YJ, Huang HC, Hsueh YY, Wang SW, Su FC, Chang CH, Tang MJ, Li YS, Wang SH, Shung KK, Chien S, Wu CC. Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention. Sci Rep. 2016 Feb; 6:22147.
29. Huang CW, Huang CC, Chen YL, Fan SC, Hsueh YY, Ho CJ, Wu CC. Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling.  Biomed Res Int. 2015 Oct.; 862485.
30. Hsueh YY#, Chang YJ, Huang CW, Handayani F, Chiang YL, Fan SC, Ho CJ, Kuo YM, Yang SH, Chen YL, Lin SC, Huang CC, Wu CC. Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury. Sci Rep. 2015 Oct; 5:14985.
31. Chang TY, Pan SC, Huang YH, Hsueh YY *. Blindness after calcium hydroxylapatite injection at nose. J Plast Reconstr Aesthet Surg. 2014 Dec; 67(12):1755-7.
32. Hsueh YY#, Chang YJ, Huang TC, Fan SC, Wang DH, Chen JJ, Wu CC, Lin SC. Functional recoveries of sciatic nerve regeneration by combining chitosan coated conduit and neurosphere cells induced from adipose-derived stem cells. Biomaterials. 2014 Feb; 35(7):2234-44.
33. Chen WC, Hsueh YY *. Primary dermal melanoma in a 19-year-old asian man. Dermatol Surg. 2013 Apr; 39(4):662-5.
34. Hsueh YY#, Chiang YL, Wu CC, Lin SC. Spheroid formation and neural induction in human adipose-dervived stem cells on a chitosan-coated surface. Cells Tissues Organs,2012; 196(2):117-128.
35. Hsueh YY#, Chen CL, Pan SC. Analysis of factors influencing limb amputation in high-voltage electrically injured patients. Burns. 2011; 37(4):673-677.
36. Hsueh YY#, Shieh SJ, Chiu HY. Revascularization and dynamic distraction for a complex finger injury. J Hand Surg Eur Vol. 2010 Nov; 35(9):762-4.
37. Lee JW, Hsueh YY, Lee JS. Composite skull and dura defect reconstruction using combined latissimus dorsi musculocutaneous and serratus anterior muscle-rib free flap coupled with vascularized galea transfer:  a case report. Microsurgery. 2010 Nov; 30(8):632-5.
38. Hsueh YY#, Shieh SJ. Two-stage retroauricular flap to reconstruct a helical rim defect. Dermatol Surg. 2009 Nov; 35(11):1827-30.

Laboratory View

Laboratory activities